A Heterometallic MOF for Highly Selective Al3+ Ion Detection and Protective Effect Against Periodontitis by Reducing P. gingivalis CFU and Inflammatory Cytokines Levels

Abstract

By employment of an amide-functionalized tetracarboxylic ligand 5,5′-(carbonylbis(azanediyl))-diisophthalic acid (H4cbab), a new polyhedral metal–organic framework (MOF) with the chemical formula of {[InZn2(cbda)2(H2O)2](NMF)3}n (1, NMF = N-methylformamide) has been synthesized under the solvothermal reaction condition. The structural feature was studied via the single crystal X-ray diffraction along with ultimate analysis. This as-prepared MOF shows excellent luminescence performance which can be able to detect Al3+ ions selectively. In aqueous solutions, the detection limitation for Al3+ ion is 0.56 µM, which is significantly below the highest standard of 7.41 µM for Al3+ ion in drinking water that is defined by the World Health Organization (WHO). The protective effect of compound against periodontitis was further explored. The viable cell counts (CFU) number was counted to evaluate the inhibitory effect of compound on bacterial growth. The enzyme linked immunosorbent assay (ELISA) was carried on in order to measure accurately the proportion of inflammatory cytokines in gingival fluid around the implant. The potential binding modes of the synthesized compounds as well as the targeted protein was explored by calculating docking with high accuracy as well as pose scoring process.

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Acknowledgements

This work was supported by Grants from Scientific Research Topics of Heilongjiang Health Commission (2018-038).

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Correspondence to Yu-Ze Hou.

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Hou, YY., Zhou, LB., Meng, CF. et al. A Heterometallic MOF for Highly Selective Al3+ Ion Detection and Protective Effect Against Periodontitis by Reducing P. gingivalis CFU and Inflammatory Cytokines Levels. J Clust Sci 31, 1285–1293 (2020). https://doi.org/10.1007/s10876-019-01738-x

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Keywords

  • MOF
  • Heterometallic framework
  • Al3+ ion detection
  • Periodontitis
  • Molecular docking