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Epidemiology of drug hypersensitivity reactions using 6-year national health insurance claim data from Korea

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Abstract

Background Drug hypersensitivity reactions (DHRs) constitute a large portion of adverse drug reactions (ADRs), but studies for DHR incidence based on national data are scarce. Objective This study aimed to estimate the incidence and patterns of DHRs in a Korean population and the associated utilization of medical resources using the national claims data. Setting The retrospective cohort study performed using the national insurance claim database of the Health Insurance Review and Assessment (HIRA) in Korea. Methods The International Classification of Disease 10th revision code was used to identify DHRs with 20 drug induced DHR codes. The claim data with a diagnosis of DHR in the 2009-2014 periods were analyzed. Main outcome and measure The annual incidence and the 6-year incidence rates were calculated. Incidence rate coefficients were analyzed by sex, age, and year. DHRs following with visits of emergency department (ED) or intensive care unit (ICU) were assessed for utilization of medical resources and risk of ER or ICU visits by sex and age Results A total of 535,049 patients with 1,083,507 claims were assessed in the HIRA database for 6 years. DHR incidence was high in the elderly. The risk of ED and ICU visit with DHR was also higher in the elderly than in the young [highest relative risk, RR of ED 2.59 (1.65–4.07), ICU 5.04 (2.50–10.18)]. DHRs related to blood were high in the young age. Conclusion Incidence of DHRs in the real-world clinical practice was higher in the elderly and female. Clinical consequence was more severe in the elderly.

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References

  1. Thong BY, Tan T. Epidemiology and risk factors for drug allergy. Br J Clin Pharmacol. 2011;71:684–700.

    Article  Google Scholar 

  2. Kongkaew C, Noyce PR, Ashcroft DM. Hospital admissions associated with adverse drug reactions: a systematic review of prospective observational studies. Ann Pharmacother. 2008;42:1017–25.

    Article  Google Scholar 

  3. Demoly P, Hillaire-Buys D. Classification and epidemiology of hypersensitivity drug reactions. Immunol Allergy Clin North Am. 2004;24:345–56.

    Article  Google Scholar 

  4. Edwards IR, Aronson JK. Adverse drug reactions: definitions, diagnosis, and management. Lancet. 2000;356:1255–9.

    Article  CAS  Google Scholar 

  5. Demoly P, Adkinson NF, Brockow K, Castells M, Chiriac AM, Greenberger PA, et al. International consensus on drug allergy. Allergy. 2014;69:420–37.

    Article  CAS  Google Scholar 

  6. Doña I, Barrionuevo E, Blanca-Lopez N, Torres M, Fernandez T, Mayorga C, et al. Trends in hypersensitivity drug reactions: more drugs, more response patterns, more heterogeneity. J Investig Allergol Clin Immunol. 2014;24:143–53.

    Google Scholar 

  7. Gomes ER, Demoly P. Epidemiology of hypersensitivity drug reactions. Curr Opin Allergy Clin Immunol. 2005;5:309–16.

    Article  Google Scholar 

  8. Budnitz DS, Pollock DA, Weidenbach KN, Mendelsohn AB, Schroeder TJ, Annest JL. National surveillance of emergency department visits for outpatient adverse drug events. JAMA. 2006;296:1858–66.

    Article  CAS  Google Scholar 

  9. Turner PJ, Gowland MH, Sharma V, Ierodiakonou D, Harper N, Garcez T, et al. Increase in anaphylaxis-related hospitalizations but no increase in fatalities: an analysis of United Kingdom national anaphylaxis data, 1992–2012. J Allergy Clin Immunol. 2015;135(956–63):e1.

    Google Scholar 

  10. Heinzerling L, Tomsitz D, Anliker M. Is drug allergy less prevalent than previously assumed? A 5-year analysis. Br J Dermatol. 2012;166:107–14.

    Article  CAS  Google Scholar 

  11. Kim B, Kim J, Kang M, Yang M, Park H, Min K, et al. Allergies are still on the rise? A 6-year nationwide population-based study in Korea. Allergol Int. 2016;65:186–91.

    Article  Google Scholar 

  12. Lee CH, Kim J, Jang EJ, Kim YJ, Choi S, Lee JH, et al. Healthcare utilisation by pregnant patients with asthma in South Korea: a cohort study using nationwide claims data. BMJ Open. 2015;5:e008416.

    Article  Google Scholar 

  13. Kim JY, Lee J, Ko Y, Shin J, Jung S, Choi N, et al. Multi-indication carbamazepine and the risk of severe cutaneous adverse drug reactions in Korean elderly patients: a Korean health insurance data-based study. PLoS ONE. 2013;8:e83849.

    Article  Google Scholar 

  14. Stausberg J, Hasford J. Drug-related admissions and hospital-acquired adverse drug events in Germany: a longitudinal analysis from 2003 to 2007 of ICD-10-coded routine data. BMC Health Serv Res. 2011;11:134.

    Article  Google Scholar 

  15. Stausberg J, Hasford J. Identification of adverse drug events. Dtsch Arztebl Int. 2010;107:23–9.

    PubMed  PubMed Central  Google Scholar 

  16. Benkhaial A, Kaltschmidt J, Weisshaar E, Diepgen TL, Haefeli WE. Prescribing errors in patients with documented drug allergies: comparison of ICD-10 coding and written patient notes. Pharm World Sci. 2009;31:464–72.

    Article  Google Scholar 

  17. Vandenbroucke JP, Pearce N. Incidence rates in dynamic populations. Int J Epidemiol. 2012;41:1472–9.

    Article  Google Scholar 

  18. Roujeau J, Haddad C, Paulmann M, Mockenhaupt M. Management of nonimmediate hypersensitivity reactions to drugs. Immunol Allergy Clin North Am. 2014;34:473–87.

    Article  Google Scholar 

  19. Çelik G, Karakaya G, Öztürk A, Gelincik A, Abadoğlu Ö, Sin A, et al. Drug allergy in tertiary care in Turkey: results of a national survey. The ADAPT study: adult drug allergy perception in Turkey. Allergol Immunopathol. 2014;42:573–9.

    Article  Google Scholar 

  20. Dodiuk-Gad RP, Laws PM, Shear NH. Epidemiology of severe drug hypersensitivity. Semin Cutan Med Surg. 2014;33:2–9.

    Article  Google Scholar 

  21. Chung WH, Wang CW, Dao RL. Severe cutaneous adverse drug reactions. J Dermatol. 2016;43:758–66. https://doi.org/10.1111/1346-8138.13430.

    Article  CAS  PubMed  Google Scholar 

  22. Kano Y, Tohyama M, Aihara M, Matsukura S, Watanabe H, Sueki H, et al. Sequelae in 145 patients with drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms: Survey conducted by the Asian Research Committee on Severe Cutaneous Adverse Reactions (ASCAR). J Dermatol. 2015;42:276–82.

    Article  Google Scholar 

  23. Yang MS, Kang MG, Jung JW, Song WJ, Kang HR, Cho SH, et al. Clinical features and prognostic factors in severe cutaneous drug reactions. Int Arch Allergy Immunol. 2013;162:346–54.

    Article  CAS  Google Scholar 

  24. Victor FC, Cohen DE, Soter NA. A 20-year analysis of previous and emerging allergens that elicit photoallergic contact dermatitis. J Am Acad Dermatol. 2010;62:605–10.

    Article  CAS  Google Scholar 

  25. Gomes ER, Kuyucu S. Epidemiology and risk factors in drug hypersensitivity reactions. Curr Treat Options Allergy. 2017;4:239–57.

    Article  Google Scholar 

  26. Hierro Santurino B, Mateos Conde J, Cabero Moran MT, Miron Canelo JA, Armentia Medina A. A predictive model for the diagnosis of allergic drug reactions according to the medical history. J Allergy Clin Immunol Pract. 2016;4(292–300):e3.

    Google Scholar 

  27. Rubio M, Bousquet P, Gomes E, Romano A, Demoly P. Results of drug hypersensitivity evaluations in a large group of children and adults. Clin Exp Allergy. 2012;42:123–30.

    Article  CAS  Google Scholar 

  28. Batzing-Feigenbaum J, Schulz M, Schulz M, Hering R, Kern WV. Outpatient antibiotic prescription. Dtsch Arztebl Int. 2016;113:454–9.

    PubMed  PubMed Central  Google Scholar 

  29. Yoon YK, Park GC, An H, Chun BC, Sohn JW, Kim MJ. Trends of antibiotic consumption in Korea according to national reimbursement data (2008–2012): a population-based epidemiologic study. Medicine (Baltimore). 2015;94:e2100.

    Article  CAS  Google Scholar 

  30. Schmidt M, Hallas J, Friis S. Potential of prescription registries to capture individual-level use of aspirin and other nonsteroidal anti-inflammatory drugs in Denmark: trends in utilization 1999–2012. Clin Epidemiol. 2014;6:155–68.

    Article  Google Scholar 

  31. Garratty G. Immune hemolytic anemia associated with drug therapy. Blood Rev. 2010;24:143–50.

    Article  CAS  Google Scholar 

  32. Sokol RJ, Hewitt S, Stamps BK, Hitchen PA. Autoimmune haemolysis in childhood and adolescence. Acta Haematol. 1984;72:245–57.

    Article  CAS  Google Scholar 

  33. Black C, Tagiyeva-Milne N, Helms P, Moir D. Pharmacovigilance in children: detecting adverse drug reactions in routine electronic healthcare records. A systematic review. Br J Clin Pharmacol. 2015;80:844–54.

    Article  Google Scholar 

  34. Sullivan JE, Farrar HC. Section on clinical pharmacology and therapeutics, committee on drugs. Fever and antipyretic use in children. Pediatrics. 2011;127:580–7.

    Article  Google Scholar 

  35. Stockwell MS, Broder K, LaRussa P, Lewis P, Fernandez N, Sharma D, et al. Risk of fever after pediatric trivalent inactivated influenza vaccine and 13-valent pneumococcal conjugate vaccine. JAMA Pediatr. 2014;168:211–9.

    Article  Google Scholar 

  36. Piram M, Mahr A. Epidemiology of immunoglobulin A vasculitis (Henoch–Schonlein): current state of knowledge. Curr Opin Rheumatol. 2013;25:171–8.

    Article  CAS  Google Scholar 

  37. Jarukitsopa S, Hoganson DD, Crowson CS, Sokumbi O, Davis MD, Michet CJ, et al. Epidemiology of systemic lupus erythematosus and cutaneous lupus erythematosus in a predominantly white population in the United States. Arthritis Care Res. 2015;67:817–28.

    Article  Google Scholar 

  38. Mitsuhata H, Matsumoto S, Hasegawa J. The epidemiology and clinical features of anaphylactic and anaphylactoid reactions in the perioperative period in Japan. Masui. 1992;41:1664–9.

    CAS  PubMed  Google Scholar 

  39. Gibbs N, Sadleir P, Clarke R, Platt P. Survival from perioperative anaphylaxis in Western Australia 2000–2009. Br J Anaesth. 2013;111:589–93.

    Article  CAS  Google Scholar 

  40. Light KP, Lovell AT, Butt H, Fauvel NJ, Holdcroft A. Adverse effects of neuromuscular blocking agents based on yellow card reporting in the U.K.: are there differences between males and females? Pharmacoepidemiol Drug Saf. 2006;15:151–60.

    Article  CAS  Google Scholar 

  41. Hepner DL, Castells MC. Anaphylaxis during the perioperative period. Anesth Analg. 2003;97:1381–95.

    Article  Google Scholar 

  42. Volcheck GW, Mertes PM. Local and general anesthetics immediate hypersensitivity reactions. Immunol Allergy Clin North Am. 2014;34:525–46.

    Article  Google Scholar 

  43. Yu S-J, Gang I-S. A comparative study on the process of hospital visits according to the characteristics of the elderly visiting to emergency medical centers. Korean J Health Serv Manag. 2014;8:27–39.

    Article  Google Scholar 

  44. Nates JL, Nunnally M, Kleinpell R, Blosser S, Goldner J, Birriel B, et al. ICU admission, discharge, and triage guidelines: 000 framework to enhance clinical operations, development of institutional policies, and further research. Crit Care Med. 2016;44:1553–602.

    Article  Google Scholar 

  45. Sekula P, Dunant A, Mockenhaupt M, Naldi L, Bavinck JNB, Halevy S, et al. Comprehensive survival analysis of a cohort of patients with Stevens-Johnson syndrome and toxic epidermal necrolysis. J Investig Dermatol. 2013;133:1197–204.

    Article  CAS  Google Scholar 

  46. Chen YC, Huang HH, Fan JS, Chen MH, Hsu TF, Yen DH, et al. Comparing characteristics of adverse drug events between older and younger adults presenting to a Taiwan emergency department. Medicine (Baltimore). 2015;94:e547.

    Article  CAS  Google Scholar 

  47. Tanno LK, Calderon MA, Goldberg BJ, Akdis CA, Papadopoulos NG, Demoly P. Categorization of allergic disorders in the new World Health Organization International Classification of Diseases. Clin Transl Allergy. 2014;4:42.

    Article  Google Scholar 

  48. Tanno LK, Calderon MA, Goldberg BJ, Gayraud J, Bircher AJ, Casale T, et al. Constructing a classification of hypersensitivity/allergic diseases for ICD-11 by crowdsourcing the allergist community. Allergy. 2015;70:609–15.

    Article  CAS  Google Scholar 

  49. Tanno LK, Calderon M, Papadopoulos NG, Demoly P, EAACI/WAO Task force of a Global Classification of Hypersensitivity/Allergic diseases. Mapping hypersensitivity/allergic diseases in the International Classification of Diseases (ICD)-11: cross-linking terms and unmet needs. Clin Transl Allergy. 2015;5:20.

    Article  Google Scholar 

  50. Tanno LK, Calderon MA, Demoly P. Joint Allergy Academies. New allergic and hypersensitivity conditions section in the International Classification of Diseases-11. Allergy Asthma. Immunol Res. 2016;8:383–8.

    Google Scholar 

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Funding

This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation funded by the Ministry of Science, ICT & Future Planning, Republic of Korea (No. 2013M3A9B5075838).

Conflicts of interest

The authors have no conflicts of interest that are directly relevant to the content of this study.

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Authors and Affiliations

  1. Division of Clinical Pharmacy, College of Pharmacy, Ajou University, Suwon, Republic of Korea

    JaeEun Han & Sukhyang Lee

  2. Department of Pharmacy, Ajou University Hospital, Suwon, Republic of Korea

    JaeEun Han

  3. Department of Allergy, College of Medicine, Ajou University, Suwon, Republic of Korea

    Young-Min Ye

  4. Division of Clinical Pharmacy Practice Education, Ajou University Hospital, Suwon, Republic of Korea

    Sukhyang Lee

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  1. JaeEun Han
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Correspondence to Sukhyang Lee.

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Han, J., Ye, YM. & Lee, S. Epidemiology of drug hypersensitivity reactions using 6-year national health insurance claim data from Korea. Int J Clin Pharm 40, 1359–1371 (2018). https://doi.org/10.1007/s11096-018-0625-9

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