Journal of Food Science and Technology

, Volume 55, Issue 5, pp 1880–1888 | Cite as

Antiglycation and antioxidant activities of mogroside extract from Siraitia grosvenorii (Swingle) fruits

  • Hesheng Liu
  • Chengcheng Wang
  • Xiangyang Qi
  • Jian Zou
  • Zhida Sun
Original Article


Siraitia grosvenorii (Swingle) is one kind of medical and edible plants with various health-promoting properties. Recently, its hypoglycemic and antidiabetic activities have been reported, but the underlying mechanism remains to be explored. The current study was aimed to investigate the antioxidant and antiglycation activities of mogroside extract (MGE) from Siraitia grosvenorii (Swingle). The results showed that compared to glycated BSA, MGE at middle (125 μg/mL) and high dose (500 μg/mL) significantly inhibited BSA glycation evidenced by decreased fluorescent AGEs formation, protein carbonyls and Nε-(carboxymethyl) lysine (CML) level at 500 μg/mL by 58.5, 26.7 and 71.2%, respectively. Additionally, the antiglycative activity of MGE (500 μg/mL) was comparable to aminoguanidine (AG) at the equal concentration. However, the inhibitory effect of MGE on glycation-induced increase of fructosamine level and decrease of thiol level was not remarkable. MGE was a potent peroxide radicals scavenger (851.8 μmol TE/g), moderate DPPH and ABTS radicals scavenger with IC50 1118.1 and 1473.2 μg/mL, respectively, corresponding to positive controls ascorbic acid of IC50 9.6 μg/mL, and trolox of IC50 47.9 μg/mL, respectively, and mild reducing power. These findings suggest that MGE may serve as a new promising antiglycative agent against diabetic complications by inhibiting protein glycation and glycoxidation.


Siraitia grosvenorii (Swingle) Cucurbitane triterpene glycosides Antiglycation Antioxidant 







2,2′-Azobis (2-amidinopropane) dihydrochloride


2,2′-Azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)




Advanced glycation end products


Analysis of variance


Area under curve


Bovine serum albumin








4,5-Dimethyl-3-phenacylthiazolium chloride


5,5′-Dithiobis-(2-nitrobenzoic acid)


Enzyme-linked immunosorbent assay


Fluorescence intensity




Generally recognized as safe


Mogroside extract




4-Nitro blue tetrazolium


Oxygen radical absorbance capacity


Phosphate buffered saline


Reactive oxygen species


Standard deviation


Trichloroacetic acid


6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid



The authors thank Guilin Layn Natural Ingredients Corp. for generously providing MGE. This work was funded by National Natural Science Foundation of China (No. 31171780), Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (No. 20171033) and general program from Department of Education of Zhejiang Province, China (Y201738544).

Compliance with ethical standards

Conflict of interest

The authors declare that there are no competing interests.

Supplementary material

13197_2018_3105_MOESM1_ESM.docx (142 kb)
Supplementary material 1 (DOCX 143 kb)


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Copyright information

© Association of Food Scientists & Technologists (India) 2018

Authors and Affiliations

  • Hesheng Liu
    • 1
    • 3
  • Chengcheng Wang
    • 2
  • Xiangyang Qi
    • 3
    • 4
  • Jian Zou
    • 3
  • Zhida Sun
    • 1
  1. 1.College of Food Science and TechnologyHuazhong Agricultural UniversityWuhanPeople’s Republic of China
  2. 2.Shanghai OPM Biosciences Co., Ltd.ShanghaiPeople’s Republic of China
  3. 3.College of Biological and Environmental SciencesZhejiang Wanli UniversityNingboPeople’s Republic of China
  4. 4.Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business UniversityBeijingPeople’s Republic of China

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