Molecular Diversity

, Volume 15, Issue 1, pp 257–261 | Cite as

Green chemistry approaches to the regioselective synthesis of spiro heterobicyclic rings using iodine as a new and efficient catalyst under solvent-free conditions

  • Dipak Prajapati
  • Debajyoti Bhuyan
  • Mukut Gohain
  • Wenhao Hu
Short Communication


Iodine catalyzes the pseudo four-component reaction of an aldehyde, a urea or thiourea, and cyclic 1,3-dicarbonyl compounds under microwave irradiation in a solvent-free condition to yield various σ symmetric spiro heterobicyclic rings in excellent yields.

Graphical Abstract


Biginelli-like reaction Barbituric acid Spiro fused heterocycles 1, 3-dicarbonyl compounds Iodine MCR Multicomponent Microwave synthesis 


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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Dipak Prajapati
    • 1
  • Debajyoti Bhuyan
    • 1
  • Mukut Gohain
    • 1
  • Wenhao Hu
    • 2
  1. 1.Medicinal Chemistry DivisionNorth East Institute of Science and TechnologyJorhatIndia
  2. 2.Department of ChemistryEast China Normal UniversityShanghaiPeople’s Republic of China

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