Abstract
New effective approach to the synthesis of a wide variety of C-2 nitro or aminophenyl substituted quinolines was reported using diverse intermediate 4-(2-oxopyrrolinidyl-1)-tetrahydroquinolines that were prepared by a three component imino Diels-Alder reaction was reported. The key aromatisation process occurs cleanly with the loss of the 2-oxopyrrolinidyl-1 fragment.
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Kouznetsov, V.V., Bohórquez, A.R.R., Saavedra, L.A. et al. An efficient synthesis of new C-2 aryl substituted quinolines based on three component imino Diels-Alder reaction. Mol Divers 10, 29–37 (2006). https://doi.org/10.1007/s11030-006-2344-8
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DOI: https://doi.org/10.1007/s11030-006-2344-8