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Cell and Tissue Banking

, Volume 13, Issue 4, pp 547–563 | Cite as

Physical examination of potential tissue donors: results of a risk management procedure to identify the critical elements of the physical examination

  • Marja J. van WijkEmail author
  • Caroline van Geyt
  • Audrey B. H. Laven
  • Hilde Beele
  • Arlinke G. Bokhorst
Article

Abstract

To identify critical elements of physical examination (PE) of potential tissue donors that could help to improve the safety of tissue transplantation. Physical signs were identified that can indicate the presence of a contraindication mentioned in EU Directive 2006/17/EC and that can theoretically be detected at PE. A risk assessment was designed, according to the Failure Mode and Effects Analysis model. Signs were scored on several aspects, taking into account various control measures, either required in the EU Directive or additional non-required measures. 106 signs associated with general and tissue-specific contraindications were identified. Signs of advanced infection with HIV, hepatitis B/C and syphilis (n = 13, 12.3%) can be omitted, since these contraindications will be detected by the required serological testing. With the required control measures, risk priorities are unacceptably “high” for 17.3% of the signs. For 64.5% of the signs, additional control measures are possible, which result in acceptable risk priorities for all signs. This risk management procedure identified the minimal necessary content of PE in potential tissue donors. Furthermore, risks associated with tissue donation were elucidated and possible risk control measures were identified as well as their impact on the safety of tissue transplantation.

Keywords

Risk management Tissue transplantation Safety Physical examination Physical signs FMEA model 

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Marja J. van Wijk
    • 1
    Email author
  • Caroline van Geyt
    • 2
  • Audrey B. H. Laven
    • 1
  • Hilde Beele
    • 2
  • Arlinke G. Bokhorst
    • 1
  1. 1.BISLIFE FoundationLeidenThe Netherlands
  2. 2.Tissue BankGhent University HospitalGhentBelgium

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