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Chemistry of Heterocyclic Compounds

, Volume 51, Issue 1, pp 97–101 | Cite as

2,1-Benzothiazine 2,2-dioxides 10*. Reaction of alkyl 1-R-4-hydroxy-2,2-dioxo-1Н-2λ6,1-benzothiazine-3-carboxylates with 1H-1,2,4-triazol-5-amine

  • Igor V. Ukrainets
  • Lidiya A. Petrushova
  • Galina Sim
  • Natalya L. Bereznyakova
Article
  • 89 Downloads

The reaction of alkyl 1-R-4-hydroxy-2,2-dioxo-1Н-2λ6,1-benzothiazine-3-carboxylates with 1H-1,2,4-triazol-5-amine in refluxing xylene produced not only 1-R-4-hydroxy-2,2-dioxo-N-(1H-1,2,4-triazol-5-yl)-1H-2λ6,1-benzothiazine-3-carboxamides, but also 6,6-dioxides of 7-R-3H-[1,2,4]triazolo[5',1':2,3]pyrimido[5,4-c][2,1]benzothiazin-5(7H)-ones.

Keywords

alkyl 4-hydroxy-2,2-dioxo-1Н-2λ6,1-benzothiazine-3-carboxylates 1H-1,2,4-triazol-5-amine amidation heterocyclization 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Igor V. Ukrainets
    • 1
  • Lidiya A. Petrushova
    • 1
  • Galina Sim
    • 2
  • Natalya L. Bereznyakova
    • 1
  1. 1.National University of PharmacyKharkivUkraine
  2. 2.Far Eastern State Medical UniversityKhabarovskRussia

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