Skip to main content
SpringerLink
Log in

Different postprandial acute response in healthy subjects to three strawberry jams varying in carbohydrate and antioxidant content: a randomized, crossover trial

  • Original Contribution
  • Published:
European Journal of Nutrition Aims and scope Submit manuscript

Abstract

Purpose

Dietary food composition influences postprandial glucose homeostasis. Thus, the objective was to investigate the effects of an acute intake of three different types of strawberry jam, differing in carbohydrate and antioxidants content, on postprandial glucose metabolism, lipid profile, antioxidant status, and satiety.

Methods

Sixteen healthy adults participated in a randomized, crossover, double-blind study with three arms, receiving 60 g of three different strawberry jams. Blood samples were collected at fasting and at 30, 60, 90, and 120 min after its intake. Blood analyses were performed with validated procedures and satiety was estimated with visual analogue scale (VAS).

Results

Blood glucose concentrations were maintained at normal values and without peaks within the 2 h after consumption of low-sugar jams. However, blood glucose and insulin were significantly higher at 30 and 60 min after high-sugar (HS) jam intake versus both low-sugar jams. Furthermore, HS jam produced more satisfaction at short time, but decreased as soon as blood glucose concentration began to decrease. Moreover, HS ingestion produced lower free fatty acid levels (p < 0.05) throughout the trial with respect both the low-sugar jams. However, no additional benefits on oxidative status (malondialdehyde, glutathione peroxidase, total antioxidant capacity, and uric acid), glucose, lipid, and satiety variables were observed due to the inclusion of an antioxidant to low-sugar jam.

Conclusions

This study reinforces the idea that products without added sugars are appropriate for the management of glycemic alterations and provides further insight into the effect of natural antioxidants as a functional ingredient on oxidative status and related metabolic disturbances. Registered at www.clinicaltrials.gov as NCT01684332.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

Abbreviations

FFA:

Free fatty acids

GI:

Glycemic index

GPx:

Glutathione peroxidase

HDL-c:

High-density lipoprotein-cholesterol

HOMA-IR:

Homeostasis model assessment-estimated insulin resistance

HS:

High-sugar jam

LDL-c:

Low-density lipoprotein-cholesterol

LS:

Low-sugar jam

LSA:

Low-sugar jam including antioxidant extract

MDA:

Malondialdehyde

TAC:

Total antioxidant capacity

TG:

Triglycerides

VAS:

Visual analogue scale

References

  1. Henry CJ, Ranawana V (2012) Sugar: a problem of developed countries. Nature 482(7386):471. doi:10.1038/482471a

    Article  CAS  Google Scholar 

  2. Perez-Matute P, Zulet MA, Martinez JA (2009) Reactive species and diabetes: counteracting oxidative stress to improve health. Curr Opin Pharmacol 9(6):771–779

    Article  CAS  Google Scholar 

  3. Bondia-Pons I, Ryan L, Martinez JA (2012) Oxidative stress and inflammation interactions in human obesity. J Physiol Biochem 68(4):701–711

    Google Scholar 

  4. Burton-Freeman B (2010) Postprandial metabolic events and fruit-derived phenolics: a review of the science. Br J Nutr 104(Suppl 3):S1–S14

    Article  CAS  Google Scholar 

  5. Barbosa KB, Bressan J, Zulet MA, Martinez Hernandez JA (2008) Influence of dietary intake on plasma biomarkers of oxidative stress in humans. An Sist Sanit Navar 31(3):259–280

    CAS  Google Scholar 

  6. Puchau B, Zulet MA, de Echavarri AG, Hermsdorff HH, Martinez JA (2010) Dietary total antioxidant capacity is negatively associated with some metabolic syndrome features in healthy young adults. Nutrition 26(5):534–541

    Article  CAS  Google Scholar 

  7. Abete I, Goyenechea E, Zulet MA, Martinez JA (2011) Obesity and metabolic syndrome: potential benefit from specific nutritional components. Nutr Metab Cardiovasc Dis 21(Suppl 2):B1–B15

    Article  CAS  Google Scholar 

  8. Laville M, Nazare JA (2009) Diabetes, insulin resistance and sugars. Obes Rev 10(Suppl 1):24–33

    Article  CAS  Google Scholar 

  9. Crujeiras AB, Parra MD, Rodriguez MC, Martinez de Morentin BE, Martinez JA (2006) A role for fruit content in energy-restricted diets in improving antioxidant status in obese women during weight loss. Nutrition 22(6):593–599

    Article  CAS  Google Scholar 

  10. Riso P, Klimis-Zacas D, Del Bo C, Martini D, Campolo J, Vendrame S, Moller P, Loft S, De Maria R, Porrini M (2012) Effect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factors. Eur J Nutr. doi:10.1007/s00394-012-0402-9

    Google Scholar 

  11. Yuan L, Meng L, Ma W, Xiao Z, Zhu X, Feng JF, Yu H, Xiao R (2011) Impact of apple and grape juice consumption on the antioxidant status in healthy subjects. Int J Food Sci Nutr 62(8):844–850

    Article  CAS  Google Scholar 

  12. Lynn A, Hamadeh H, Leung WC, Russell JM, Barker ME (2012) Effects of pomegranate juice supplementation on pulse wave velocity and blood pressure in healthy young and middle-aged men and women. Plant Foods Hum Nutr 67(3):309–314

    Google Scholar 

  13. Abete I, Parra D, Martinez JA (2008) Energy-restricted diets based on a distinct food selection affecting the glycemic index induce different weight loss and oxidative response. Clin Nutr 27(4):545–551

    Article  CAS  Google Scholar 

  14. Wheeler ML, Pi-Sunyer FX (2008) Carbohydrate issues: type and amount. J Am Diet Assoc 108(4 Suppl 1):S34–S39

    Article  CAS  Google Scholar 

  15. Giampieri F, Tulipani S, Alvarez-Suarez JM, Quiles JL, Mezzetti B, Battino M (2012) The strawberry: composition, nutritional quality, and impact on human health. Nutrition 28(1):9–19

    CAS  Google Scholar 

  16. Kurotobi T, Fukuhara K, Inage H, Kimura S (2010) Glycemic index and postprandial blood glucose response to Japanese strawberry jam in normal adults. J Nutr Sci Vitaminol (Tokyo) 56(3):198–202

    Article  CAS  Google Scholar 

  17. Flint A, Raben A, Blundell JE, Astrup A (2000) Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord 24(1):38–48

    Article  CAS  Google Scholar 

  18. Whitworth JA, Chalmers J (2004) World health organisation-international society of hypertension (WHO/ISH) hypertension guidelines. Clin Exp Hypertens 26(7–8):747–752

    Article  Google Scholar 

  19. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7):412–419

    Article  CAS  Google Scholar 

  20. Crujeiras AB, Parra D, Abete I, Martinez JA (2007) A hypocaloric diet enriched in legumes specifically mitigates lipid peroxidation in obese subjects. Free Radic Res 41(4):498–506

    Article  CAS  Google Scholar 

  21. Murase T, Yokoi Y, Misawa K, Ominami H, Suzuki Y, Shibuya Y, Hase T (2012) Coffee polyphenols modulate whole-body substrate oxidation and suppress postprandial hyperglycaemia, hyperinsulinaemia and hyperlipidaemia. Br J Nutr 107(12):1757–1765

    Article  CAS  Google Scholar 

  22. Aller EE, Abete I, Astrup A, Martinez JA, van Baak MA (2011) Starches, sugars and obesity. Nutrients 3(3):341–369

    Article  CAS  Google Scholar 

  23. Brand-Miller J, Buyken AE (2012) The glycemic index issue. Curr Opin Lipidol 23(1):62–67

    Article  CAS  Google Scholar 

  24. Ulmius M, Johansson A, Onning G (2009) The influence of dietary fibre source and gender on the postprandial glucose and lipid response in healthy subjects. Eur J Nutr 48(7):395–402

    Article  CAS  Google Scholar 

  25. Hanhineva K, Torronen R, Bondia-Pons I, Pekkinen J, Kolehmainen M, Mykkanen H, Poutanen K (2010) Impact of dietary polyphenols on carbohydrate metabolism. Int J Mol Sci 11(4):1365–1402

    Article  CAS  Google Scholar 

  26. Hermsdorff HH, Barbosa KB, Volp AC, Puchau B, Bressan J, Zulet MA, Martinez JA (2012) Vitamin C and fibre consumption from fruits and vegetables improves oxidative stress markers in healthy young adults. Br J Nutr 107(8):1119–1127

    Article  CAS  Google Scholar 

  27. Peters HP, Ravestein P, van der Hijden HT, Boers HM, Mela DJ (2011) Effect of carbohydrate digestibility on appetite and its relationship to postprandial blood glucose and insulin levels. Eur J Clin Nutr 65(1):47–54

    Article  CAS  Google Scholar 

  28. Ferrannini E, Camastra S, Coppack SW, Fliser D, Golay A, Mitrakou A (1997) Insulin action and non-esterified fatty acids. The European group for the study of insulin resistance (EGIR). Proc Nutr Soc 56(2):753–761

    Article  CAS  Google Scholar 

  29. Ferrannini E, Galvan AQ, Gastaldelli A, Camastra S, Sironi AM, Toschi E, Baldi S, Frascerra S, Monzani F, Antonelli A, Nannipieri M, Mari A, Seghieri G, Natali A (1999) Insulin: new roles for an ancient hormone. Eur J Clin Invest 29(10):842–852

    Article  CAS  Google Scholar 

  30. Ueda M, Hayashibara K, Ashida H (2013) Propolis extract promotes translocation of glucose transporter 4 and glucose uptake through both PI3 K- and AMPK-dependent pathways in skeletal muscle. BioFactors. doi:10.1002/biof.1085

    Google Scholar 

  31. Kwon O, Eck P, Chen S, Corpe CP, Lee JH, Kruhlak M, Levine M (2007) Inhibition of the intestinal glucose transporter GLUT2 by flavonoids. FASEB J 21(2):366–377

    Article  CAS  Google Scholar 

  32. Clegg ME, Pratt M, Meade CM, Henry CJ (2011) The addition of raspberries and blueberries to a starch-based food does not alter the glycaemic response. Br J Nutr 106(3):335–338

    Article  CAS  Google Scholar 

  33. Savikin K, Zdunic G, Jankovic T, Tasic S, Menkovic N, Stevic T, Dordevic B (2009) Phenolic content and radical scavenging capacity of berries and related jams from certificated area in Serbia. Plant Foods Hum Nutr 64(3):212–217

    Article  CAS  Google Scholar 

  34. Poiana MA, Alexa E, Mateescu C (2012) Tracking antioxidant properties and color changes in low-sugar bilberry jam as effect of processing, storage and pectin concentration. Chem Cent J 6:4. doi:10.1186/1752-153X-6-4

    Article  CAS  Google Scholar 

  35. Mazzone T, Foster D, Chait A (1984) In vivo stimulation of low-density lipoprotein degradation by insulin. Diabetes 33(4):333–338

    Article  CAS  Google Scholar 

  36. Quinones-Galvan A, Sironi AM, Baldi S, Galetta F, Garbin U, Fratta-Pasini A, Cominacini L, Ferrannini E (1999) Evidence that acute insulin administration enhances LDL cholesterol susceptibility to oxidation in healthy humans. Arterioscler Thromb Vasc Biol 19(12):2928–2932

    Article  CAS  Google Scholar 

  37. Paterson EGM, Niwat C, George TW, Parr L, Waroonphan S, Lovegrove JA (2006) Supplementation with fruit and vegetable soups and beverages increases plasma carotenoid concentrations but does not alter markers of oxidative stress or cardiovascular risk factors. J Nutr 136(11):7

    Google Scholar 

  38. Navas-Carretero S, Cuervo M, Abete I, Zulet MA, Martinez JA (2011) Frequent consumption of selenium-enriched chicken meat by adults causes weight loss and maintains their antioxidant status. Biol Trace Elem Res 143(1):8–19

    Article  CAS  Google Scholar 

  39. van Mierlo LA, Zock PL, van der Knaap HC, Draijer R (2010) Grape polyphenols do not affect vascular function in healthy men. J Nutr 140(10):1769–1773

    Article  Google Scholar 

  40. Linderborg KM, Jarvinen R, Lehtonen HM, Viitanen M, Kallio HP (2012) The fiber and/or polyphenols present in lingonberries null the glycemic effect of the sugars present in the berries when consumed together with added glucose in healthy human volunteers. Nutr Res 32(7):471–478

    Article  CAS  Google Scholar 

  41. Lotito SBFB (2004) Relevance of apple polyphenols as antioxidants in human plasma: contrasting in vitro and in vivo effects. Free Radic Biol Med 36(2):11

    Google Scholar 

  42. Mayer J (1953) Glucostatic mechanism of regulation of food intake. N Engl J Med 249(1):13–16

    CAS  Google Scholar 

  43. Campfield LA, Smith FJ (1990) Transient declines in blood glucose signal meal initiation. Int J Obes 14(Suppl 3):15–31

    Google Scholar 

  44. Keogh J, Atkinson F, Eisenhauer B, Inamdar A, Brand-Miller J (2011) Food intake, postprandial glucose, insulin and subjective satiety responses to three different bread-based test meals. Appetite 57(3):707–710

    Article  Google Scholar 

  45. Woodend DM, Anderson GH (2001) Effect of sucrose and safflower oil preloads on short term appetite and food intake of young men. Appetite 37(3):185–195

    Article  CAS  Google Scholar 

  46. Bornet FR, Jardy-Gennetier AE, Jacquet N, Stowell J (2007) Glycaemic response to foods: impact on satiety and long-term weight regulation. Appetite 49(3):535–553

    Article  CAS  Google Scholar 

  47. Griffioen-Roose S, Hogenkamp PS, Mars M, Finlayson G, de Graaf C (2012) Taste of a 24-h diet and its effect on subsequent food preferences and satiety. Appetite 59(1):1–8

    Article  Google Scholar 

Download references

Acknowledgments

The authors gratefully acknowledge the financial support of the CDTI within CENIT Program (Tools to investigate and create new methodologies and technologies for the prevention of food chronic diseases–HIGEA) as well as the University of Navarra LE/97 and CIBERobn (Physiopathology of Obesity and Nutrition, Carlos III Health Research Institute). Thanks are given to the physician (Martínez de Morentin, BE), the nurse (Pérez, S), and the technician (Ciaurriz, V). Also, the authors wish to thank Helios S.A (Valladolid, Spain) for supplying jam products and the National Center for Food Safety and Technology (CNTA, Navarra, Spain) for analyzing the composition of the jams. Idoia Ibero-Baraibar appreciates the scholarship of Navarra University (ADA).

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Nutrition, Food Science and Physiology, University of Navarra, C/Irunlarrea 1, 31008, Pamplona, Navarra, Spain

    Idoia Ibero-Baraibar, Marta Cuervo, Santiago Navas-Carretero, Itziar Abete, M. Angeles Zulet & J. Alfredo Martinez

  2. Physiopathology of Obesity and Nutrition, CIBERobn. Carlos III Health Research Institute, Madrid, Spain

    Marta Cuervo, Santiago Navas-Carretero, M. Angeles Zulet & J. Alfredo Martinez

Authors
  1. Idoia Ibero-Baraibar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marta Cuervo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Santiago Navas-Carretero
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Itziar Abete
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Angeles Zulet
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. Alfredo Martinez
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. Angeles Zulet.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ibero-Baraibar, I., Cuervo, M., Navas-Carretero, S. et al. Different postprandial acute response in healthy subjects to three strawberry jams varying in carbohydrate and antioxidant content: a randomized, crossover trial. Eur J Nutr 53, 201–210 (2014). https://doi.org/10.1007/s00394-013-0517-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00394-013-0517-7

Keywords

Search

Navigation