Some 4-N-R-2-Oxo-1,2-dihydroquinoline-3-carboxylic acids and their derivatives were synthesized as close structural analogs of the highly-active analgesic 4-benzylamino-2-oxo-1,2-dihydroquinoline-carboxylic acid. Pharmacological testing showed that manifestation of an analgesic effect depends on the presence of a carboxylic group and benzyl fragment in these molecules.
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* Communication 191, see [1].
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1690–1701, November, 2010.
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Ukrainets, I.V., Mospanova, E.V., Davidenko, A.A. et al. 4-Hydro-2-quinolones. 192.* relationship of xy structure and analgesic activity of 4-amino-2-oxo-1,2-dihydroquinoline-3-carboxylic acids and their derivatives. Chem Heterocycl Comp 46, 1371–1379 (2011). https://doi.org/10.1007/s10593-011-0674-7
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DOI: https://doi.org/10.1007/s10593-011-0674-7