Evaluation of three brands of drug interaction software for use in intensive care units
- 369 Downloads
Objective To evaluate drug interaction software programs and determine their accuracy in identifying drug-drug interactions that may occur in intensive care units. Setting The study was developed in Brazil. Method Drug interaction software programs were identified through a bibliographic search in PUBMED and in LILACS (database related to the health sciences published in Latin American and Caribbean countries). The programs’ sensitivity, specificity, and positive and negative predictive values were determined to assess their accuracy in detecting drug–drug interactions. The accuracy of the software programs identified was determined using 100 clinically important interactions and 100 clinically unimportant ones. Stockley’s Drug Interactions 8th edition was employed as the gold standard in the identification of drug-drug interaction. Main outcome Sensitivity, specificity, positive and negative predictive values. Results The programs studied were: Drug Interaction Checker (DIC), Drug-Reax (DR), and Lexi-Interact (LI). DR displayed the highest sensitivity (0.88) and DIC showed the lowest (0.69). A close similarity was observed among the programs regarding specificity (0.88–0.92) and positive predictive values (0.88–0.89). The DIC had the lowest negative predictive value (0.75) and DR the highest (0.91). Conclusion The DR and LI programs displayed appropriate sensitivity and specificity for identifying drug–drug interactions of interest in intensive care units. Drug interaction software programs help pharmacists and health care teams in the prevention and recognition of drug–drug interactions and optimize safety and quality of care delivered in intensive care units.
KeywordsBrazil Drug–drug interactions Drug interactions Intensive care units Pharmacotherapy
The Brazilian Coordination for the Improvement of Higher Education Personnel—CAPES funded this research.
Conflicts of interest
- 9.Lam MV, McCart MG, Tsourounis C. An assessment of free, online drug–drug interaction screening programs (DSPs). Hosp Pharm. 2003;38(7):662–8.Google Scholar
- 12.Baxter K (Ed). Stockley’s drug interactions. 8th ed. London: Pharmaceutical Press; 2008. ISBN 978-0-85369-755-8.Google Scholar
- 17.Hammes JA, Pfuetzenreiter F, Silveira F, Koenig A, Westphal GA. Potential drug interactions prevalence in intensive care units. Rev Bras Terap Intensiva. 2008;20(4):349–54.Google Scholar
- 18.Bustamante GDD, Cabrera C, Duran GMG, Medina TJN. Detección de interacciones medicamentosas, em pacientes ingresados a la unidad de cuidados intensivos del Instituto Autônomo Hospital Universitário de los Andes. Vitae Academia Biomédica Digita. 2005;25(7):1–16.Google Scholar
- 19.Gordis L. Epidemiology. 2 ed. Philadelphia: W.B.Saunders Company; 2000. ISBN 0-7216-8338-X.Google Scholar
- 21.Drug checker interaction. Medscape. Available from URL: http://www.medscape.com/druginfo/druginterchecker. Accessed Oct 29 2009.
- 22.Drug Reax system. Micromedex 1. Thomson Reuters (Healthcare). Available from URL: https://www.thomsonhc.com. Accessed Oct 28 2009.
- 23.Drugs.com. Drug interaction checker. Available from URL: http://www.drugs.com/drug_interactions.html. Accessed Oct 29 2009.
- 24.Drugdigest. Check interaction. Available from URL: http://www.drugs.com. Acessed Oct 28 2009.
- 25.Epocrates. Epocrates online. Available from URL: http://www.epocrates.com/. Accessed Oct 27 2009.
- 26.Lexi-comp online. Lexi-interact. Available from URL: http://www.uptodate.com/crlsql/interact/frameset.jsp. Accessed Oct 26 2009.