Association of Inflammatory and Liver Markers with Cardiometabolic Risk Factors in Patients with Depression

  • Naresh Nebhinani
  • Praveen Sharma
  • Vrinda Pareek
  • Navratan Suthar
  • Shobhan Jakhotia
  • Mukesh Gehlot
  • Purvi Purohit
Original Research Article

Abstract

Metabolic syndrome (MS) is found to be more prevalent in patients with psychiatric disorders including depression. This study aimed to assess the association of inflammatory and liver markers with cardiometabolic risk factors in patients with Depressive disorders. Prevalence of MS by using Modified NCEP ATP-III Criteria and liver enzymes and CRP were assessed in 382 patients with depressive disorders. MS prevalence was 27.7% and lower HDL level was the commonest metabolic abnormality. ALT, GGT, and CRP levels were positively correlated with weight and BMI. ALT, GGT, and CRP levels were significantly greater in patients with abnormal waist circumference, triglyceride levels and raised blood pressure, compared to patients with normal indices. Such association was not found with abnormal HDL cholesterol and hyperglycemia. Levels of GGT and CRP were significantly greater in patients with MS compared to patients without MS and CRP was significant predictor for MS. To conclude, one-fourth of depressed patients had MS. MS and metabolic abnormalities were associated with inflammatory marker and liver enzymes. Patients with depression should be regularly evaluated for cardiovascular risk factors, liver enzymes, and inflammatory markers.

Keywords

Metabolic syndrome Liver enzymes Inflammatory markers Depression India 

Notes

Compliance with Ethical Standards

Conflict of interest

The authors report no conflict of interest.

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Copyright information

© Association of Clinical Biochemists of India 2018

Authors and Affiliations

  • Naresh Nebhinani
    • 1
  • Praveen Sharma
    • 2
  • Vrinda Pareek
    • 1
  • Navratan Suthar
    • 1
  • Shobhan Jakhotia
    • 1
  • Mukesh Gehlot
    • 1
  • Purvi Purohit
    • 2
  1. 1.Department of PsychiatryAll India Institute of Medical ScienceJodhpurIndia
  2. 2.Department of BiochemistryAll India Institute of Medical ScienceJodhpurIndia

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