Demonstrating the clinical pharmacist’s activity: validation of an intervention oriented classification system
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Background Clinical pharmacists are increasingly involved in detecting and solving drug-related problems. To document their performance, a convenient tool to code pharmaceutical interventions in daily practice is desirable. The Swiss Society of Public Health Administration and Hospital Pharmacists (GSASA) proposed to implement a new classification system for pharmaceutical interventions. Objectives To develop and validate a classification system for pharmaceutical interventions and to compare it with the well-established Pharmaceutical Care Network Europe (PCNE) system. Setting Rehabilitation clinic, geriatric and orthopaedic wards of a 427-bed teaching hospital. Methods Development of the GSASA classification started with expert panel discussions and the validation of the first version (GSASA V1). To assess appropriateness, interpretability, and validity, clinical pharmacists documented during a 6-week period all interventions using GSASA V1 and PCNE version 6.2 (V6.2). Acceptability and feasibility were tested by an 8-item questionnaire with 5-point Likert scale (1 = strongly disagree, 5 = strongly agree), and inter-rater reliability (Fleiss-Kappa coefficients κ) was determined. After revision, the second version (V2) was assessed again for reliability. Mean outcome measures User’s agreement/satisfaction, comprehensiveness/reliability of the classification system. Results The GSASA V1 includes 4 categories and 35 subcategories. Of 115 interventions classified with GSASA V1, 93 (80.9 %) could be completely classified in all categories. This explains that 3 of 6 users could be not satisfied with the comprehensiveness of GSASA V1 (mean user agreement 2.7 ± 0.8). The questionnaire showed that all users could find GSASA V1 (4.0 ± 0.0) easier to use than PCNE V6.2 (3.0 ± 0.9). Users were generally satisfied with the GSASA V1 (3.5 ± 0.8), especially with the adequate time expenditure (4.0 ± 0.7). Inter-rater reliability and acceptability of GSASA V1 were comparable to those of the PCNE V6.2. The agreement among the GSASA V1 users was substantial for the categories ‘problem’ (κ = 0.66), ‘intervention’ (κ = 0.74), and ‘outcome’ (κ = 0.63), while moderate agreement for the category ‘cause’ was obtained (κ = 0.53). The final system GSASA V2 includes 5 categories (addition of ‘type of problem’) and 41 subcategories. Total inter-rater reliability was moderate (κ = 0.52). Conclusion The GSASA classification system appeared to be reliable and promising for documentation of pharmaceutical interventions in daily practice (practical and less time-consuming). The system is validated in terms of appropriateness, interpretability, validity, acceptability, feasibility, and reliability.
KeywordsClassification system Clinical pharmacy Drug-related problems Pharmaceutical care Pharmaceutical interventions Validation
We thank the participating pharmacists (Dr. Seraina Mengiardi Nemec, Andrea Studer, Markus Messerli, Dr. Fabienne Böni, and Carole Kaufmann) for classifying the cases and answering the questionnaire. We thank Dr. Silvia Rogers and Dr. Claire Jessica Wilson for proof-reading.
No grants from any external funding body were received to conduct this study.
Conflicts of interest
The authors declare that they have no conflicts of interest.
- 1.Pharmaceutical Care Network Europe. Definition drug-related problem. http://www.pcne.org/working-groups/2/drug-related-problems. Accessed 12 Aug 2015.
- 8.Praxiom Research Group Limited. ISO 9000 2005 Plain English Defintions. 2001 [updated 04.05.2014]. http://www.praxiom.com/iso-definition.htm. Accessed 12 Aug 2015.
- 9.Fitzpatrick R, Davey C, Buxton MJ, Jones DR. Evaluating patient-based outcome measures for use in clinical trials. Health Technol Assess. 1998;2(14).Google Scholar
- 12.Pharmaceutical Care Network Europe. Classification for drug related problems V6.2. 2010 [updated 14.01.2010]. http://www.pcne.org/upload/files/11_PCNE_classification_V6-2.pdf. Accessed 12 Aug 2015.
- 15.Ganso M. Verlässlichkeit eines Klassifikationssystems für pharmazeutische Interventionen. Krankenhauspharmazie. 2007;7:273.Google Scholar
- 16.King JE. Resource page: generalized Kappa & other indices of interrater reliability. http://www.ccitonline.org/jking/homepage/interrater.html. Accessed 12 Aug 2015.