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The role of cardamom on the hazardous effects of depleted uranium in cerebellum and midbrain of albino rats

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Abstract

The present study aimed to investigate uranium hazardous effects, as well as the ameliorative effects of cardamom on the cerebellum and midbrain of adult male albino rats at different time intervals. The administration of 40 mg/Kg of uranyl acetate dehydrate (UAD) caused a significant decrease in Pi, K+ ions contents and GSH level while, a significant increase in Na+ and Ca2+ ions content and MDA level were observed, which may be due to the decrease in ATP synthesis and the inhibition of Na+/K+ ATPase activity. Also, UDA has the ability to increase lipid peroxidation and decrease GSH synthesis. On the other hand, the administration of 250 mg/kg of cardamom extract induced significant increase in Pi, K+ ions content and GSH level, while it caused a significant decrease in Na+, Ca2+ ions content and MDA level which may be due to the increase of ATP synthesis and its anticonvulsant and antioxidant effects. It could be concluded that the pre -and post-treatment with cardamom could ameliorate the hazardous effects of UAD intoxication.

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Authors and Affiliations

  1. Zoology department, Helwan University, Cairo, Egypt

    Mona Abdel-Rahman

  2. Isotopes Geology department, Nuclear Materials Authority, Cairo, Egypt

    Mohamed Mahmoud Rezk

  3. Radioactive isotopes department, Atomic Energy Authority, Cairo, Egypt

    Seham Abdel Kader

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  1. Mona Abdel-Rahman
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  3. Seham Abdel Kader
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Abdel-Rahman, M., Rezk, M.M. & Kader, S.A. The role of cardamom on the hazardous effects of depleted uranium in cerebellum and midbrain of albino rats. Toxicol. Environ. Health Sci. 9, 64–73 (2017). https://doi.org/10.1007/s13530-017-0305-5

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