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4-Hydroxy-2-quinolones. 221.* Synthesis, structure, and biological activity of 3-(3-(alkylcarbamoyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-1-yl)propanoic acids

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Chemistry of Heterocyclic Compounds Aims and scope

A simple method is proposed and used for preparing a series of 3-(3-alkylcarbamoyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-1-yl)propanoic acids. A comparative analysis was carried out on the analgesic and diuretic properties of these compounds and their synthetic precursors, namely, the corresponding 1-(2-cyanoethyl)-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides.

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References

  1. I. V. Ukrainets, N. Yu. Golik, I. N. Chernenok, S. V. Shishkina, and V. A. Parshikov, Khim. Geterotsikl. Soedin., 1780 (2012). [Chem. Heterocycl. Compd., 48, 1665 (2012)].

    Google Scholar 

  2. A. Kleeman and J. Engel, Pharmaceutical Substances. Synthesis, Patents, Applications, Multimedia Viewer, Version 2.00, Georg Thieme Verlag, Stuttgart (2001).

  3. S. Budavari, M. O’Neil, and A. Smith, The Merck Index on CD-ROM. Version 12:3, Merck & Co. Inc., Chapman & Hall/CRC, Whitehouse Station (2000).

  4. M. D. Mashkovskii, Drugs [in Russian], RIA Novaya Volna: Izd. Umerenkov, Moscow (2009).

  5. Ya. A. Sigidin, G. Ya. Shvarts, A. P. Arzamastsev, and S. S. Liberman, Drug Therapy of Inflammatory Processes (Experimental and Clinical Pharmacology of Anti-Inflammatory Preparations) [in Russian], Meditsina, Moscow (1988), p. 46.

  6. I. V. Ukrainets, L. V. Sidorenko, E. N. Svechnikova, and O. V. Shishkin, Khim. Geterotsikl. Soedin., 1503 (2007). [Chem. Heterocycl. Compd., 43, 1275 (2007)].

    Google Scholar 

  7. I. V. Ukrainets, L. V. Sidorenko, and O. S. Golovchenko, Khim. Geterotsikl. Soedin., 1687 (2007). [Chem. Heterocycl. Compd., 43, 1434 (2007)].

    Google Scholar 

  8. H.-B. Burgi and J. D. Dunitz, Structure Correlation, Vol. 2, VCH, Weinheim (1994), p. 741.

  9. Yu. V. Zefirov, Kristallografiya, 42, 936 (1997).

    CAS  Google Scholar 

  10. M. A. Mokhort, L. V. Yakovleva, and O. M. Shapoval, in: O. V. Stefanov (editor), Preclinical Investigations of Medicinal Agents: Methodological Recommendations [in Ukrainian], Avitsena, Kiev (2001), p. 307.

  11. L. N. Sernov and V. V. Gatsura, Elements of Experimental Pharmacology [in Russian], Moscow (2000), p. 103.

  12. I. V. Ukrainets, N. L. Bereznyakova, L. A. Grinevich, V. E. Kuz’min, and A. G. Artemenko, Khim. Geterotsikl. Soedin., 868 (2010). [Chem. Heterocycl. Compd., 46, 699 (2010)].

    Google Scholar 

  13. I. V. Ukrainets, O. V. Bevz, E. V. Mospanova, L. V. Savchenkova, and S. I. Yankovich, Khim. Geterotsikl. Soedin., 339 (2012). [Chem. Heterocycl. Compd., 48, 320 (2012)].

    Google Scholar 

  14. G. M. Sheldrick, SHELXTL PLUS. PC Version. A System of Computer Programs for the Determination of Crystal Structure from X-Ray Diffraction Data, Rev. 5.1 (1998).

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Authors and Affiliations

  1. National University of Pharmacy, 53 Pushkinska St., Kharkiv, 61002, Ukraine

    I. V. Ukrainets, K. V. Andreeva, O. V. Gorokhova & V. N. Kravchenko

Authors
  1. I. V. Ukrainets
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  2. K. V. Andreeva
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  3. O. V. Gorokhova
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  4. V. N. Kravchenko
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Corresponding author

Correspondence to I. V. Ukrainets.

Additional information

*For communication 220, see [1].

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1932-1940, December, 2012.

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Ukrainets, I.V., Andreeva, K.V., Gorokhova, O.V. et al. 4-Hydroxy-2-quinolones. 221.* Synthesis, structure, and biological activity of 3-(3-(alkylcarbamoyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-1-yl)propanoic acids. Chem Heterocycl Comp 48, 1809–1816 (2013). https://doi.org/10.1007/s10593-013-1213-5

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  • DOI: https://doi.org/10.1007/s10593-013-1213-5

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