Skip to main content
Log in

In Vitro Activity of Organochalcogen Compounds: III. Cytotoxic Effect of 4-(2-Hydroxyaryl)-1,2,3-thiadiazoles Against K562 and Hela Tumor Cell Lines

  • Published:
Russian Journal of General Chemistry Aims and scope Submit manuscript

Abstract

In vitro antitumor activity of some 4-(2-hydroxyaryl)-1,2,3-thidiazoles was studied against erythroleukemia (K562) and cervical carcinoma (HeLa) cell lines.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Scheme
Scheme
Fig. 1.

Similar content being viewed by others

REFERENCES

  1. Popova, E.A., A.A. Kornev, Shmakov, S.V., Nepochatyi, G.D., Kotyunina, O.A., Petrov, M.L., Boitsov, V.M., and Stepakov, A.V., Russ. J. Gen. Chem., 2020, vol. 90, no. 11, p. 2214. https://doi.org/10.1134/S107036322011033X

    Article  CAS  Google Scholar 

  2. Zhan, P., Liu, X.Y., Li, Z.Y., Fang, Z.J., Li, Z., Wang, D.F., Pannecouque, C., and Clercq, E.D., Bioorg. Med. Chem., 2009, vol. 17, no. 16, p. 5920. https://doi.org/10.1016/j.bmc.2009.07.004

    Article  CAS  PubMed  Google Scholar 

  3. Wu, M.J., Sun, Q.M., Yang, C.H., Chen, D.D., Ding, J., Chen, Y., Lin, L.P., and Xie, Y.Y., Bioorg. Med. Chem. Lett., 2007, vol. 17, no. 4, p. 869. https://doi.org/10.1016/j.bmcl.2006.11.060

    Article  CAS  PubMed  Google Scholar 

  4. Wang, T.T., Bing, G.F., Zhang, X., Qin, Z.F., Yu, H.B., Qin, X., Dai, H., and Fang, J.X., ARKIVOC, 2010, p. 330. https://doi.org/10.3998/ark.5550190.0011.228

  5. Wang, Z.H., Guo, Y.Z., Zhang, J., Ma, L., Song, H.B., and Fan, Z.J., J. Agric. Food. Chem., 2010, vol. 58, no. 5, p. 2715. https://doi.org/10.1021/jf902168d

    Article  CAS  PubMed  Google Scholar 

  6. Wang, H., Yang, Z.K., Fan, Z.J., Wu, Q.J., Zhang, Y.J., Mi, N., Wang, S.X., Zhang, Z.C., Song, H.B., and Liu, F., J. Agric. Food. Chem., 2011, vol. 59, no. 2, p. 628. https://doi.org/10.1021/jf104004q

    Article  CAS  PubMed  Google Scholar 

  7. Dong, W.-L., Liu, Z.-X., Liu, X.-H., Li, Z.-M., and Zhao, W.-G., Eur. J. Med. Chem., 2010, vol. 45, no. 5, p. 1919. https://doi.org/10.1016/j.ejmech.2010.01.032

    Article  CAS  PubMed  Google Scholar 

  8. Pannecouque, C., Szafarowicz, B., Volkova, N., Bakulev, V., Dehaen, W., Mély, Y., and Daelemans, D., Antimicrob. Agents. Chemother., 2010, vol. 54, no. 4, p. 1461. https://doi.org/10.1128/AAC.01671-09

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Petrov, M.L., Yekhlef, M., Teplyakov, F.S., and Androsov, D.A., Russ. J. Org. Chem., 2012, vol. 48, no. 5, p. 728. https://doi.org/10.1134/S1070428012050168

    Article  CAS  Google Scholar 

  10. Petrov, M.L., Dehaen, W., Abramov, M.A., Abramova, I.P., Androsov, D.A., Russ. J. Org. Chem., 2002, vol. 38, no. 10, p. 1510. https://doi.org/10.1023/A:1022568808446

    Article  CAS  Google Scholar 

  11. Shafran, Y., Glukhareva, T., Dehaen, W., and Bakulev, V., Adv. Heterocycl. Chem., 2018, vol. 126, p. 109. https://doi.org/10.1016/bs.aihch.2017.12.001

    Article  CAS  Google Scholar 

  12. Tests were performed according to manufacturer protocol https://www.gbiosciences.com/Bioassays/Alamar-Blue-Cell-Viability-Assay

Download references

Funding

This work is supported by the Russian Science Foundation under grant 20-15-00332.

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to E. A. Popova or V. M. Boitsov.

Ethics declarations

No conflict of interest was declared by the authors.

Additional information

For communication II, see [1].

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Popova, E.A., Kornev, A.A., Bessonov, V.V. et al. In Vitro Activity of Organochalcogen Compounds: III. Cytotoxic Effect of 4-(2-Hydroxyaryl)-1,2,3-thiadiazoles Against K562 and Hela Tumor Cell Lines. Russ J Gen Chem 90, 2400–2404 (2020). https://doi.org/10.1134/S1070363220120270

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1070363220120270

Keywords:

Navigation