Digestive Diseases and Sciences

, Volume 60, Issue 3, pp 664–671 | Cite as

Blood-Based Tests for Colorectal Cancer Screening: Do They Threaten the Survival of the FIT Test?

  • Robert S. Bresalier
  • Scott Kopetz
  • Dean E. Brenner


Colorectal cancer is the second leading cause of cancer death in industrialized nations, accounting for 10 % of the total cancer burden with an individual lifetime risk of ~6 % in the USA (Siegel et al. in CA Cancer J Clin 62:9–29, 2014, American Cancer Society in Colorectal cancer facts and figures 2011–2013. American Cancer Society, Atlanta, 2011, Siegel et al. in CA Cancer J Clin 61:212–236, 2011). Although numerous screening methods have been incorporated into guidelines for colorectal cancer screening, no guideline includes a noninvasive blood-based test as a recommended option.


Colon cancer Screening Blood-based markers Fecal occult blood testing 


Conflict of interest



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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Robert S. Bresalier
    • 1
  • Scott Kopetz
    • 2
  • Dean E. Brenner
    • 3
  1. 1.Department of Gastroenterology, Hepatology and NutritionThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Department of GI Medical OncologyThe University of Texas MD Anderson Cancer CenterHoustonUSA
  3. 3.Department of Medical OncologyThe University of MichiganAnn ArborUSA

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