Treatment of ethyl 7-hydroxy-5-oxo-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-6-carboxylate with bromine in aqueous acetic acid solution gave not only the expected ethyl 2-bromo-1,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylate, but also an admixture of its 9-bromo-substituted isomer. The structural features of the major and minor reaction products are discussed.
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*For Communication 219, see [1].
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1780-1785, November, 2012.
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Ukrainets, I.V., Golik, N.Y., Chernenok, I.N. et al. 4-Hydroxy-2-quinolones. 220*. Bromination of ethyl 7-hydroxy-5-oxo-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-6-carboxylate. Chem Heterocycl Comp 48, 1665–1669 (2013). https://doi.org/10.1007/s10593-013-1190-8
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DOI: https://doi.org/10.1007/s10593-013-1190-8