Indian Journal of Clinical Biochemistry

, Volume 33, Issue 2, pp 196–201 | Cite as

Study of the Effect of Bisphenol A on Oxidative Stress in Children with Autism Spectrum Disorders

  • Fateheya M. Metwally
  • Hend Rashad
  • Hala M. Zeidan
  • Ayman Kilany
  • Ehab R. Abdol Raouf
Original Article


The role of bisphenol A (BPA) in autism was investigated in 49 children (mean age = 5.950 ± 1.911 years) with autism spectrum disorders (ASDs) and 40 comparable age and sex matched children used as controls (mean age = 5.333 ± 2.279 years). In addition, 8-Hydroxydeoxyguanosine (8-oxodG) was also studied as a biomarker of oxidative stress in the same set of two selected groups. The results showed that both BPA and 8-oxodG were significantly higher in children with autism than those of control children (p values = 0.025 and 0.0001, respectively). There were positive correlations between both BPA and 8-oxodG with ASDs severity (r = 0.400 and 0.805, respectively), these correlations were highly significant (p values = 0.004 and 0.001, respectively). There was a significance positive correlation between BMI and BPA, but the correlation between BMI and 8-oxodG was not significant in children with autism. The observed results revealed that BPA may increase oxidative stress resulting in mitochondrial dysfunction that affecting the behavior and functioning of ASDs children.


Autism Bisphenol A 8-Hydroxydeoxyguanosine Oxidative stress 



We would like to thank all children participated in this study and their families.


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Copyright information

© Association of Clinical Biochemists of India 2017

Authors and Affiliations

  • Fateheya M. Metwally
    • 1
  • Hend Rashad
    • 1
  • Hala M. Zeidan
    • 2
  • Ayman Kilany
    • 2
  • Ehab R. Abdol Raouf
    • 2
  1. 1.Environmental Research Division, Occupational and Environmental Medicine DepartmentNational Research CentreCairoEgypt
  2. 2.Medical Research Division, Research on Children with Special Needs DepartmentNational Research CentreCairoEgypt

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