The alkylation of 3-(2-hydroxyethyl)-1H,3H-quinazoline-2,4-dione and subsequent bromination of its 1-allyl derivative have been studied. The data obtained has been compared with the results of similar studies on a series of other, related compounds. A rule has been formulated which allows a prediction of 1-allyl-substituted 2-oxo azaheterocycles bromination route based upon the way in which their initial alkylation by allyl bromide in the system DMSO–K2CO3 occurs.
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For Communication 195, see [1].
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 885–891, June, 2011.
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Ukrainets, I.V., Mospanova, E.V., Turov, A.V. et al. 4-hydroxy-2-quinolones 196. synthesis and bromination of 1-allyl-3-(2-hydroxyethyl)-1h,3h-quinazoline-2,4-dione. Chem Heterocycl Comp 47, 731–736 (2011). https://doi.org/10.1007/s10593-011-0827-8
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DOI: https://doi.org/10.1007/s10593-011-0827-8