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Report of the Committee of the Japan Diabetes Society on the Research of Fulminant and Acute-onset Type 1 Diabetes Mellitus: New Diagnostic Criteria of Fulminant Type 1 Diabetes Mellitus (2012)

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Abstract

We have revised a part of the diagnostic criteria for fulminant type 1 diabetes. The new criteria were set both to express the essence of this disease of rapid increase of patients’ blood glucose and to be highly sensitive to reduce the misdiagnosis. After analyzing the data of 382 patients with newly-diagnosed fulminant type 1 diabetes, we adopted the HbA1c level of 8.7 % (NGSP value). The new criterion indicates 100 % of sensitivity and best value by ROC (receiver operation curve) analysis. In addition, we added a comment that “This value (HbA1c < 8.7 % in NGSP) is not applicable for patients with previously diagnosed glucose intolerance” on the new criteria and also a comment that “Association with HLA DRB1*04:05-DQB1*04:01 is reported” as a related finding. We did not revise the screening criteria and the other part of the diagnostic criteria, because they are still reliable.

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Acknowledgments

The authors appreciate Drs. M. Ohkubo (Toranomon Hospital), Y. Kajio and K. Yasuda (National Center for Global Health and Medicine), H. Kamoi (Nagaoka Red Cross Hospital), J. Satoh (Iwate Medical University), S. Tanaka (University of Yamanashi School of Medicine), K. Nakanishi (Okinaka Memorial Institute for Medical Research), S. Fujii (Ishikawa Prefectural Central Hospital), J. Miura (Tokyo Women’s Medical University School of Medicine) and S. Murao (KKR Takamatsu Hospital), for giving us important suggestions as collaborators in the subcommittee on Fulminant and Acute Type 1 diabetes, Committee on Type 1 diabetes, Japan Diabetes Society. We also thank Drs. T. Hirata (Kyoto University), C. Tsutsumi (Osaka Medical College), H. Takaike (Tokyo Women’s Medical University School of Medicine), M. Koga (Kinki Central Hospital) and K. Nakamura (Nagasaki University) to took part in the committee’s studies, and Ms. S. Mitsui and Ms. S. Ikeda (Osaka Medical College) for their excellent secretarial assistance.

Conflict of interest

The authors declare no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Japan

    Akihisa Imagawa

  2. Department of Internal Medicine (I), Osaka Medical College, Takatsuki, Japan

    Toshiaki Hanafusa

  3. Department of Endocrinology and Diabetes, Saitama Medical University, Saitama, Japan

    Takuya Awata

  4. Department of Endocrinology, Metabolism and Diabetes, Kinki University School of Medicine, Osaka, Japan

    Hiroshi Ikegami & Yumiko Kawabata

  5. Diabetes Center, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan

    Yasuko Uchigata

  6. Department of Laboratory Medicine, Ehime University School of Medicine, Ehime, Japan

    Haruhiko Osawa

  7. Department of Metabolism/Diabetes and Clinical Nutrition, Nagasaki University Hospital, Nagasaki, Japan

    Eiji Kawasaki

  8. Third Department of Internal Medicine, University of Yamanashi School of Medicine, Yamanashi, Japan

    Tetsuro Kobayashi

  9. Department of Internal Medicine, Saiseikai Central Hospital, Tokyo, Japan

    Akira Shimada

  10. Department of Internal Medicine, The Sakakibara Heart Institute of Okayama, Okayama, Japan

    Ikki Shimizu

  11. Department of Diabetes and Metabolism, Iwate Medical University, Morioka, Japan

    Kazuma Takahashi

  12. Department of Internal Medicine, Kakogawa Municipal Hospital, Kakogawa, Japan

    Masao Nagata

  13. Diabetes Center, Shiraishi Hospital, Ehime, Japan

    Hideichi Makino

  14. Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama, Japan

    Taro Maruyama

Authors
  1. Akihisa Imagawa
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  2. Toshiaki Hanafusa
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  3. Takuya Awata
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  4. Hiroshi Ikegami
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  5. Yasuko Uchigata
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  6. Haruhiko Osawa
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  7. Eiji Kawasaki
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  8. Yumiko Kawabata
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  9. Tetsuro Kobayashi
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  10. Akira Shimada
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  11. Ikki Shimizu
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  12. Kazuma Takahashi
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  13. Masao Nagata
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  14. Hideichi Makino
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  15. Taro Maruyama
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Corresponding author

Correspondence to Toshiaki Hanafusa.

Additional information

Toshiaki Hanafusa of Chairman, Akihisa Imagawa of Secretariat.

In 2012, the Japan Diabetes Society established the Committee of the Japan Diabetes Society on the Research of Fulminant and Acute-onset Type 1 Diabetes Mellitus, which published a committee report in J Jpn Diabetes Soc 2012; 55 (in Japanese) [1]. This is the English version of that report.

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Imagawa, A., Hanafusa, T., Awata, T. et al. Report of the Committee of the Japan Diabetes Society on the Research of Fulminant and Acute-onset Type 1 Diabetes Mellitus: New Diagnostic Criteria of Fulminant Type 1 Diabetes Mellitus (2012). Diabetol Int 3, 179–183 (2012). https://doi.org/10.1007/s13340-012-0098-3

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  • DOI: https://doi.org/10.1007/s13340-012-0098-3

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