Depression and one carbon metabolic pathway: A study among a mendelian population from North India


Depression is multi-factorial in origin and results from intricate mechanisms with no single identifiable risk factor. The present study is a cross-sectional study, conducted among 808 participants aged 30–70 years from a single mendelian, largely vegetarian population from North India. Socio- demographic and depression status were assessed through standard interview schedule among recruited individuals. Chemi- luminescence Immunoassay technique by Immulite®1000 is used to analyse homocysteine, folate and vitamin B12 levels. Of the total studied subjects, 31.1% were found to be having depression with higher rate among females (35.7%) compared to males (24.6%) (p = 0.002). Hyperhomocysteinemia and folate deficiency were found to pose an increased risk for moderate/ severe depression, though not significant. Folate repletion was playing a compensatory role for vitamin B12 deficiency among depressed individuals. MTHFR C677T gene polymorphism was not associated with depression in the present study.

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The authors are thankful to Prof. Manju Mehta, clinical psychologist, All India Institute of Medical Sciences, New Delhi (AIIMS) for her help in psychological analysis of the study. We are highly acknowledged to Research and Development Grant, University of Delhi, New Delhi and Department of Biotechnology (DBT), Ministry of Science and Technology, New Delhi, India for financial assistance. We also acknowledge the cooperation of Prof. V.R.Rao and Prof P.K Ghosh as Co- investigators.

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Correspondence to Kallur Nava Saraswathy.

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Kaur, G., Gaur, R., Thakur, M.K. et al. Depression and one carbon metabolic pathway: A study among a mendelian population from North India. Curr Psychol 40, 1280–1286 (2021).

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  • Depression
  • MTHFR C677T gene polymorphism
  • Vitamin B12 deficiency
  • Folate deficiency. Hyperhomocysteinemia