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Modification of the Pictet–Spengler reaction in the synthesis of fused 2,3-benzodiazocines

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Chemistry of Heterocyclic Compounds Aims and scope

A new strategy for the synthesis of the eight-membered heterocyclic skeleton of tetrahydro-quinazolino[3,2-c][2,3]benzodiazocin-15-ones, based on the Pictet–Spengler reaction of 3-amino-2-[2-(3,4-dimethoxyphenyl)ethyl]quinazolin-4(3H)-one with carbonyl compounds in acidic media, is proposed.

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Authors and Affiliations

  1. L. M. Litvinenko Institute of Physical-Organic Chemistry and Coal Chemistry, National Academy of Sciences of Ukraine, 70 R. Luxemburg St., Donetsk, 83114, Ukraine

    A. S. Tolkunov, S. V. Tolkunov & S. L. Bogza

  2. Research Branch for the Chemistry of Functional Materials, Institute for Single Crystals of the National Academy of Sciences of Ukraine, 60 Lenin Ave., Kharkiv, 61001, Ukraine

    V. N. Baumer, G. V. Palamarchuk & O. V. Shishkin

  3. V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv, 61077, Ukraine

    O. V. Shishkin

  4. A. V. Bogatsky Physico-Chemical Institute, National Academy of Sciences of Ukraine, 86 Lustdorfskaya Road, Odessa, 65080, Ukraine

    A.V. Mazepa

Authors
  1. A. S. Tolkunov
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  2. V. N. Baumer
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  3. G. V. Palamarchuk
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  4. O. V. Shishkin
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  5. A.V. Mazepa
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  6. S. V. Tolkunov
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  7. S. L. Bogza
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Corresponding author

Correspondence to A. S. Tolkunov.

Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1223–1231, August, 2011.

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Tolkunov, A.S., Baumer, V.N., Palamarchuk, G.V. et al. Modification of the Pictet–Spengler reaction in the synthesis of fused 2,3-benzodiazocines. Chem Heterocycl Comp 47, 1006–1013 (2011). https://doi.org/10.1007/s10593-011-0867-0

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  • DOI: https://doi.org/10.1007/s10593-011-0867-0

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