International Journal of Clinical Pharmacy

, Volume 37, Issue 6, pp 1021–1027 | Cite as

Potential drug–drug interactions in oncological adult inpatients at a Spanish hospital: epidemiology and risk factors

  • Mª Ángeles Fernández de Palencia EspinosaEmail author
  • Mª Sacramento Díaz Carrasco
  • José Luis Alonso Romero
  • Amelia de la Rubia Nieto
  • Alberto Espuny Miró
Short Research Report


Background Oncological patients are at high risk for drug–drug interactions (DDIs), which may contribute to therapeutic failure or lead to serious adverse events. Objective To determine the prevalence of potential DDIs in medication lists, to describe the most frequent DDIs and to investigate the possible risk factors associated with them. A prospective cohort study was performed at the Oncology Department of a tertiary hospital over a 12-week period. Twice a week, every inpatient’s treatment sheet was collected and screened through two databases: Micromedex™ and Drug Interaction Facts™. All identified potential DDIs with a moderate or higher severity rating were recorded. Multivariate analysis was used to identify risk factors associated with DDIs. Result A total of 1956 DDIs were detected in 699 treatment sheets. The prevalence of treatment sheets with DDIs was 81.0 % and 32.6 % by Micromedex™ and Drug Interaction Facts™, respectively. Central nervous depressant agents and antiemetics were the most commonly involved groups in DDIs. A higher number of non-antineoplastic drugs was related with potential DDIs [adjusted-OR 1.398 and 1.613 by Micromedex™ and Drug Interaction Facts™, respectively]. Conclusion The prevalence of potential DDIs was widely variable among databases. The main risk factor associated with DDIs was a higher number of non-antineoplastic medicines.


Adult Antineoplastic agent Drug-drug interaction Inpatient Spain 



The study received no special funding.

Conflicts of interest



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Copyright information

© Koninklijke Nederlandse Maatschappij ter bevordering der Pharmacie 2015

Authors and Affiliations

  • Mª Ángeles Fernández de Palencia Espinosa
    • 1
    Email author
  • Mª Sacramento Díaz Carrasco
    • 1
  • José Luis Alonso Romero
    • 2
  • Amelia de la Rubia Nieto
    • 1
  • Alberto Espuny Miró
    • 3
  1. 1.Servicio de FarmaciaHospital Clínico Universitario Virgen de la ArrixacaMurciaSpain
  2. 2.Servicio de OncologíaHospital Clínico Universitario Virgen de la ArrixacaMurciaSpain
  3. 3.Departamento de FarmacologíaUniversidad de MurciaMurciaSpain

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