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Effetti metabolici della chirurgia bariatrica

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L'Endocrinologo Aims and scope

Sommario

La chirurgia bariatrica, nata come terapia “estrema” dell’obesità, ha mostrato, in un continuo crescendo di evidenze scientifiche, uno spettro di effetti benefici duraturi su tutte le componenti della sindrome metabolica, attraverso meccanismi d’azione, almeno in parte indipendenti dagli esiti ponderali, e ad oggi non ancora interamente noti, guadagnando così la dizione di “chirurgia metabolica” (Fig. 1) (Rubino et al. in Ann. Surg. 259(1):117–122, 2014). Su tale base appare, pertanto, evidente la necessità di inserire appropriatamente tale strumento terapeutico nell’ambito di percorsi non solo mirati agli esiti “bariatrici”, ma nell’ambito più esteso dei dismetabolismi della sindrome metabolica.

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Fig. 1
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Bibliografia

  1. Rubino F, Shukla A, Pomp A et al. (2014) Bariatric, metabolic, and diabetes surgery: what’s in a name? Ann Surg 259(1):117–122

    Article  PubMed  Google Scholar 

  2. Buchwald H, Avidor Y, Braunwald E et al. (2004) Bariatric surgery: a systematic review and meta-analysis. JAMA 292:1724–1737

    Article  CAS  PubMed  Google Scholar 

  3. Fried M, Yumuk V, Oppert JM et al. (2014) Interdisciplinary European guidelines on metabolic and bariatric surgery. Obes Surg 24:42–55

    Article  CAS  PubMed  Google Scholar 

  4. Sjöström L, Narbro K, Sjöström CD et al. (2007) Swedish Obese Subjects study: effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 357:741–752

    Article  PubMed  Google Scholar 

  5. Westerveld D, Yang D (2016) Through thick and thin: identifying barriers to bariatric surgery, weight loss maintenance, and tailoring obesity treatment for the future. Surg Res Pract 2016:8616581

    PubMed  PubMed Central  Google Scholar 

  6. Rubino F, Nathan DM, Eckel RH et al. (2016) Metabolic surgery in the treatment algorithm for type 2 diabetes: a joint statement by international diabetes organizations. Surg Obes Relat Dis 12(6):1144–1162

    Article  PubMed  Google Scholar 

  7. Borisienko O, Adam D, Funch-Jensen P et al. (2015) Bariatric surgery can lead to net cost savings to health care systems: results from a comprehensive European decision analytic model. Obes Surg 25(9):1559–1568

    Article  Google Scholar 

  8. Sarzani R, Bordicchia M, Spannella F et al. (2014) Hypertensive heart disease and obesity: a complex interaction between hemodynamic and not hemodynamic factors. High Blood Press Cardiovasc Prev 21(2):81–87

    Article  CAS  PubMed  Google Scholar 

  9. Sjöström L (2013) Review of the key results from the Swedish Obese Subjects (SOS) trial—a prospective controlled intervention study of bariatric surgery. J Intern Med 273(3):219–234

    Article  PubMed  Google Scholar 

  10. Sarzynski MA, Jacobson P, Rankinen T et al. (2011) Association of GWAS-based candidate genes with HDL-cholesterol levels before and after bariatric surgery in the Swedish obese subjects study. J Clin Endocrinol Metab 96(6):E953–E957

    Article  CAS  PubMed  Google Scholar 

  11. Zlabek JA, Grimm MS, Larson CJ et al. (2005) The effect of laparoscopic gastric bypass surgery on dyslipidemia in severely obese patients. Surg Obes Relat Dis 1(6):537–542

    Article  PubMed  Google Scholar 

  12. Savastano S, Di Somma C, Pizza G et al. (2011) Liver-spleen axis, insulin-like growth factor-(IGF)-I axis and fat mass in overweight/obese females. J Transl Med 9:136

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Burza MA, Romeo S, Kotronen A et al. (2013) Long-term effect of bariatric surgery on liver enzymes in the Swedish Obese Subjects (SOS) study. PLoS ONE 8(3):e60495

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Neuman MG, Nanau RM, Cohen LB (2015) Nonmedicinal interventions in nonalcoholic fatty liver disease. Can J Gastroenterol Hepatol 29(5):241–252

    Article  PubMed  PubMed Central  Google Scholar 

  15. Malin SK, Kashyap SR (2016) Effects of various gastrointestinal procedures on b-cell function in obesity and type 2 diabetes. Surg Obes Relat Dis 12(6):1213–1219

    Article  PubMed  Google Scholar 

  16. Laferrère B, Teixera J, MCGinty J et al. (2008) Effect of weight loss by gastric bypass surgery versus hypocaloric diet on glucose and incretin levels in patients with type 2 diabetes. J Clin Endocrinol Metab 93(7):2479–2485

    Article  PubMed  PubMed Central  Google Scholar 

  17. Tilg H, Kaser A (2011) Gut microbiome, obesity, and metabolic dysfunction. J Clin Invest 121(6):2126–2132

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Malin SK, Samat A, Wolski K et al. (2013) Improved acylated ghrelin suppression at 2 years in obese patients with type 2 diabetes: effects of bariatric surgery vs standard medical therapy. Int J Obes 38(3):364–370

    Article  Google Scholar 

  19. Buchwald H, Estok R, Fahrbach K et al. (2009) Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med 122(3):248–256

    Article  PubMed  Google Scholar 

  20. Buse JB, Caprio S, Cefalu WT et al. (2009) How do we define cure of diabetes? Diabetes Care 32(11):2133–2135

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Unità di Endocrinologia, Dipartimento Medicina Clinica e Chirurgica, Università degli Studi di Napoli Federico II, Napoli, Italia

    Silvia Savastano

  2. I.O.S. & Coleman Srl, Acerra, Napoli, Italia

    Luigi Barrea

  3. Dipartimento di Scienze Mediche, Università degli Studi di Torino, Torino, Italia

    Sara Belcastro & Fabio Broglio

Authors
  1. Silvia Savastano
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  2. Luigi Barrea
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  3. Sara Belcastro
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  4. Fabio Broglio
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Corresponding authors

Correspondence to Silvia Savastano or Fabio Broglio.

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Conflitto di interesse

Gli autori Silvia Savastano, Luigi Barrea, Sara Belcastro e Fabio Broglio dichiarano di non avere conflitti di interesse.

Consenso informato

Lo studio presentato in questo articolo non ha richiesto sperimentazione umana.

Studi sugli animali

Gli autori di questo articolo non hanno eseguito studi sugli animali.

Additional information

Proposto da Raffaella Arvat.

Materiale elettronico supplementare

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Savastano, S., Barrea, L., Belcastro, S. et al. Effetti metabolici della chirurgia bariatrica. L'Endocrinologo 18, 214–218 (2017). https://doi.org/10.1007/s40619-017-0349-4

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  • DOI: https://doi.org/10.1007/s40619-017-0349-4

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