Abstract
Purpose of Review
This report aims to define the clinical and anatomic variables key in determining patient suitability for transcatheter mitral valve therapies.
Recent Findings
Candidacy for transcatheter mitral valve repair requires weighing the clinical variables that may impact the ability to improve patient symptoms and prolong survival that include left ventricular ejection fraction, symptom severity, pulmonary hypertension, and magnitude of residual regurgitation or stenosis. Individualized selection of transcatheter repair or replacement based on patho-anatomy is being explored. The primary goal is achieving significant reduction in mitral regurgitation.
Summary
Transcatheter mitral valve replacement requires rigorous anatomic screening using computed tomography and candidates should be able to take oral anticoagulation. Selection of patients for transcatheter mitral valve repair is complex and requires intimate knowledge of clinical variables and specific device limitations.
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Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano M. Burden of valvular heart diseases: a population-based study. Lancet. 2006;368:1005–11.
Dziadzko V, Clavel M-A, Dziadzko M, et al. Outcome and undertreatment of mitral regurgitation: a community cohort study. Lancet. 2018;391:960–9.
Monteagudo Ruiz JM, Galderisi M, Buonauro A, et al. Overview of mitral regurgitation in Europe: results from the European Registry of mitral regurgitation (EuMiClip). Eur Heart J Cardiovasc Imaging 2018:jey011-jey.
Regueiro A, Granada JF, Dagenais F, Rodés-Cabau J. Transcatheter mitral valve replacement: insights from early clinical experience and future challenges. J Am Coll Cardiol. 2017;69:2175–92.
Maisano F, Alfieri O, Banai S, et al. The future of transcatheter mitral valve interventions: competitive or complementary role of repair vs. replacement? Eur Heart J. 2015;36:1651–9.
Ling LH, Enriquez-Sarano M, Seward JB, et al. Early surgery in patients with mitral regurgitation due to flail leaflets: a long-term outcome study. Circulation. 1997;96:1819–25.
Suri RM, Schaff HV, Enriquez-Sarano M. Mitral valve repair in asymptomatic patients with severe mitral regurgitation: pushing past the tipping point. Semin Thorac Cardiovasc Surg. 2014;26:95–101.
Ghoreishi M, Evans CF, DeFilippi CR, et al. Pulmonary hypertension adversely affects short- and long-term survival after mitral valve operation for mitral regurgitation: Implications for timing of surgery. J Thorac Cardiovasc Surg. 142:1439–52.
Asgar AW, Mack MJ, Stone GW. Secondary mitral regurgitation in heart failure: pathophysiology, prognosis, and therapeutic considerations. J Am Coll Cardiol. 2015;65:1231–48.
Bach DS, Bolling SF. Improvement following correction of secondary mitral regurgitation in end-stage cardiomyopathy with mitral annuloplasty. Am J Cardiol. 1996;78:966–9.
Wu AH, Aaronson KD, Bolling SF, Pagani FD, Welch K, Koelling TM. Impact of mitral valve annuloplasty on mortality risk in patients with mitral regurgitation and left ventricular systolic dysfunction. J Am Coll Cardiol. 2005;45:381–7.
Goldstein D, Moskowitz AJ, Gelijns AC, et al. Two-year outcomes of surgical treatment of severe ischemic mitral regurgitation. N Engl J Med. 2016;374:344–53.
Rossi A, Dini FL, Faggiano P, et al. Independent prognostic value of functional mitral regurgitation in patients with heart failure. A quantitative analysis of 1256 patients with ischaemic and non-ischaemic dilated cardiomyopathy. Heart. 2011;97:1675–80.
de Marchena E, Badiye A, Robalino G, et al. Respective prevalence of the different carpentier classes of mitral regurgitation: a stepping stone for future therapeutic research and development. J Card Surg. 2011;26:385–92.
Giannini C, Fiorelli F, De Carlo M, et al. Comparison of percutaneous mitral valve repair versus conservative treatment in severe functional mitral regurgitation. Am J Cardiol. 2016;117:271–7.
D'Ascenzo F, Moretti C, Marra WG, et al. Meta-analysis of the usefulness of Mitraclip in patients with functional mitral regurgitation. Am J Cardiol. 2015;116:325–31.
Nishimura RA, Otto CM, Bonow RO, et al. 2014 AHA/ACC guideline for the Management of Patients with Valvular Heart Disease: executive summary: a report of the American College of Cardiology/American Heart Association task force on practice guidelines. Circulation. 2014;129:2440–92.
Azzalini L, Millan X, Khan R, et al. Impact of left ventricular function on clinical outcomes of functional mitral regurgitation patients undergoing transcatheter mitral valve repair. Catheter Cardiovasc Interv. 2016;88:1124–33.
Puls M, Lubos E, Boekstegers P, et al. One-year outcomes and predictors of mortality after MitraClip therapy in contemporary clinical practice: results from the German transcatheter mitral valve interventions registry. Eur Heart J. 2016;37:703–12.
Rudolph V, Lubos E, Schluter M, et al. Aetiology of mitral regurgitation differentially affects 2-year adverse outcomes after MitraClip therapy in high-risk patients. Eur J Heart Fail. 2013;15:796–807.
Bozdag-Turan I, Paranskaya L, Birkemeyer R, et al. Percutaneous mitral repair with the MitraClip system in patients with mild-to-moderate and severe heart failure: a single-Centre experience. Cardiovasc Ther. 2014;32:66–73.
Geis NA, Puls M, Lubos E, et al. Safety and efficacy of MitraClip therapy in patients with severely impaired left ventricular ejection fraction: results from the German transcatheter mitral valve interventions (TRAMI) registry. Eur J Heart Fail. 2018;20:598–608.
Lesevic H, Sonne C, Braun D, et al. Acute and midterm outcome after MitraClip therapy in patients with severe mitral regurgitation and left ventricular dysfunction. Am J Cardiol. 2015;116:749–56.
Melisurgo G, Ajello S, Pappalardo F, et al. Afterload mismatch after MitraClip insertion for functional mitral regurgitation. Am J Cardiol. 2014;113:1844–50.
Schau T, Isotani A, Neuss M, et al. Long-term survival after MitraClip<sup>®</sup> therapy in patients with severe mitral regurgitation and severe congestive heart failure: A comparison among survivals predicted by heart failure models. J Cardiol. 2016;67:287–94.
Varghese R, Itagaki S, Anyanwu AC, Milla F, Adams DH. Predicting early left ventricular dysfunction after mitral valve reconstruction: The effect of atrial fibrillation and pulmonary hypertension. J Thorac Cardiovasc Surg. 2014;148:422–7.
Wang J, Han J, Li Y, et al. Preoperative risk factors of medium-term mitral valve repair outcome. Interact Cardiovasc Thorac Surg. 2014;19:946–54.
Murashita T, Okada Y, Kanemitsu H, et al. The impact of preoperative and postoperative pulmonary hypertension on long-term surgical outcome after mitral valve repair for degenerative mitral regurgitation. Ann Thorac Cardiovasc Surg. 2015;21:53–8.
Yzeiraj E, Bijuklic K, Tiburtius C, et al. Tricuspid regurgitation is a predictor of mortality after percutaneous mitral valve edge-to-edge repair. EuroIntervention. 2017;12:e1817–e24.
Tigges E, Blankenberg S, von Bardeleben RS, et al. Implication of pulmonary hypertension in patients undergoing MitraClip therapy: results from the German transcatheter mitral valve interventions (TRAMI) registry. Eur J Heart Fail. 2018;20:585–94.
Barth S, Hautmann MB, Kerber S, et al. Hemodynamic improvement at three months after MitraClipA(R) treatment in end-stage heart failure patients with functional mitral regurgitation. J Heart Valve Dis. 2016;25:475–82.
Dini FL, Conti U, Fontanive P, et al. Right ventricular dysfunction is a major predictor of outcome in patients with moderate to severe mitral regurgitation and left ventricular dysfunction. Am Heart J. 2007;154:172–9.
•• Sorajja P, Vemulapalli S, Feldman T, et al. Outcomes with Transcatheter mitral valve repair in the United States: an STS/ACC TVT registry report. J Am Coll Cardiol. 2017;70:2315–27. This publication provides the most contemporary data regarding transcatheter mitral valve repair.
Toyama K, Ayabe K, Kar S, et al. Postprocedural changes of tricuspid regurgitation after MitraClip therapy for mitral regurgitation. Am J Cardiol. 2017;120:857–61.
Ohno Y, Attizzani GF, Capodanno D, et al. Association of tricuspid regurgitation with clinical and echocardiographic outcomes after percutaneous mitral valve repair with the MitraClip system: 30-day and 12-month follow-up from the GRASP registry. Eur Heart J Cardiovasc Imaging. 2014;15:1246–55.
Frangieh AH, Gruner C, Mikulicic F, et al. Impact of percutaneous mitral valve repair using the MitraClip system on tricuspid regurgitation. EuroIntervention. 2016;11:e1680–e6.
Pighi M, Estevez-Loureiro R, Maisano F, et al. Immediate and 12-month outcomes of ischemic versus nonischemic functional mitral regurgitation in patients treated with MitraClip (from the 2011 to 2012 pilot sentinel registry of percutaneous edge-to-edge mitral valve repair of the European Society of Cardiology). Am J Cardiol. 2017;119:630–7.
Leon MB, Smith CR, Mack MJ, et al. Transcatheter or surgical aortic-valve replacement in intermediate-risk patients. N Engl J Med. 2016;374:1609–20.
Lee DH, Buth KJ, Martin BJ, Yip AM, Hirsch GM. Frail patients are at increased risk for mortality and prolonged institutional care after cardiac surgery. Circulation. 2010;121:973–8.
Metze C, Matzik A-S, Scherner M, et al. Impact of frailty on outcomes in patients undergoing percutaneous mitral valve repair. J Am Coll Cardiol Intv. 2017;10:1920–9.
Schafer U, Maisano F, Butter C, et al. Impact of Preprocedural left ventricular ejection fraction on 1-year outcomes after MitraClip implantation (from the ACCESS-EU phase I, a prospective, multicenter, nonrandomized Postapproval study of the MitraClip therapy in Europe). Am J Cardiol. 2016;118:873–80.
Feldman T, Foster E, Glower DD, et al. Percutaneous repair or surgery for mitral regurgitation. N Engl J Med. 2011;364:1395–406.
Praz F, Spargias K, Chrissoheris M, et al. Compassionate use of the PASCAL transcatheter mitral valve repair system for patients with severe mitral regurgitation: a multicentre, prospective, observational, first-in-man study. Lancet. 2017;390:773–80.
Lesevic H, Karl M, Braun D, et al. Long-term outcomes after MitraClip implantation according to the presence or absence of EVEREST inclusion criteria. Am J Cardiol. 2017;119:1255–61.
Neuss M, Schau T, Isotani A, Pilz M, Schöpp M, Butter C. Elevated mitral valve pressure gradient after MitraClip implantation deteriorates long-term outcome in patients with severe mitral regurgitation and severe heart failure. J Am Coll Cardiol Intv. 2017;10:931–9.
Cheng R, Dawkins S, Tat E, et al. Relation of residual mitral regurgitation despite elevated mitral gradients to risk of heart failure hospitalization after MitraClip repair. Am J Cardiol. 2017;120:1595–600.
Siminiak T, Wu JC, Haude M, et al. Treatment of functional mitral regurgitation by percutaneous annuloplasty: results of the TITAN trial. Eur J Heart Fail. 2012;14:931–8.
Lipiecki J, Siminiak T, Sievert H, et al. Coronary sinus-based percutaneous annuloplasty as treatment for functional mitral regurgitation: the TITAN II trial. Open Heart. 2016;3:e000411.
Tops LF, Van de Veire NR, Schuijf JD, et al. Noninvasive evaluation of coronary sinus anatomy and its relation to the mitral valve annulus: implications for percutaneous mitral annuloplasty. Circulation. 2007;115:1426–32.
Kim J-H, Kocaturk O, Ozturk C, et al. Mitral cerclage Annuloplasty, a novel Transcatheter treatment for secondary mitral valve regurgitation: initial results in swine. J Am Coll Cardiol. 2009;54:638–51.
Nickenig G, Hammerstingl C, Schueler R, et al. Transcatheter mitral Annuloplasty in chronic functional mitral regurgitation: 6-month results with the Cardioband percutaneous mitral repair system. J Am Coll Cardiol Intv. 2016;9:2039–47.
Muller DWM, Farivar RS, Jansz P, et al. Transcatheter mitral valve replacement for patients with symptomatic mitral regurgitation: a global feasibility trial. J Am Coll Cardiol. 2017;69:381–91.
Blackstone EH, Suri RM, Rajeswaran J, et al. Propensity-matched comparisons of clinical outcomes after transapical or transfemoral transcatheter aortic valve replacement: a placement of aortic transcatheter valves (PARTNER)-I trial substudy. Circulation. 2015;131:1989–2000.
Ribeiro HB, Nombela-Franco L, Munoz-Garcia AJ, et al. Predictors and impact of myocardial injury after transcatheter aortic valve replacement: a multicenter registry. J Am Coll Cardiol. 2015;66:2075–88.
• Wang DD, Eng MH, Greenbaum AB, et al. Validating a prediction modeling tool for left ventricular outflow tract (LVOT) obstruction after transcatheter mitral valve replacement (TMVR). Catheter Cardiovasc Interv 2017. Seminal work first describing the a minimum residual left ventricular outflow tract area before left ventricular outflow obstruction occurs..
Greenbaum AB, Condado JF, Eng M, et al. Long or redundant leaflet complicating transcatheter mitral valve replacement: case vignettes that advocate for removal or reduction of the anterior mitral leaflet. Catheter Cardiovasc Interv 2017.
Babaliaros VC, Greenbaum AB, Khan JM, et al. Intentional percutaneous laceration of the anterior mitral leaflet to prevent outflow obstruction during Transcatheter mitral valve replacement: first-in-human experience. JACC Cardiovasc Interv. 2017;10:798–809.
Guerrero M, Wang DD, Himbert D, et al. Short-term results of alcohol septal ablation as a bail-out strategy to treat severe left ventricular outflow tract obstruction after transcatheter mitral valve replacement in patients with severe mitral annular calcification. Catheter Cardiovasc Interv. 2017;90:1220–6.
Cheung A, Webb JG, Barbanti M, et al. 5-year experience with transcatheter transapical mitral valve-in-valve implantation for bioprosthetic valve dysfunction. J Am Coll Cardiol. 2013;61:1759–66.
Ye J, Cheung A, Yamashita M, et al. Transcatheter aortic and mitral valve-in-valve implantation for failed surgical bioprosthetic valves: an 8-year single-center experience. JACC Cardiovasc Interv. 2015;8:1735–44.
Whisenant B, Jones K, Miller D, Horton S, Miner E. Thrombosis following mitral and tricuspid valve-in-valve replacement. J Thorac Cardiovasc Surg. 2015;149:e26–9.
Eng MH, Greenbaum A, Wang DD, et al. Thrombotic valvular dysfunction with transcatheter mitral interventions for postsurgical failures. Catheter Cardiovasc Interv. 2017;90:321–8.
Butnaru A, Shaheen J, Tzivoni D, Tauber R, Bitran D, Silberman S. Diagnosis and treatment of early bioprosthetic malfunction in the mitral valve position due to thrombus formation. Am J Cardiol. 2013;112:1439–44.
Korber MI, Silwedel J, Friedrichs K, et al. Bleeding complications after percutaneous mitral valve repair with the MitraClip. Am J Cardiol. 2018;121:94–9.
Ben-Avi R, Orlov B, Sternik L, et al. Short- and long-term results after prosthetic mitral valve implantation in patients with severe mitral annulus calcification. Interact Cardiovasc Thorac Surg. 2017;24:876–81.
Guerrero M, Urena M, Himbert D, et al. 1-year outcomes of Transcatheter mitral valve replacement in patients with severe mitral annular calcification. J Am Coll Cardiol. 2018;71:1841–53.
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Marvin H. Eng is a proctor for Edwards Lifesciences. Dee Dee Wang is a co-inventor of 3D-imaging software for anatomic analysis in structural heart procedures assigned to Henry Ford Hospital Health System. Dr. Wang also reports consultancy with Edwards Lifesciences and Materialize.
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This article does not contain any studies with human or animal subjects performed by any of the authors.
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Eng, M.H., Wang, D.D. Transcatheter Mitral Valve Therapy: Defining the Patient Who Will Benefit. Curr Cardiol Rep 20, 107 (2018). https://doi.org/10.1007/s11886-018-1058-8
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DOI: https://doi.org/10.1007/s11886-018-1058-8