Abstract
Creatinine clearance estimation is widely used to evaluate the renal function of the patients in order to initiate or adjust the drugs dosage. However serum creatinine, as a muscle metabolism by-product, may not be a reliable parameter in underweight and/or non-ambulatory patients, such as geriatric, acquired immunodeficiency syndrome patients and bed-confined and cachexic cases. To avoid overestimation of the renal function in those patients, serum cystatin C can be considered as a sensitive and accurate alternative for serum creatinine.
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Keshavarzi, F. Renal function overestimation in underweight and/or non-ambulatory patients. Int J Clin Pharm 37, 675–677 (2015). https://doi.org/10.1007/s11096-015-0157-5
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DOI: https://doi.org/10.1007/s11096-015-0157-5