Abstract
This paper presents the manner in which the DNA, the molecule of life, was discovered. Unlike what many people, even biologists, believe, it was Johannes Friedrich Miescher who originally discovered and isolated nuclein, currently known as DNA, in 1869, 75 years before Watson and Crick unveiled its structure. Also, in this paper we show, and above all demonstrate, the serendipity of this major discovery. Like many of his contemporaries, Miescher set out to discover how cells worked by means of studying and analysing their proteins. During this arduous task, he detected an unexpected substance of unpredicted properties. This new substance precipitated when he added acid to the solution and it dissolved again when adding alkali. Unexpectedly and by a mere fluke, Miescher was the first person to obtain a DNA precipitate. The paper then presents the term serendipity and discusses how it has influenced the discovery of other important scientific milestones. Finally, we address the question of whether serendipitous discoveries can be nurtured and what role the computer could play in this process.
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References
Dahm, R. (2005). Friedrich Miescher and the discovery of DNA. Developmental Biology, 278(2), 274–288.
Dahm, R. (2008a). Discovering DNA: Friedrich miescher and the early years of nucleic acid research. Human Genetics, 385, 565–581.
Dahm, R. (2008b). El descubrimiento del adn. Investigacion y Ciencia, 122(6), 77–85.
De Figueiredo, A. D., Campos, J. (2001). The serendipity equations. In First workshop on creative systems, international conference of case-based reasoning (ICCBR-01), Vancouver (Vol. 30, pp. 121–124). British Columbia: Canada.
De Meuron-Ladolt, M. (1970). Johannes Friedrich Miescher: His personality & the importance of his work. Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften, 25(1–2), 9–24.
Greenstein, J. P. (1943). Friedrich Miescher, 1844–1895. The Scientific Monthly, 57(5), 523–532.
Harbers, E. (1969). On the discovery of DNA by Friedrich Miescher 100 years ago. Deutsche Medizinische Wochenschrift, 94(38), 1948–1949.
James, J. (1970). Miescher’s discoveries of 1869. A centenary of nuclear chemistry. Journal of Histochemistry and Cytochemistry, 18(3), 217–219.
Kantarovich, A., & Ne’eman, Y. (1989). Serendipity as a source of evolutionary progress in science. Studies in the History and Philosophy Science Part A, 20(4), 505–529.
Koll, M. (2000). Information retrieval. Bulletin Jasis, 26(2), http://www.asis.org/Bulletin/Jan-00/track_3.html.
Lagerkvist, U., & Brenner, S. (1998). DNA pioneers and their legacy. New Haven: Yale University Press.
Maderspacher, F. (2004). Rags before the riches: Friedrich Miescher & the discovery of DNA. Human Genetics, 14(15), R608.
Merton, R. K., & Barber, E. G. (2004). The travels and adventures of serendipity: A study in sociological semantics and the sociology of science. Princeton, NJ: Princeton University Press.
Miescher, F. (1871). Ueber die chemische zusammensetzung der eiterzellen. Medicinisch-Chemische Untersuchungen, 4, 441–460.
Miescher, F. (1874). Die spermatozoen einiger wirbeltiere. Ein beitrag zur histochemie. Verhandlungen der naturforschenden Gesellschaft in Basel, VI, 138–208.
Ostrowski, W. (1970). From nucleic acids to DNA. On the 100th anniversary of the discovery of nucleic acids by Friedrich Miescher. Postepy Biochemii, 16(4), 581–587.
Portugal, L. H., & Cohen, J. S. (1977). A century of DNA: A history of the discovery of the structure and function of the genetic substance. Cambridge, MA: MIT Press.
Roberts, R. M. (1989). Serendipity: Accidental discoveries in science. New York: Wiley.
Van Andel, P. (1994). Anatomy of the unsought finding. Serendipity: Origin, history, domains, traditions, appearances, patterns and programmability. British Journal for the Philosophy of Science, 45(2), 631–648.
Watson, J. D., & Crick, F. H. C. (1953). A structure for deoxyribose nucleic acid. Nature, 171(4356), 737–738.
Wolf, G. (2003). Friedrich Miescher: The man who discovered DNA. Chemical Heritage, 21(10–11), 37–41.
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Anguera de Sojo, Á., Ares, J., Martínez, M.A. et al. Serendipity and the Discovery of DNA. Found Sci 19, 387–401 (2014). https://doi.org/10.1007/s10699-014-9348-0
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DOI: https://doi.org/10.1007/s10699-014-9348-0