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Chemistry of Heterocyclic Compounds

, Volume 48, Issue 2, pp 320–326 | Cite as

4-hydroxy-2-quinolones. 202*. Synthesis, chemical and biological properties of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkylamides

  • I. V. UkrainetsEmail author
  • O. V. Bevz
  • E. V. Mospanova
  • L. V. Savchenkova
  • S. I. Yankovich
Article

In continuation of the search for potential analgesics amongst 4-hydroxyquinol-2-one derivatives we have proposed and carried out a preparative method of synthesis of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkylamides. It has been shown that bromination of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid allylamide using an equivalent of molecular bromine occurs with a conventional addition of the halogen to the allyl double bond and not with halocyclization. The results of the study of the analgesic properties of the compounds prepared are presented.

Keywords

4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides amidation analgesic activity bromination 

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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • I. V. Ukrainets
    • 1
    Email author
  • O. V. Bevz
    • 1
  • E. V. Mospanova
    • 2
  • L. V. Savchenkova
    • 3
  • S. I. Yankovich
    • 3
  1. 1.National University of PharmacyKharkivUkraine
  2. 2.Institute of Chemical Technology East Ukraine Volodymyr Dahl National UniversityRubezhnoeUkraine
  3. 3.Lugansk State Medicinal UniversityLuganskUkraine

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