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Infection

, Volume 45, Issue 2, pp 221–225 | Cite as

Nosocomial transmission of carbapenem-resistant Klebsiella pneumoniae elucidated by single-nucleotide variation analysis: a case investigation

  • Hideharu Hagiya
  • Kotaro Aoki
  • Yukihiro Akeda
  • Noriko Sakamoto
  • Norihisa Yamamoto
  • Hisao Yoshida
  • Isao Nishi
  • Yoshikazu Ishii
  • Kazunori Tomono
Brief Report

Abstract

Identifying transmission route of antimicrobial-resistant pathogen is essential for appropriate infection control strategy in healthcare facilities. We report the utility of single-nucleotide variation analysis in tracing nosocomial transmission of antimicrobial-resistant pathogens by describing a pseudo-outbreak case of carbapenem-resistant Klebsiella pneumoniae. The present case highlights that infection control strategy should encompass pathological dissection rooms, neglected but potentially highly contaminated places in hospitals.

Keywords

Autopsy Carbapenem-resistant Enterobacteriaceae Nosocomial infection Pathological dissection room Whole-genome sequencing 

Notes

Compliance with ethical standards

Conflict of interest

All authors report no conflicts of interest relevant to this article.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Hideharu Hagiya
    • 1
    • 2
    • 3
  • Kotaro Aoki
    • 4
  • Yukihiro Akeda
    • 1
    • 2
    • 3
  • Noriko Sakamoto
    • 2
  • Norihisa Yamamoto
    • 1
    • 2
    • 3
  • Hisao Yoshida
    • 1
    • 2
    • 3
  • Isao Nishi
    • 5
  • Yoshikazu Ishii
    • 4
  • Kazunori Tomono
    • 1
    • 3
  1. 1.Department of Infection Control and PreventionOsaka University Graduate School of MedicineOsakaJapan
  2. 2.Research Institute for Microbial DiseasesOsaka UniversityOsakaJapan
  3. 3.Division of Infection Control and PreventionOsaka University HospitalSuitaJapan
  4. 4.Department of Microbiology and Infectious Diseases, Faculty of MedicineToho University School of MedicineTokyoJapan
  5. 5.Laboratory for Clinical InvestigationOsaka University HospitalSuitaJapan

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