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Adverse drug reactions experience in a teaching hospital in Jordan

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Abstract

Background Adverse drug reactions (ADRs) represent a major health care problem. Objective To identify the most common ADRs, drugs implicated in ADRs, and to assess their causality, severity, preventability and risk factors predisposing to reported ADRs in Jordan. Setting Al-Karak teaching hospital, southern of Jordan. Method A cross sectional observational study was carried out for 11 months from January to November 2013. Suspected ADRs were recorded in ADRs report forms and analyzed for causality, severity, and preventability. Main outcome measure: Most common ADRs, drugs involved in these ADRs, causality, severity, and preventability of suspected ADRs. Results A total of 64 reports were received. Some patients suffered more than one ADR. The total number of ADRs identified was 108. Forty one drugs were involved in causing these ADRs. About 2/3 of adverse reactions (73.4 %) did not cause admission to the hospital, whereas 26.6 % of the ADRs resulted in admission. Majority of the ADRs were type A (62.5 %). Most of ADRs (92.2 %) were assessed as probable. Nearly, 65.6 % of ADRs were categorized as mild. Majority of ADRs were assessed as “not preventable” (75 %). The most common classes of drugs involved in ADRs were antibiotics, analgesics, vaccines and antiepileptics. The most commonly identified ADRs were abdominal pain, skin rash, shortness of breath, fever, upper gastrointestinal bleeding and vomiting. Risk factors contributed to ADRs were age and polypharmacy. Conclusion Jordanian healthcare providers should be aware of the importance of detecting and reporting ADRs, in order to prevent and reduce the incidence of ADRs. Awareness of risk factors predisposing to ADRs may help in identifying patients with higher risk and therefore reducing the risk of these ADRs and improving patient outcome.

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References

  1. Sultana J, Cutroneo P, Trifirò G. Clinical and economic burden of adverse drug reactions. J Pharmacol Pharmacother. 2013;4(suppl 1):s73–7.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Howard R, Avery A, Slavenburg S, et al. Which drugs cause preventable admissions to hospital? A systematic review. Br J Clin Pharmacol. 2007;63:136–47.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  3. Pirmohamed M, James S, Meakin S, et al. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. BMJ. 2004;329:15–9.

    Article  PubMed Central  PubMed  Google Scholar 

  4. Budnitz D, Shehab N, Kegler S, Richards C. Medication use leading to emergency department visits for adverse drug events in older adults. Ann Intern Med. 2007;147:755–65.

    Article  PubMed  Google Scholar 

  5. Routledge P, O’Mahony M, Woodhouse K. Adverse drug reactions in elderly patients. Br J Clin Pharmacol. 2004;57:121–6.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Davies E, Green C, Taylor S, Williamson P, Mottram D, Pirmohamed M. Adverse drug reactions in hospital in-patients: a prospective analysis of 3695 patient-episodes. PLoS One. 2009;4:e4439.

    Article  PubMed Central  PubMed  Google Scholar 

  7. Lazarou J, Pomeranz B, Corey P. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA. 1998;279:1200–5.

    Article  CAS  PubMed  Google Scholar 

  8. Alsbou M. Incidence of adverse drug reactions in Alkarak governmental hospital: a pilot study. J Med J. 2010;44(4):444–6.

    Google Scholar 

  9. Gharaibeh M, Zmeili S, Abu-rajab A, Daoud Z. Drug-induced admissions to medical wards at Jordan University Hospital. Int J Clin Pharmacol Ther. 1998;36(9):478–82.

    CAS  PubMed  Google Scholar 

  10. World Health Organisation. International drug monitoring. The role of national centres Technical Report Series WHO 1972; 425:1–25.

  11. Jordan National Drug Formulary, version 2, 2011. www.jfda.jo/jndfbook/index.htm.

  12. Naranjo C, Busto U, Sellers E, Sandor P, Roberts E. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30:239–45.

    Article  CAS  PubMed  Google Scholar 

  13. Hartwig S, Siegel J, Schneider P. Preventability and severity assessment in reporting adverse drug reactions. Am J Hosp Pharm. 1992;49:2229–32.

    CAS  PubMed  Google Scholar 

  14. Schumock G, Thornton J. Focusing on the preventability of adverse drug reactions. Hosp Pharm. 1992;27(6):538.

    CAS  PubMed  Google Scholar 

  15. Rawlins M, Thomson J. Mechanisms of adverse drug reactions. In: Davies DM, editor. Textbook of adverse drug reactions. Oxford: Oxford University Press; 1991. pp. 18–45.

    Google Scholar 

  16. Alexopoulou A, Dourakis S, Mantzoukis D, et al. Adverse drug reactions as a cause of hospital admissions: a 6-month experience in a single center in Greece. Eur J Intern Med. 2008;19:505–10.

    Article  PubMed  Google Scholar 

  17. Mandavi CS, Sachdev A, Tiwari P. Adverse drug reactions & their risk factors among Indian ambulatory elderly patients. Indian J Med Res. 2012;136:404–10.

    PubMed Central  CAS  Google Scholar 

  18. Mrugank B, Hareesha R. Prospective observational, non-randomized, parallel sequence study for assessment of adverse drug reactions due to chemotherapeutic treatment in different types of cancer patients. IJPSR. 2013;4(1):386–91.

    Google Scholar 

  19. Bates D, Cullen D, Laird N, Peterson L, Small S, Servi D. Incidence of adverse drug events and potential adverse drug events. Implications for prevention. ADE Prevention Study Group. JAMA. 1995;274:29–34.

    Article  CAS  PubMed  Google Scholar 

  20. Pearson T, Pittman D, Longley J, Grapes Z, Vigliotti D, Mullis S. Factors associated with preventable adverse drug reactions. Am J Hosp Pharm. 1994;51:2268–72.

    CAS  PubMed  Google Scholar 

  21. Seeger J, Schumock G, Kong S. Estimating the rate of adverse drug reactions with capture-recapture analysis. Am J Health-Syst Pharm. 1996;53:178–81.

    CAS  PubMed  Google Scholar 

  22. Raut A, Patel P, Patel C, Pawar A. Preventability, predictability and seriousness of adverse drug reactions amongst medicine inpatients in a teaching hospital: a prospective observational study. Int J Pharma Chem Sci. 2012;1(3):944–50.

    Google Scholar 

  23. Howard R, Avery A, Howard P, Partridge M. Investigation into the reasons for preventable drug related admissions to a medical admissions unit: observational study. Qual Saf Health Care. 2003;12:280–5.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  24. Hawcutt D, Mainie P, Riordan A, Smyth R, Pirmohamed P. Reported paediatric adverse drug reactions in the UK 2000–2009. Br J Clin Pharmacol. 2011;73:437–66.

    Article  PubMed Central  Google Scholar 

  25. Dormann H, Muth-Selbach U, Krebs S, et al. Incidence and costs of adverse drug reactions during hospitalization. Drug Saf. 2000;22(2):161–8.

    Article  CAS  PubMed  Google Scholar 

  26. Hawkey C, Langman M. Non-steroidal anti-inflammatory drugs: overall risks and management. Complementary roles for COX-2 inhibitors and proton pump inhibitors. Gut. 2003;52:600–8.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  27. Blower A, Brooks A, Fenn G, et al. Emergency admissions for upper gastrointestinal disease and their relation to NSAIDs use. Aliment Pharmacol Ther. 1997;11:283–91.

    Article  CAS  PubMed  Google Scholar 

  28. Khan L, Al-Harthi S, Saadah O. Adverse drug reactions in hospitalized pediatric patients of Saudi Arabian University Hospital and impact of pharmacovigilance in reporting ADR. Saudi Pharm J. 2013;21:261–6.

    Article  PubMed Central  PubMed  Google Scholar 

  29. Nguyen J, Fouts M, Kotabe S. Polypharmacy as a risk factor for adverse drug reactions in geriatric nursing home residents. Am J Geriatr Pharmacother. 2006;4(1):36–41.

    Article  PubMed  Google Scholar 

  30. Routledge P, O’Mahony M, Woodhouse K. Adverse drug reactions in elderly patients. Br J Clin Pharmacol. 2003;57:121–6.

    Article  Google Scholar 

  31. Mangoni A, Jackson SH. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol. 2003;57(1):6–14.

    Article  Google Scholar 

Download references

Acknowledgments

The authors would like to thank physicians, pharmacists and nurses at Alkarak Hospital for their help and support.

Funding

The authors received no funding for this study.

Conflicts of interest

The authors declare no conflict of interests.

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, Mutah University, Al-Karak, Jordan

    Mohammed Alsbou & Yousef Alsaraireh

  2. Department of Clinical Pharmacy and Biopharmaceutics, Faculty of Pharmacy, Jordan University, Amman, Jordan

    Sameh Alzubiedi

  3. Department of Microbiology and Immunology, Faculty of Medicine, Mutah University, Al-Karak, Jordan

    Hamed Alzobi & Amin Aqel

  4. Department of Continuous Medical Education, Alkarak Governmental Hospital, Al-Karak, Jordan

    Nawal Abu Samhadanah

  5. Department of Anatomy, Faculty of Medicine, Mutah University, Al-Karak, Jordan

    Omar Alrawashdeh

  6. Department of Ophthalmology, Faculty of Medicine, Mutah University, Al-Karak, Jordan

    Khalil Al-Salem

Authors
  1. Mohammed Alsbou
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  2. Sameh Alzubiedi
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  3. Hamed Alzobi
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  4. Nawal Abu Samhadanah
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  5. Yousef Alsaraireh
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  6. Omar Alrawashdeh
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  7. Amin Aqel
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  8. Khalil Al-Salem
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Correspondence to Mohammed Alsbou.

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Alsbou, M., Alzubiedi, S., Alzobi, H. et al. Adverse drug reactions experience in a teaching hospital in Jordan. Int J Clin Pharm 37, 1188–1193 (2015). https://doi.org/10.1007/s11096-015-0185-1

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  • DOI: https://doi.org/10.1007/s11096-015-0185-1

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