Abstract
Antiphospholipid syndrome is an autoantibody mediated disorder characterised by thrombotic manifestations and/or obstetric morbidity. The autoantibodies are directed against phospholipid binding plasma proteins. Amongst the clinical features abdominal presentation is an unusual feature in this syndrome. We present the case report of a 32-year female whose complaints was abdominal pain for one week and no history of previous foetal loss, who responded well to warfarin and has not developed systemic lupus erythematous even after follow up. Characteristic of this patient is the appearance of auto antibodies against Golgi bodies. Although antinuclear antibodies are seen in patients of rheumatic disease like systemic lupus erythematous, its presence in individuals with unusual presentation of antiphospholipid syndrome may facilitate in diagnosis.
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Vianna JL, Khamashta MA, Ordi-Ros J, Font J, Cervers R, Lopez-Soto A, et al. Comparison of the primary and secondary antiphospholipid syndrome: a European Multicenter Study of 114 patients. Am J Med. 1994;96(1):3–9.
Emmi G, Silvestri E, Squatrito D, Cluccciarelli L, Cameli AM, Denas G, et al. Approach to differential diagnosis of antiphospholipid antibody syndrome and related conditions. Sci World J. 2014;214:1–8. https://doi.org/10.1155/2014/341342.
Rossi A, Colorio C, Puente D, Forastiero R. An update on current management strategies for antiphospholipid syndrome-related thrombosis. Clin Lipidol. 2014;9(1):91–100.
Turiel M, Sarzi-Puttini P, Peretti R, Rossi E, Atzeni F, Parsons W, et al. Thrombotic risk factors in primary antiphospholipid syndrome: a 5-year prospective study. Stroke. 2005;36(7):1490–4. https://doi.org/10.1161/01.str.0000170645.40562.09.
de Carvalho JF, Caleiro MTC, Vendramini M, Bonfa E. Clinical and laboratory evaluation of patients with antiphospholipid syndrome according to the frequency of antinuclear antibodies (ANA Hep-2). Bras J Rheumatol. 2010;50(3):262–72.
Blanco Y, Ramos-Casals M, García-Carrasco M, Cervera R, Font J, Ingelmo M. Primary antiphospholipid syndrome evolving into systemic lupus erythematosus: a report of 3 new cases and a review of the literature. Rev Clin Esp. 1999;199:586–8.
Carbone J, Orera M, Rodríguez-Mahou M, Rodríguez-Pérez C, Sánchez-Ramón S, Seoane E, et al. Immunological abnormalities in primary APS evolving into SLE: 6 years follow-up in women with repeated pregnancy loss. Lupus. 1999;8:274–8.
Lopes MRU, Danowski A, Funke A, Rego J, Levy R, de Andrade DCO. Update on antiphospholipd antibody syndrome. Rev Assoc Med Bras. 2017;63(11):994–9.
Ohgi S, Ohgi N. Relation between isolated venous thrombi in soleal muscle and positive antinuclear antibody. Ann Vasc Dis. 2012;5(3):321–7. https://doi.org/10.3400/avd.oa.12.00052.
Hormerova J. Homocysteine and venous thromboembolism—is there any link? Cor et Vasa. 2013;55(3):e248–58. https://doi.org/10.1016/j.crvasa.2013.01.007.
de Carvalho JF, Caleiro MT, Bonfa E. Hyperhomocysteinemia and primary antiphospholiipd syndrome. Bras J Rheumatol. 2009;49(4):337–45.
Stojan G, Gu W, Petri M. Homocysteine, antiphospholipid antibodies and risk of vascular events in patients with SLE. Ann Rheum Dis. 2017;76:306.
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Verma, N.R., Patel, S., Nanda, R. et al. Primary Antiphospholipid Syndrome Associated with Autoantibodies Against Golgi Bodies: A Case Report of a 32-Year-Old Female. Ind J Clin Biochem 34, 363–366 (2019). https://doi.org/10.1007/s12291-018-0796-0
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DOI: https://doi.org/10.1007/s12291-018-0796-0