Abstract
Metastases to the ovary occur in 0.8–9.7 % of colorectal cancer (CRC) cases (Hanna and Cohen in Clin Colorectal Cancer 3(4):215–222, 2004). The need to combine surgical resection of the primary tumor and bilateral oophorectomy is a matter of debate (Erroi et al. in J Surg Oncol 96(2):113–117, 2007). In a consecutive multi-hospital cohort of 30 CRC metastases to the ovary we came across four female patients (13 %; 95 % CI 3.6–34.1) with familial adenomatous polyposis (FAP). This number is high since the estimated incidence of FAP CRC is far below 1 % of all CRC and the expected incidence of FAP CRC that metastasized to the ovaries would thus be almost zero. In a second screen in nationwide databases we found that ovarian metastases occurred in at least 15 % of female FAP CRC cases. We provide now first evidence that especially in female FAP CRC patients bilateral oophorectomy during surgery should be discussed.
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Crobach, S., van Wezel, T., Vasen, H.F. et al. Ovarian metastases of colorectal and duodenal cancer in familial adenomatous polyposis. Familial Cancer 11, 671–673 (2012). https://doi.org/10.1007/s10689-012-9565-z
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DOI: https://doi.org/10.1007/s10689-012-9565-z