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4-Hydro-2-quinolones. 192.* relationship of xy structure and analgesic activity of 4-amino-2-oxo-1,2-dihydroquinoline-3-carboxylic acids and their derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

Some 4-N-R-2-Oxo-1,2-dihydroquinoline-3-carboxylic acids and their derivatives were synthesized as close structural analogs of the highly-active analgesic 4-benzylamino-2-oxo-1,2-dihydroquinoline-carboxylic acid. Pharmacological testing showed that manifestation of an analgesic effect depends on the presence of a carboxylic group and benzyl fragment in these molecules.

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Authors and Affiliations

  1. National University of Pharmacy, Kharkiv, 61002, Ukraine

    I. V. Ukrainets

  2. Institute of Chemical Technology, Vladimir Dal’ Eastern Ukrainian National University, Rubizhne, 93003, Ukraine

    E. V. Mospanova

  3. N. I. Pirogov Vinnitsa National Medical University, Vinnitsa, 21018, Ukraine

    A. A. Davidenko

  4. Institute for Single Crystals, National Academy of Sciences of Ukraine, Kharkiv, 61001, Ukraine

    S. V. Shishkina

Authors
  1. I. V. Ukrainets
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  2. E. V. Mospanova
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  3. A. A. Davidenko
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  4. S. V. Shishkina
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Corresponding author

Correspondence to I. V. Ukrainets.

Additional information

* Communication 191, see [1].

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1690–1701, November, 2010.

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Ukrainets, I.V., Mospanova, E.V., Davidenko, A.A. et al. 4-Hydro-2-quinolones. 192.* relationship of xy structure and analgesic activity of 4-amino-2-oxo-1,2-dihydroquinoline-3-carboxylic acids and their derivatives. Chem Heterocycl Comp 46, 1371–1379 (2011). https://doi.org/10.1007/s10593-011-0674-7

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  • DOI: https://doi.org/10.1007/s10593-011-0674-7

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