Molecular Diversity

, Volume 22, Issue 3, pp 709–722 | Cite as

An efficient protocol for the synthesis of highly sensitive indole imines utilizing green chemistry: optimization of reaction conditions

  • Bushra Nisar
  • Syeda Laila Rubab
  • Abdul Rauf Raza
  • Sobia Tariq
  • Ayesha Sultan
  • Muhammad Nawaz Tahir
Original Article


Novel and highly sensitive indole-based imines have been synthesized. Their synthesis has been compared employing a variety of protocols. Ultimately, a convenient, economical and high yielding set of conditions employing green chemistry have been designed for their synthesis.


Indole Imines Schiff bases Green chemistry 



The authors acknowledge the Higher Education Commission of Pakistan for two research grants (HEC-20-3873 and SRGP-21-1145), research fellowships to Syeda Laila Rubab (074-2373-Ps4-426), Bushra Nisar (074-1727-Ps4-192) and financial support for spectral analysis (NMR and MS) at Quaid-I-Azam University, Islamabad and/or ICCBS, University of Karachi, Karachi. We are grateful to the University of Sargodha for the provision of basic instruments and XRD facility.

Supplementary material

11030_2018_9826_MOESM1_ESM.pdf (2.3 mb)
Supplementary material 1 (pdf 2392 KB)


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Bushra Nisar
    • 1
  • Syeda Laila Rubab
    • 2
  • Abdul Rauf Raza
    • 3
  • Sobia Tariq
    • 3
  • Ayesha Sultan
    • 4
  • Muhammad Nawaz Tahir
    • 5
  1. 1.Department of ChemistryThe University of LahoreSargodhaPakistan
  2. 2.Department of ChemistryUniversity of EducationJauharabadPakistan
  3. 3.Ibn e Sina Block, Department of ChemistryUniversity of SargodhaSargodhaPakistan
  4. 4.Department of ChemistryUniversity of EducationFaisalabadPakistan
  5. 5.Ibn ul Haithum Block, Department of PhysicsUniversity of SargodhaSargodhaPakistan

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