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Green chemistry approaches to the regioselective synthesis of spiro heterobicyclic rings using iodine as a new and efficient catalyst under solvent-free conditions

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Abstract

Iodine catalyzes the pseudo four-component reaction of an aldehyde, a urea or thiourea, and cyclic 1,3-dicarbonyl compounds under microwave irradiation in a solvent-free condition to yield various σ symmetric spiro heterobicyclic rings in excellent yields.

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Authors and Affiliations

  1. Medicinal Chemistry Division, North East Institute of Science and Technology, Jorhat, Assam, 785 006, India

    Dipak Prajapati, Debajyoti Bhuyan & Mukut Gohain

  2. Department of Chemistry, East China Normal University, Shanghai, 200062, People’s Republic of China

    Wenhao Hu

Authors
  1. Dipak Prajapati
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  2. Debajyoti Bhuyan
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  3. Mukut Gohain
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  4. Wenhao Hu
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Correspondence to Dipak Prajapati.

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Prajapati, D., Bhuyan, D., Gohain, M. et al. Green chemistry approaches to the regioselective synthesis of spiro heterobicyclic rings using iodine as a new and efficient catalyst under solvent-free conditions. Mol Divers 15, 257–261 (2011). https://doi.org/10.1007/s11030-010-9247-4

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