An integrated systems approach to plateau ecosystem management—a scientific application in Qinghai and Tibet plateau
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There is a global trend of the shortage of nature resources, such as water and wildlife, which have suffered dramatic losses due to over-use, pollution, habitat loss, and, increasingly, changes caused by global warming. To make the planet more sustainable, abundant data has to be collected and analyzed from ecosystems for scientific decision-making, restoring and preserving natural resources. In this paper, an integrated systems approach has been proposed for the data acquisition and analysis in information management of an ecosystem; it is a direct extension of an agriculture ecosystem enterprise information system (AEEIS) developed by Xu et al. (Genomics Proteomics Bioinformatics 3:5–17, 2008). The challenges in system development have been discussed, and the significance of the developed system has been illustrated through a thorough discussion and a case study on the genetic coding and expression of antelopes. In the case study, an IoT-based enterprise information system (EIS) has been applied to investigate the effects of the signal transducer and activator of transcription 3 (STAT3) on the adaptation mechanism to high altitude hypoxia. Two remarkable conclusions are (i) the levels of the STAT3 mRNA and protein vary from one tissue to another, and the highest level is in the lung tissue, and (ii) Tibetan antelope’s expression of STAT3 mRNA and protein are higher than that from plain sheep. Based on the fact that a Tibetan antelope has a higher adaptability to hypoxia; it has illustrated that the hypoxic STAT3-specific expression is one of the molecular bases of high altitude hypoxia adaptation in Tibetan antelope.
KeywordsMedical Informatics Enterprise Systems Industrial Information Integration Engineering (IIIE) Internet of Things (IoT) Ecosystem Signal Transducer and Activator of Transcription 3 Genetic Cloning Genetic Expression Hypoxia Adaptation
Agriculture ecosystem enterprise information system
Complementary deoxyribonucleic acid
Deoxyribonucleic acid binding domain
Messenger ribonucleic acid
Manganese superoxide dismutase
Non shivering thermogenesis
Open reading frames
Rapid amplification of cDNA ends
Real-time polymerase chain reaction
Src homology 2 domain
System of systems
Signal transducer and activator of transcription 3
Transcription activation domain
Uncoupling proteins 1
Vascular endothelial growth factor
This project has been supported by the National Basic Research Program of China (Grant No.2012CB518200), the Program of International Science and Technology Cooperation of China (Grant No.2011DFA32720) and the National Natural Science Foundation of China (Grant No.30393133).
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