Abstract
Objective
To determine the sources and the types of information about new drugs that Thai doctors at a teaching hospital perceived as important before prescribing and to assess their views on their preferred sources of drug information.
Method
There were two phases of this study, the quantitative and the qualitative components. For the quantitative study, a descriptive survey using a self-reported questionnaire was mailed. The qualitative component consisted of face-to-face interviews using a semi-structured questionnaire.
Main outcomes measure
The initial sources of information about new drugs; the reliability scores for each source of information; the types of information that doctors required before prescribing new drugs; and the prescribers’ views on their preferred sources.
Results
The general findings regarding the doctors’ information sources on new drugs were consistent in both the quantitative and qualitative analyses. Conferences, medical journals, and meetings with medical representatives were the initial sources of information for new drugs. Safety and efficacy profiles of new drugs were the most common types of information considered before prescribing new medicines. Although the medical representatives were viewed as very efficient in providing information about new drugs, the interviewees perceived that the information obtained from the persons employed by the pharmaceutical companies was likely to be biased. Consequently, the physicians preferred to have an unbiased resource person who could proactively provide two-sided information for both existing and new drugs at the hospital.
Conclusion
The information sources on new drugs most frequently used by the physicians include scientific conferences, journals and medical representatives and they yearn for unbiased information regarding safety and efficacy of the promoted drugs before prescribing the new medicines. Thus, there is a window of opportunity for hospital pharmacists to serve the unmet needs of the physicians.
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References
Williams JR, Hensel PJ. Changes in physicians’ sources of pharmaceutical information: a review and analysis. J Health Care Mark 1991;11(3):46–60.
Haug JD. Physicians’ references for information sources: a meta-analytic study. Bull. Med Libr Assoc 1997;85:223–32.
Relman AS. Separating continuing medical education from pharmaceutical marketing. JAMA 2001;285(15):2009–12.
Angel M. The pharmaceutical industry – to whom is it accountable? NEJM 2000;342(25):1902–4.
Jones MI, Greenfield SM, Bradley CP. Prescribing new drugs: Qualitative study of influences on consultants and general practitioners . Br Med J 2001;323(7309):378–81.
Loke TW, Koh FC, Ward JE. Pharmaceutical advertisement claims in Australian medical publications. Med J Aust 2002;177(6):291–93.
Wilkes MS, Doblin BH, Shapiro MF. Pharmaceutical advertisements in leading medical journals: experts’ assessments. Ann Intern Med 1992;116(11):912–19.
Wade VA, Mansfield PR, McDonald PJ. Drug companies evidence to justify advertising. Lancet 1989;2:1261–64.
Ziegler MG, Lew P, Singer BC. The accuracy of drug information from pharmaceutical sales representatives. JAMA 1995;273(16):1296–98.
Goodman B. Do drug company promotions influence physician behavior?. West J Med 2001;174:232–33.
Kongpatanakul S, Somhom P, Panichpathompong U, Supatchaipisit P, Limcharoensuk S. Physicians’ attitudes toward pharmaceutical sales representatives. Thai J Pharmacol 1997;19(1):23–32.
Hornby AS. New oxford advanced learners’ dictionary of current English, Oxford: Oxford University Press; 2000.
National prescribing service. Case study 18: Considering a new drug. http://www.nps.org.au (18 Jun. 2003).
ACNielsen HCI. Important sources of medical information. http://www.perq-hci.com/News/research/important_sources.pdf (10 Feb. 2005).
Peay MY, Peay ER. Patterns of preference for information sources in the adoption of new drugs by specialists. Soc Sci Med 1990;31(4):467–76.
Manning PR, Denson TA. How internists learned about cimetidine. Ann Intern Med 1980;92:690–92.
Haynes F, Davis D, McKibbon A, et al. A critical appraisal of the efficacy of continuing medical education. JAMA 1982;251(1):61–64.
Wertheimer AI, Levy R, O’Connor T. Too many drugs? The clinical and economic value of incremental innovations. Res Human Cap Dev 2001;14:77–118.
Psaty BM, Furberg CD. COX-2 Inhibitors - Lessons in drug safety. NEJM 2005. http://www.content.nejm.org/cgi/content/abstract/NEJMe058042v1 (17 Feb. 2005).
Spath HM, Charavel M, Morelle M, Carrere MO. A qualitative approach to the use of economic data in the selection of medicines for hospital formularies: a French survey. Pharm World Sci 2003;25(6):269–75.
Lexchin J. What information do physicians receive from pharmaceutical representatives?. Can Fam Physician 1997;41:1293–95.
Monaghan M, Galt K,Turner P, et al. Student understanding of relationship between the health professions and the pharmaceutical industry. Teach Learn Med 2003;15(1):14–20.
Shearer SW, Gagnon JP, Eckel FM. Community, hospital and clinical pharmacists and drug information centers as physician drug information sources. Am J Hosp Pharm 1978;35(8):909–14.
Millonig MK, Jackson TL, Ellis WM. Improving medication use through pharmacists’ access to patient-specific health care information. J Am Pharm Assoc (Wash) 2002;42(4):638–45.
McGettigan P, Golden J, Fryer J, et al. Prescribers prefer people: The sources of information used by doctors for prescribing suggest that the medium is more important than the message. Br J Clin Pharmacol 2001;51(2):184–89.
Avorn J. Pharmacy’s wake-up call. Am J Health Syst Pharm 2004;61(15):2364.
Soumerai SB, Avorn J. Principles of educational outreach (‘academic detailing’) to improve clinical decision making. JAMA 1990;263(4):549–56.
McAvoy B, Kaner E. General practice postal surveys: a questionnaire too far?. Br Med J 1996;313:732–33.
Prakongsai P. Dual practice among public medical doctors in Thailand. http://www.essentialdrugs.org/edrug/achive/200311/msg00018.php.(2 Feb. 2004).
Vichyanond P, Hatchaleelaha S, Jintavorn V, Kerdsomnuig S. How pediatricians manage asthma in Thailand. Pediatr Pulmonol. 2001;32(2):109–14.
Acknowledgements
We acknowledge the tremendous efforts of our research assistants Kacha Kanyalong and Juthamart Suwatthanabunpot in this project. In addition, we thank Dr. Jeff Johns, Cliff Layton as well as the journal reviewers for their helpful comments in contribution to this paper. More importantly, we truly appreciated all the respondents for their generosity and valuable time in sharing their views in this study.
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Appendix
Appendix
Appendix: A
The mailed questionnaires
Appendix: B
Semi-structured interview guideline
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What would you think of if I ask for a drug that is new, branded and promoted in your department?
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How did you first learn about the launch of this new drug?
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When did you start prescribing it?
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Why did you prescribe it?
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How would you know whether this new drug has been listed on the hospital drug formulary?
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Was your decision to start prescribing this new drug influenced by anything or anyone in particular (probing: colleagues, literature, advertising, medical representatives, symposiums, CME, etc.)?
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How often do you see medical representative?
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Which journals do you usually read? Why?
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Which professional meetings/conferences do you like to attend? Why?
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In general, what do you think are the main factors that influence your decision to start prescribing a new, promoted drug?
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Layton, M.R., Sritanyarat, W., Chadbunchachai, S. et al. Sources of information for new drugs among physicians in Thailand. Pharm World Sci 29, 619–627 (2007). https://doi.org/10.1007/s11096-007-9112-4
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DOI: https://doi.org/10.1007/s11096-007-9112-4