Drugs & Therapy Perspectives

, Volume 34, Issue 5, pp 207–211 | Cite as

Base the short-term use of ibuprofen in infants aged 3–6 months on body weight and administer via the oral route if possible

  • Adis Medical WritersEmail author
Disease Management


Ibuprofen is the NSAID most commonly used to treat mild-moderate pain, fever and inflammation in children, although dosage recommendations in infants aged 3–6 months still differ between countries. Based on the available evidence, the short-term use of ibuprofen to manage pain and fever appears to be effective and safe in infants aged 3–6 months who weigh ≥ 5–6 kg. The dosage should be weight-based, with preference given to oral preparations. To minimize the risk of renal toxicity, it is important to ensure than the infant is adequately hydrated.


Compliance with ethical standards

Conflict of interest

The article was adapted from Pediatric Drugs 2017;19(4):277–20 [2] by employees of Adis/Springer, who are responsible for the article content and declare no conflicts of interest.


The preparation of this review was not supported by any external funding.


  1. 1.
    de Martino M, Chiarugi A, Boner A, et al. Working towards an appropriate use of ibuprofen in children: an evidence-based appraisal. Drugs. 2017;77(12):1295–311.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Ziesenitz VC, Zutter A, Erb TO, et al. Efficacy and safety of ibuprofen in infants aged between 3 and 6 months. Paediatr Drugs. 2017;19(4):277–90.CrossRefPubMedGoogle Scholar
  3. 3.
    Adis Medical Writers. Consider pharmacological treatment to close patent ductus arteriosus in preterm infants when the condition is haematologically significant. Drugs Ther Perspect. 2017;33(1):22–5.CrossRefGoogle Scholar
  4. 4.
    Kauffman RE, Nelson MV. Effect of age on ibuprofen pharmacokinetics and antipyretic response. J Pediatr. 1992;121(6):969–73.CrossRefPubMedGoogle Scholar
  5. 5.
    Kyllonen M, Olkkola KT, Seppala T, et al. Perioperative pharmacokinetics of ibuprofen enantiomers after rectal administration. Paediatr Anaesth. 2005;15(7):566–73.CrossRefPubMedGoogle Scholar
  6. 6.
    Vilenchik R, Berkovitch M, Jossifoff A, et al. Oral versus rectal ibuprofen in healthy volunteers. J Popul Ther Clin. 2012;19(2):e179–86.Google Scholar
  7. 7.
    Brown RD, Wilson JT, Kearns GL, et al. Single-dose pharmacokinetics of ibuprofen and acetaminophen in febrile children. J Clin Pharmacol. 1992;32(3):231–41.CrossRefPubMedGoogle Scholar
  8. 8.
    Simila S, Kouvalainen K, Keinanen S. Oral antipyretic therapy. Scand J Rheumatol. 1976;5(2):81–3.CrossRefPubMedGoogle Scholar
  9. 9.
    Wilson G, Guerra AJ, Santos NT. Comparative study of the antipyretic effect of ibuprofen (oral suspension) and paracetamol (suppositories) in paediatrics. J Int Med Res. 1984;12(4):250–4.CrossRefPubMedGoogle Scholar
  10. 10.
    Yue Z, Jiang P, Sun H, et al. Association between an excess risk of acute kidney injury and concomitant use of ibuprofen and acetaminophen in children, retrospective analysis of a spontaneous reporting system. Eur J Clin Pharmacol. 2014;70(4):479–82.CrossRefPubMedGoogle Scholar
  11. 11.
    Lesko SM, Mitchell AA. The safety of acetaminophen and ibuprofen among children younger than two years old. Pediatrics. 1999;104(4):e39.CrossRefPubMedGoogle Scholar
  12. 12.
    Ashraf E, Ford L, Geetha R, Cooper S. Safety profile of ibuprofen suspension in young children. Inflammopharmacology. 1999;7(3):219–25.CrossRefPubMedGoogle Scholar
  13. 13.
    Joshi YM, Sovani VB, Joshi VV, et al. Comparative evaluation of the antipyretic efficacy of ibuprofen and paracetamol. Indian Pediatr. 1990;27(8):803–6.PubMedGoogle Scholar
  14. 14.
    Romsing J, Walther-Larsen S. Peri-operative use of nonsteroidal anti-inflammatory drugs in children: analgesic efficacy and bleeding. Anaesthesia. 1997;52(7):673–83.CrossRefPubMedGoogle Scholar
  15. 15.
    Maunuksela EL, Ryhanen P, Janhunen L. Efficacy of rectal ibuprofen in controlling postoperative pain in children. Can J Anaesth. 1992;39(3):226–30.CrossRefPubMedGoogle Scholar
  16. 16.
    Kokki H, Hendolin H, Maunuksela EL, et al. Ibuprofen in the treatment of postoperative pain in small children: a randomized double-blind-placebo controlled parallel group study. Acta Anaesthesiol Scand. 1994;38(5):467–72.CrossRefPubMedGoogle Scholar
  17. 17.
    Pfaff JA, Hsu K, Chennupati SK. The use of ibuprofen in posttonsillectomy analgesia and its effect on posttonsillectomy hemorrhage rate. Otolaryngol Head Neck Surg. 2016;155(3):508–13.CrossRefPubMedGoogle Scholar
  18. 18.
    Summary review for regulatory action. Caldolor injection/ibuprofen intravenous injection (NDA 22348, Supplement 005). Silver Spring: US Food and Drug Administration; 2015.Google Scholar
  19. 19.
    Clark E, Plint AC, Correll R, et al. A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. Pediatrics. 2007;119(3):460–7.CrossRefPubMedGoogle Scholar
  20. 20.
    Lesko SM, Mitchell AA. An assessment of the safety of pediatric ibuprofen: a practitioner-based randomized clinical trial. JAMA. 1995;273(12):929–33.CrossRefPubMedGoogle Scholar
  21. 21.
    Hadas D, Youngster I, Cohen A, et al. Premarketing surveillance of ibuprofen suppositories in febrile children. Clin Pediatr. 2011;50(3):196–9.CrossRefGoogle Scholar
  22. 22.
    Balestracci A, Ezquer M, Elmo ME, et al. Ibuprofen-associated acute kidney injury in dehydrated children with acute gastroenteritis. Pediatr Nephrol. 2015;30:1873–8.CrossRefPubMedGoogle Scholar

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.SpringerAucklandNew Zealand

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