Amino Acids

, Volume 41, Issue 4, pp 773–780 | Cite as

S100A6 binding protein and Siah-1 interacting protein (CacyBP/SIP): spotlight on properties and cellular function

  • Gabriela Schneider
  • Anna FilipekEmail author
Review Article


The CacyBP/SIP protein (S100A6 binding protein and Siah-1 interacting protein) was originally discovered in Ehrlich ascites tumor cells as a S100A6 (calcyclin) target (Filipek and Wojda in Biochem J 320:585–587, 1996; Filipek and Kuźnicki in J Neurochem 70(5):1793–1798, 1998) and later on as a Siah-1 interacting protein (Matsuzawa and Reed in Mol Cell 7(5):915–926, 2001). CacyBP/SIP binds several target proteins such as some calcium binding proteins of the S100 family (Filipek et al. in J Biol Chem 277(32):28848–28852, 2002), Skp1 (Matsuzawa and Reed in Mol Cell 7(5):915–926, 2001), tubulin (Schneider et al. in Biochim Biophys Acta 1773(11):1628–1636, 2007) and ERK1/2 (Kilanczyk et al. in Biochem Biophys Res Commun 380:54–59, 2009). Studies concerning distribution of CacyBP/SIP show that it is present in various tissues and that a particularly high level of CacyBP/SIP is observed in brain (Jastrzebska et al. in J Histochem Cytochem 48(9):1195–1202, 2000). Regarding the function of CacyBP/SIP, there are some reports suggesting its role in cellular processes such as ubiquitination, proliferation, differentiation, tumorigenesis, cytoskeletal rearrangement or regulation of transcription. This review describes the properties of CacyBP/SIP and summarizes all findings concerning its cellular function.


CacyBP/SIP S100A6 (calcyclin) Ubiquitination Proliferation Differentiation Tumorigenesis 



We thank Dr. W. Lesniak for helpful discussion and critical reading of the manuscript. This work was supported by a grant to A. Filipek (2 P04A 01030) from the Ministry of Science and Higher Education of Poland and by statutory funds from the Nencki Institute of Experimental Biology.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Nencki Institute of Experimental BiologyWarsawPoland

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