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Synthesis of new pyrimidine-containing compounds: 5-(2-(alkylamino)-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)-6-hydroxypyrimidine-2,4(1H,3H)-dione derivatives

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Abstract

In this study, the one-pot reaction between primary amines, 1,1-bis-(methylthio)-2-nitroethene, ninhydrin, and barbituric acid as an enolizable C–H-activated compound provides a simple method for the preparation of 5-(2-(alkylamino)-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)-6-hydroxypyrimidine-2,4(1H,3H)-dione derivatives with potential synthetic and pharmacological interest. This reaction shows attractive characteristics, such as substrate availability, good yields, existence of numerous hydrogen-bonding possibilities in product, and its mild conditions in ethanol media.

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Acknowledgements

Financial support of this research from Imam Khomeini International University, Iran, is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Imam Khomeini International University, Qazvin, Iran

    Khudaidad Kochia, Mohammad Bayat, Shima Nasri & Aref Mohammadi

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  1. Khudaidad Kochia
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  2. Mohammad Bayat
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  3. Shima Nasri
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  4. Aref Mohammadi
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Correspondence to Mohammad Bayat.

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Kochia, K., Bayat, M., Nasri, S. et al. Synthesis of new pyrimidine-containing compounds: 5-(2-(alkylamino)-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)-6-hydroxypyrimidine-2,4(1H,3H)-dione derivatives. Mol Divers 24, 1015–1024 (2020). https://doi.org/10.1007/s11030-019-10009-w

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