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Perinatal Outcome After Intrauterine Transfusion in Rh Isoimmunized Mothers

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Abstract

Objective

The objective of the study was to assess the fetal outcome after receiving intrauterine transfusion (IUT) in Rh-isoimmunized pregnancy in a tertiary care center.

Study Design

This was a retrospective observational descriptive study in which all Rh-negative gravidas with isoimmunization warranting IUTs (40 patients) were analyzed during the period from January 1, 2010 to October 31, 2015. Primary outcome variables were fetal outcomes and procedural-related factors.

Results

Forty pregnancies (13—hydropic, 27—non-hydropic) required 74 IUTs. IUT was performed at gestational age of 15.4–33 weeks when indicated. The amount of blood transfused ranged from 4 to 110 ml. There were two sudden intrauterine fetal deaths during the procedure, four post-procedure intrauterine fetal deaths in fetuses with severe hydrops, and three neonatal deaths. The overall survival rate was found to be 77.5%.

Conclusion

IUT was found to be an effective therapy in correcting anemia in fetuses of Rh isoimmunized mothers. Early diagnosis of fetal anemia and intrauterine blood transfusion by an experienced fetal medicine specialist is very important for the perinatal outcome.

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Fig. 1

Source: Modified from Mari et al. [9]. Reproduced with permission

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Seth GS Medical College, Nowrosjee Wadia Maternity Hospital, Parel, Mumbai, 400012, India

    Omkar Potdar, Hemraj R. Narkhede & Purnima R. Satoskar

  2. Mumbai, India

    Hemraj R. Narkhede

Authors
  1. Omkar Potdar
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  2. Hemraj R. Narkhede
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  3. Purnima R. Satoskar
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Contributions

PRS designed the study model, performed IUT, and reviewed the article; HRN assisted in the IUT, wrote the article, and helped in compilation and analysis of data; and OP assisted in the IUT, compiled and analyzed the data, and helped in article write-up.

Corresponding author

Correspondence to Hemraj R. Narkhede.

Ethics declarations

Conflict of interest

The authors have no conflicts of interest.

Ethical Approval

For this type of study, formal consent is not required and waiver consent was obtained.

Human and Animal Rights

Retrospective observation study analyzes records of Rh-sensitized women in pregnancy.

Informed Consent

Waiver consent was taken.

Additional information

Dr. Omkar Potdar MD is a Registrar in the Department of Obstetrics and Gynecology, Seth G S Medical College, Nowrosjee Wadia Maternity Hospital, Parel, Mumbai, 400012, India; Dr. Hemraj R Narkhede MD is a Assistant Professor in the Department of Obstetrics and Gynecology, Seth G S Medical College, Nowrosjee Wadia Maternity Hospital, Parel, Mumbai, 400012, India; Dr. Purnima R. Satoskar MD, DNB, FRCOG is a Professor in the Department of Obstetrics and Gynecology, Seth G S Medical College, Nowrosjee Wadia Maternity Hospital, Parel, Mumbai, 400012, India.

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Potdar, O., Narkhede, H.R. & Satoskar, P.R. Perinatal Outcome After Intrauterine Transfusion in Rh Isoimmunized Mothers. J Obstet Gynecol India 69, 123–128 (2019). https://doi.org/10.1007/s13224-018-1108-6

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  • DOI: https://doi.org/10.1007/s13224-018-1108-6

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