Study of the Effect of Bisphenol A on Oxidative Stress in Children with Autism Spectrum Disorders
The role of bisphenol A (BPA) in autism was investigated in 49 children (mean age = 5.950 ± 1.911 years) with autism spectrum disorders (ASDs) and 40 comparable age and sex matched children used as controls (mean age = 5.333 ± 2.279 years). In addition, 8-Hydroxydeoxyguanosine (8-oxodG) was also studied as a biomarker of oxidative stress in the same set of two selected groups. The results showed that both BPA and 8-oxodG were significantly higher in children with autism than those of control children (p values = 0.025 and 0.0001, respectively). There were positive correlations between both BPA and 8-oxodG with ASDs severity (r = 0.400 and 0.805, respectively), these correlations were highly significant (p values = 0.004 and 0.001, respectively). There was a significance positive correlation between BMI and BPA, but the correlation between BMI and 8-oxodG was not significant in children with autism. The observed results revealed that BPA may increase oxidative stress resulting in mitochondrial dysfunction that affecting the behavior and functioning of ASDs children.
KeywordsAutism Bisphenol A 8-Hydroxydeoxyguanosine Oxidative stress
We would like to thank all children participated in this study and their families.
- 4.Kardas F, Bayram AK, Demirci E, Akin L, Ozmen S, Kendirci M, et al. Increased serum phthalates (MEHP, DEHP) and bisphenol a concentrations in children with autism spectrum disorder: the role of endocrine disruptors in autism etiopathogenesis. J Child Neurol. 2016;31(5):629–35.CrossRefPubMedGoogle Scholar
- 8.Szychowski KA, W´ojtowicz AK. Components of plastic disrupt the function of the nervous system. Poste¸py Higieny iMedycyny Do´swiadczalnej. 2013; 67:499–506.Google Scholar
- 10.American Psychiatric Association (APA). Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington DC; 1994.Google Scholar
- 20.DSM-IV-TR. A. Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: American Psychiatric Association; 2000.Google Scholar
- 22.Tanner JM, Hiernaux J, Jarman S. Growth and physique studies. In: Weiner JS, Lourie JA, editors. Human biology: a guide to field methods, I.B.P. handbook No.9. Oxford and Edinburgh: Blackwell Scientific Publications; 1969. p. 1–29.Google Scholar
- 23.WHO| The WHO Child Growth Standards, 2007-2017. WHO.http://www.who.int/childgrowth/en/.
- 25.Rossignol DA, Frye RE. Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism. Front Physiol. 2014; 5(150):1–15.http://journal.frontiersin.org/article/10.3389/fphys.2014.00150/full Doi: 10.3389/fphys.2014.00150