Molecular Diversity

, Volume 10, Issue 1, pp 29–37 | Cite as

An efficient synthesis of new C-2 aryl substituted quinolines based on three component imino Diels-Alder reaction

  • Vladimir V. Kouznetsov
  • Arnold R. Romero Bohórquez
  • Luis Astudillo Saavedra
  • Ricardo Fierro Medina
Full-lenth Paper


New effective approach to the synthesis of a wide variety of C-2 nitro or aminophenyl substituted quinolines was reported using diverse intermediate 4-(2-oxopyrrolinidyl-1)-tetrahydroquinolines that were prepared by a three component imino Diels-Alder reaction was reported. The key aromatisation process occurs cleanly with the loss of the 2-oxopyrrolinidyl-1 fragment.


C-2 substituted quinolines three component imino Diels-Alder reaction 


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Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  • Vladimir V. Kouznetsov
    • 1
  • Arnold R. Romero Bohórquez
    • 1
  • Luis Astudillo Saavedra
    • 2
  • Ricardo Fierro Medina
    • 3
  1. 1.Laboratorio de Química Orgánica y Biomolecular, Escuela de QuímicaUniversidad Industrial de SantanderBucaramangaUSA
  2. 2.Instituto de Química de Recursos NaturalesUniversidad de TalcaTalcaChile
  3. 3.Laboratorio de Síntesis Orgánica y Organometálicos, Departamento de QuímicaUniversidad Nacional de Colombia, Cuidad Universitaria, BogotáBogotáUSA

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