In continuation of the search for potential analgesics amongst 4-hydroxyquinol-2-one derivatives we have proposed and carried out a preparative method of synthesis of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkylamides. It has been shown that bromination of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid allylamide using an equivalent of molecular bromine occurs with a conventional addition of the halogen to the allyl double bond and not with halocyclization. The results of the study of the analgesic properties of the compounds prepared are presented.
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*For Communication 201, see [1].
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 339-346, February, 2012.
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Ukrainets, I.V., Bevz, O.V., Mospanova, E.V. et al. 4-hydroxy-2-quinolones. 202*. Synthesis, chemical and biological properties of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkylamides. Chem Heterocycl Comp 48, 320–326 (2012). https://doi.org/10.1007/s10593-012-0992-4
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DOI: https://doi.org/10.1007/s10593-012-0992-4