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Clinical update on hypomethylating agents

  • Matthieu Duchmann
  • Raphael ItzyksonEmail author
Progress in Hematology Epigenetic abnormalities and therapies for hematological malignancies

Abstract

Hypomethylating agents (HMAs), azacitidine and decitabine, are standards of care in higher-risk myelodysplastic syndromes and in acute myeloid leukemia patients ineligible for intensive therapy. Over the last 10 years, research efforts have sought to better understand their mechanism of action, both at the molecular and cellular level. These efforts have yet to robustly identify biomarkers for these agents. The clinical activity of HMAs in myeloid neoplasms has been firmly established now but still remains of limited magnitude. Besides optimized use at different stages of the disease, most of the expected clinical progress with HMAs will come from the development of second-generation compounds orally available and/or with improved pharmacokinetics, and from the search, so far mostly empirical, of HMA-based synergistic drug combinations.

Keywords

Hypomethylating agents Myeloid malignancies Myelodysplastic syndromes Acute myeloid leukemia Chronic myelomonocytic leukemia 

Notes

Compliance with ethical standards

Conflict of interest

MD declares no competing financial interests. RI has received research funding from Janssen, Novartis and Oncoethix (now Merck), honoraria from Sanofi, BMS and Celgene and consulting fees from Novartis, Otsuka Pharma, Jazz Pharmaceuticals, Karyopharm, StemLine Therapeutics and Abbvie.

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Copyright information

© Japanese Society of Hematology 2019

Authors and Affiliations

  1. 1.INSERM/CNRS UMR 944/7212, Saint-Louis Research Institute, Paris Diderot UniversityParisFrance
  2. 2.Hematology Laboratory, Hôpital Saint-LouisAssistance Publique Hôpitaux de ParisParisFrance
  3. 3.Clinical Hematology Department, Hôpital Saint-LouisAssistance Publique Hôpitaux de ParisParisFrance

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