The relationship between high-fat dairy consumption and obesity, cardiovascular, and metabolic disease

Abstract

Purpose

To comprehensively review the data on the relationship between the consumption of dairy fat and high-fat dairy foods, obesity, and cardiometabolic disease.

Methods

We have conducted a systematic literature review of observational studies on the relationship between dairy fat and high-fat dairy foods, obesity, and cardiometabolic disease. We have integrated these findings with data from controlled studies showing effects of several minor dairy fatty acids on adiposity and cardiometabolic risk factors, and data on how bovine feeding practices influence the composition of dairy fat.

Results

In 11 of 16 studies, high-fat dairy intake was inversely associated with measures of adiposity. Studies examining the relationship between high-fat dairy consumption and metabolic health reported either an inverse or no association. Studies investigating the connection between high-fat dairy intake and diabetes or cardiovascular disease incidence were inconsistent. We discuss factors that may have contributed to the variability between studies, including differences in (1) the potential for residual confounding; (2) the types of high-fat dairy foods consumed; and (3) bovine feeding practices (pasture- vs. grain-based) known to influence the composition of dairy fat.

Conclusions

The observational evidence does not support the hypothesis that dairy fat or high-fat dairy foods contribute to obesity or cardiometabolic risk, and suggests that high-fat dairy consumption within typical dietary patterns is inversely associated with obesity risk. Although not conclusive, these findings may provide a rationale for future research into the bioactive properties of dairy fat and the impact of bovine feeding practices on the health effects of dairy fat.

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References

  1. 1.

    United States Department of Agriculture Department of Health and Human Services (2010) Dietary Guidelines for Americans

  2. 2.

    Gidding SS, Lichtenstein AH, Faith MS, Karpyn A, Mennella JA, Popkin B, Rowe J, Van Horn L, Whitsel L (2009) Implementing American Heart Association pediatric and adult nutrition guidelines: a scientific statement from the American heart association nutrition committee of the council on nutrition, physical activity and metabolism, council on cardiovascular disease in the young, council on arteriosclerosis, thrombosis and vascular biology, council on cardiovascular nursing, council on epidemiology and prevention, and council for high blood pressure research. Circulation 119:1161–1175

    Article  Google Scholar 

  3. 3.

    Siri-Tarino PW, Sun Q, Hu FB, Krauss RM (2010) Saturated fatty acids and risk of coronary heart disease: modulation by replacement nutrients. Curr Atheroscler Rep 12:384–390

    Article  CAS  Google Scholar 

  4. 4.

    Kratz M (2005) Dietary cholesterol, atherosclerosis and coronary heart disease. Handb Exp Pharmacol 170:195–213

    Article  CAS  Google Scholar 

  5. 5.

    Rolls BJ (2009) The relationship between dietary energy density and energy intake. Physiol Behav 97:609–615

    Article  CAS  Google Scholar 

  6. 6.

    United States Department of Agriculture Economic Research Service (2011) Food Availability (Per Capita) Data System. http://www.ers.usda.gov/Data/FoodConsumption/FoodGuideSpreadsheets.htm. Accessed on August 20

  7. 7.

    Hooper L, Summerbell CD, Thompson R, Sills D, Roberts FG, Moore H, Davey Smith G (2011) Reduced or modified dietary fat for preventing cardiovascular disease (Review). Cochrane Database Syst Rev 7:CD002137

  8. 8.

    Ramsden CE, Hibbeln JR, Majchrzak SF, Davis JM (2010) n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials. Br J Nutr 104:1586–1600

    Article  CAS  Google Scholar 

  9. 9.

    Elwood PC, Pickering JE, Givens DI, Gallacher JE (2010) The consumption of milk and dairy foods and the incidence of vascular disease and diabetes: an overview of the evidence. Lipids 45:925–939

    Article  CAS  Google Scholar 

  10. 10.

    Dougkas A, Reynolds CK, Givens ID, Elwood PC, Minihane AM (2011) Associations between dairy consumption and body weight: a review of the evidence and underlying mechanisms. Nutr Res Rev 24:72–95

    Article  Google Scholar 

  11. 11.

    Salvini S, Hunter DJ, Sampson L, Stampfer MJ, Colditz GA, Rosner B, Willett WC (1989) Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption. Int J Epidemiol 18:858–867

    Article  CAS  Google Scholar 

  12. 12.

    Wu Z, Palmquist DL (1991) Synthesis and biohydrogenation of fatty acids by ruminal microorganisms in vitro. J Dairy Res 74:3035–3046

    Article  CAS  Google Scholar 

  13. 13.

    Wolk A, Vessby B, Ljung H, Barrefors P (1998) Evaluation of a biological marker of dairy fat intake. Am J Clin Nutr 68:291–295

    CAS  Google Scholar 

  14. 14.

    Smedman AE, Gustafsson IB, Berglund LG, Vessby BO (1999) Pentadecanoic acid in serum as a marker for intake of milk fat: relations between intake of milk fat and metabolic risk factors. Am J Clin Nutr 69:22–29

    CAS  Google Scholar 

  15. 15.

    Micha R, King IB, Lemaitre RN, Rimm EB, Sacks F, Song X, Siscovick DS, Mozaffarian D (2010) Food sources of individual plasma phospholipid trans fatty acid isomers: the cardiovascular health study. Am J Clin Nutr 91:883–893

    Article  CAS  Google Scholar 

  16. 16.

    Koger TJ, Wulf DM, Weaver AD, Wright CL, Tjardes KE, Mateo KS, Engle TE, Maddock RJ, Smart AJ (2010) Influence of feeding various quantities of wet and dry distillers grains to finishing steers on carcass characteristics, meat quality, retail-case life of ground beef, and fatty acid profile of longissimus muscle. J Animal Sci 88:3399–3408

    Article  CAS  Google Scholar 

  17. 17.

    Ozogul Y, Ozogul F, Ci cek E, Polat A, Kuley E (2009) Fat content and fatty acid compositions of 34 marine water fish species from the Mediterranean Sea. Int J Food Sci Nutr 60:464–475

    Article  CAS  Google Scholar 

  18. 18.

    Hodge AM, English DR, O’Dea K, Sinclair AJ, Makrides M, Gibson RA, Giles GG (2007) Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: interpreting the role of linoleic acid. Am J Clin Nutr 86:189–197

    CAS  Google Scholar 

  19. 19.

    Pereira MA, Jacobs DR Jr, Van Horn L, Slattery ML, Kartashov AI, Ludwig DS (2002) Dairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA Study. JAMA 287:2081–2089

    Article  Google Scholar 

  20. 20.

    Rosell M, Johansson G, Berglund L, Vessby B, de Faire U, Hellenius ML (2004) Associations between the intake of dairy fat and calcium and abdominal obesity. Int J Obes 28:1427–1434

    Article  CAS  Google Scholar 

  21. 21.

    Warensjo E, Jansson JH, Berglund L, Boman K, Ahren B, Weinehall L, Lindahl B, Hallmans G, Vessby B (2004) Estimated intake of milk fat is negatively associated with cardiovascular risk factors and does not increase the risk of a first acute myocardial infarction. A prospective case-control study. Br J Nutr 91:635–642

    Article  Google Scholar 

  22. 22.

    Barba G, Troiano E, Russo P, Venezia A, Siani A (2005) Inverse association between body mass and frequency of milk consumption in children. Br J Nutr 93:15–19

    Article  CAS  Google Scholar 

  23. 23.

    Rajpathak SN, Rimm EB, Rosner B, Willett WC, Hu FB (2006) Calcium and dairy intakes in relation to long-term weight gain in US men. Am J Clin Nutr 83:559–566

    CAS  Google Scholar 

  24. 24.

    Rosell M, Hakansson NN, Wolk A (2006) Association between dairy food consumption and weight change over 9 y in 19,352 perimenopausal women. Am J Clin Nutr 84:1481–1488

    CAS  Google Scholar 

  25. 25.

    Snijder MB, van der Heijden AA, van Dam RM, Stehouwer CD, Hiddink GJ, Nijpels G, Heine RJ, Bouter LM, Dekker JM (2007) Is higher dairy consumption associated with lower body weight and fewer metabolic disturbances? The Hoorn study. Am J Clin Nutr 85:989–995

    CAS  Google Scholar 

  26. 26.

    Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS (2010) Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in U.S. adults: a cohort study. Ann Int Med 153:790–799

    Google Scholar 

  27. 27.

    Warensjo E, Jansson JH, Cederholm T, Boman K, Eliasson M, Hallmans G, Johansson I, Sjogren P (2010) Biomarkers of milk fat and the risk of myocardial infarction in men and women: a prospective, matched case-control study. Am J Clin Nutr 92:194–202

    Article  Google Scholar 

  28. 28.

    te Velde SJ, Snijder MB, van Dijk AE, Brug J, Koppes LL, van Mechelen W, Twisk JW (2011) Dairy intake from adolescence into adulthood is not associated with being overweight and metabolic syndrome in adulthood: the Amsterdam growth and health longitudinal study. J Hum Nutr Diet 24:233–244

    Article  Google Scholar 

  29. 29.

    Noel SE, Ness AR, Northstone K, Emmett P, Newby PK (2011) Milk intakes are not associated with percent body fat in children from ages 10–13 years. J Nutr 141:2035–2041

    Article  CAS  Google Scholar 

  30. 30.

    Berkey CS, Rockett HR, Willett WC, Colditz GA (2005) Milk, dairy fat, dietary calcium, and weight gain: a longitudinal study of adolescents. Arch Pediatr Adolesc Med 159:543–550

    Article  Google Scholar 

  31. 31.

    Beydoun MA, Gary TL, Caballero BH, Lawrence RS, Cheskin LJ, Wang Y (2008) Ethnic differences in dairy and related nutrient consumption among US adults and their association with obesity, central obesity, and the metabolic syndrome. Am J Clin Nutr 87:1914–1925

    CAS  Google Scholar 

  32. 32.

    Duffey KJ, Gordon-Larsen P, Steffen LM, Jacobs DR Jr, Popkin BM (2010) Drinking caloric beverages increases the risk of adverse cardiometabolic outcomes in the coronary artery risk development in young adults (CARDIA) Study. Am J Clin Nutr 92:954–959

    Article  CAS  Google Scholar 

  33. 33.

    Phillips SM, Bandini LG, Cyr H, Colclough-Douglas S, Naumova E, Must A (2003) Dairy food consumption and body weight and fatness studied longitudinally over the adolescent period. Int J Obes 27:1106–1113

    Article  CAS  Google Scholar 

  34. 34.

    Liu S, Choi HK, Ford E, Song Y, Klevak A, Buring JE, Manson JE (2006) A prospective study of dairy intake and the risk of type 2 diabetes in women. Diabetes Care 29:1579–1584

    Article  Google Scholar 

  35. 35.

    Margolis KL, Wei F, de Boer IH, Howard BV, Liu S, Manson JE, Mossavar-Rahmani Y, Phillips LS, Shikany JM, Tinker LF (2011) A diet high in low-fat dairy products lowers diabetes risk in postmenopausal women. J Nutr 141:1969–1974

    Article  CAS  Google Scholar 

  36. 36.

    Sauer J, Nehring RF, Gillespie JM, Morrison-Paul C, Blayney D, Hallahan C, Latruffe L (2010) Determining the competitive edge: diversified dairy production systems in the United States and the European Union. In Agricultural & Applied Economics Association (AAEA) 2010 Annual Meeting. Denver, CO

  37. 37.

    Binckman D (2000) The regulation of rBST: The European case. J Agrobiotech Management Econ 3:Article 15

    Google Scholar 

  38. 38.

    New Zealand Ministry of Agriculture and Forestry (2011) http://www.maf.govt.nz/agriculture/pastoral. Accessed on November 29

  39. 39.

    Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, Hofman A, Witteman JC (2004) Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr 134:3100–3105

    CAS  Google Scholar 

  40. 40.

    Centers for Disease Control and Prevention (2011) National Diabetes Fact Sheet. http://www.cdc.gov/diabetes/pubs/pdf/ndfs_2011.pdf. Accessed on August 24

  41. 41.

    Iggman D, Arnlov J, Vessby B, Cederholm T, Sjogren P, Riserus U (2010) Adipose tissue fatty acids and insulin sensitivity in elderly men. Diabetologia 53:850–857

    Article  CAS  Google Scholar 

  42. 42.

    Sonestedt E, Wirfalt E, Wallstrom P, Gullberg B, Orho-Melander M, Hedblad B (2011) Dairy products and its association with incidence of cardiovascular disease: the Malmo diet and cancer cohort. Eur J Epidemiol 26:609–618

    Article  CAS  Google Scholar 

  43. 43.

    Malik VS, Sun Q, van Dam RM, Rimm EB, Willett WC, Rosner B, Hu FB (2011) Adolescent dairy product consumption and risk of type 2 diabetes in middle-aged women. Am J Clin Nutr 94:854–861

    Article  CAS  Google Scholar 

  44. 44.

    Choi HK, Willett WC, Stampfer MJ, Rimm E, Hu FB (2005) Dairy consumption and risk of type 2 diabetes mellitus in men: a prospective study. Arch Int Med 165:997–1003

    Article  Google Scholar 

  45. 45.

    Krachler B, Norberg M, Eriksson JW, Hallmans G, Johansson I, Vessby B, Weinehall L, Lindahl B (2008) Fatty acid profile of the erythrocyte membrane preceding development of Type 2 diabetes mellitus. Nutr Metab Cardiovasc Dis 18:503–510

    Article  CAS  Google Scholar 

  46. 46.

    Soedamah-Muthu SS, Masset G, Verberne L, Geleijnse JM, Brunner EJ (2012) Consumption of dairy products and associations with incident diabetes, CHD and mortality in the Whitehall II study. Br J Nutr [Epub ahead of print]

  47. 47.

    Biong AS, Veierod MB, Ringstad J, Thelle DS, Pedersen JI (2006) Intake of milk fat, reflected in adipose tissue fatty acids and risk of myocardial infarction: a case-control study. Eur J Clin Nutr 60:236–244

    Article  CAS  Google Scholar 

  48. 48.

    Sun Q, Ma J, Campos H, Hu FB (2007) Plasma and erythrocyte biomarkers of dairy fat intake and risk of ischemic heart disease. Am J Clin Nutr 86:929–937

    CAS  Google Scholar 

  49. 49.

    Warensjo E, Smedman A, Stegmayr B, Hallmans G, Weinehall L, Vessby B, Johansson I (2009) Stroke and plasma markers of milk fat intake: a prospective nested case-control study. Nutr J 8:21

    Article  Google Scholar 

  50. 50.

    Smit LA, Baylin A, Campos H (2010) Conjugated linoleic acid in adipose tissue and risk of myocardial infarction. Am J Clin Nutr 92:34–40

    Article  CAS  Google Scholar 

  51. 51.

    Hu FB, Stampfer MJ, Manson JE, Ascherio A, Colditz GA, Speizer FE, Hennekens CH, Willett WC (1999) Dietary saturated fats and their food sources in relation to the risk of coronary heart disease in women. Am J Clin Nutr 70:1001–1008

    CAS  Google Scholar 

  52. 52.

    Larsson SC, Mannisto S, Virtanen MJ, Kontto J, Albanes D, Virtamo J (2009) Dairy foods and risk of stroke. Epidemiology 20:355–360

    Article  Google Scholar 

  53. 53.

    Goldbohm RA, Chorus AM, Galindo Garre F, Schouten LJ, van den Brandt PA (2011) Dairy consumption and 10-y total and cardiovascular mortality: a prospective cohort study in the Netherlands. Am J Clin Nutr 93:615–627

    Article  CAS  Google Scholar 

  54. 54.

    Bonthuis M, Hughes MC, Ibiebele TI, Green AC, van der Pols JC (2010) Dairy consumption and patterns of mortality of Australian adults. Eur J Clin Nutr 64:569–577

    Article  CAS  Google Scholar 

  55. 55.

    Dalmeijer GW, Struijk EA, van der Schouw YT, Soedamah-Muthu SS, Verschuren WM, Boer JM, Geleijnse JM, Beulens JW (2012) Dairy intake and coronary heart disease or stroke-A population-based cohort study. Int J Cardiol [Epub ahead of print]

  56. 56.

    Lockheart MS, Steffen LM, Rebnord HM, Fimreite RL, Ringstad J, Thelle DS, Pedersen JI, Jacobs DR Jr (2007) Dietary patterns, food groups and myocardial infarction: a case-control study. Br J Nutr 98:380–387

    Article  CAS  Google Scholar 

  57. 57.

    Ness AR, Smith GD, Hart C (2001) Milk, coronary heart disease and mortality. J Epi Commun Health 55:379–382

    Article  CAS  Google Scholar 

  58. 58.

    Hjerpsted J, Leedo E, Tholstrup T (2011) Cheese intake in large amounts lowers LDL-cholesterol concentrations compared with butter intake of equal fat content. Am J Clin Nutr 94:1479–1484

    Article  CAS  Google Scholar 

  59. 59.

    Laake I, Pedersen JI, Selmer R, Kirkhus B, Lindman AS, Tverdal A, Veierod MB (2011) A prospective study of intake of trans-fatty acids from ruminant fat, partially hydrogenated vegetable oils, and marine oils and mortality from CVD. Br J Nutr [Epub ahead of print]

  60. 60.

    Mozaffarian D, Katan MB, Ascherio A, Stampfer MJ, Willett WC (2006) Trans fatty acids and cardiovascular disease. N Engl J Med 354:1601–1613

    Article  CAS  Google Scholar 

  61. 61.

    Wang H, Steffen LM, Vessby B, Basu S, Steinberger J, Moran A, Jacobs DR Jr, Hong CP, Sinaiko AR (2011) Obesity modifies the relations between serum markers of dairy fats and inflammation and oxidative stress among adolescents. Obesity 19:2404–2410

    Article  CAS  Google Scholar 

  62. 62.

    Jensen RG (2002) The composition of bovine milk lipids: January 1995 to December 2000. J Dairy Res 85:295–350

    Article  CAS  Google Scholar 

  63. 63.

    Kelly GS (2001) Conjugated linoleic acid: a review. Altern Med Rev 6:367–382

    CAS  Google Scholar 

  64. 64.

    Dhiman TR, Nam SH, Ure AL (2005) Factors affecting conjugated linoleic acid content in milk and meat. Crit Rev Food Sci Nutr 45:463–482

    Article  CAS  Google Scholar 

  65. 65.

    Lambert EV, Goedecke JH, Bluett K, Heggie K, Claassen A, Rae DE, West S, Dugas J, Dugas L, Meltzeri S, Charlton K, Mohede I (2007) Conjugated linoleic acid versus high-oleic acid sunflower oil: effects on energy metabolism, glucose tolerance, blood lipids, appetite and body composition in regularly exercising individuals. Br J Nutr 97:1001–1011

    Article  CAS  Google Scholar 

  66. 66.

    Joseph SV, Jacques H, Plourde M, Mitchell PL, McLeod RS, Jones PJ (2011) Conjugated linoleic acid supplementation for 8 weeks does not affect body composition, lipid profile, or safety biomarkers in overweight, hyperlipidemic men. J Nutr 141:1286–1291

    Article  CAS  Google Scholar 

  67. 67.

    Petridou A, Mougios V, Sagredos A (2003) Supplementation with CLA: isomer incorporation into serum lipids and effect on body fat of women. Lipids 38:805–811

    Article  CAS  Google Scholar 

  68. 68.

    Zambell KL, Keim NL, Van Loan MD, Gale B, Benito P, Kelley DS, Nelson GJ (2000) Conjugated linoleic acid supplementation in humans: effects on body composition and energy expenditure. Lipids 35:777–782

    Article  CAS  Google Scholar 

  69. 69.

    Tricon S, Burdge GC, Kew S, Banerjee T, Russell JJ, Jones EL, Grimble RF, Williams CM, Yaqoob P, Calder PC (2004) Opposing effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid on blood lipids in healthy humans. Am J Clin Nutr 80:614–620

    CAS  Google Scholar 

  70. 70.

    Malpuech-Brugere C, Verboeket-van de Venne WP, Mensink RP, Arnal MA, Morio B, Brandolini M, Saebo A, Lassel TS, Chardigny JM, Sebedio JL, Beaufrere B (2004) Effects of two conjugated linoleic Acid isomers on body fat mass in overweight humans. Obesity Res 12:591–598

    Article  CAS  Google Scholar 

  71. 71.

    Riserus U, Berglund L, Vessby B (2001) Conjugated linoleic acid (CLA) reduced abdominal adipose tissue in obese middle-aged men with signs of the metabolic syndrome: a randomised controlled trial. Int J Obes 25:1129–1135

    Article  CAS  Google Scholar 

  72. 72.

    Gaullier JM, Halse J, Hoye K, Kristiansen K, Fagertun H, Vik H, Gudmundsen O (2005) Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. J Nutr 135:778–784

    CAS  Google Scholar 

  73. 73.

    Mougios V, Matsakas A, Petridou A, Ring S, Sagredos A, Melissopoulou A, Tsigilis N, Nikolaidis M (2001) Effect of supplementation with conjugated linoleic acid on human serum lipids and body fat. J Nutr Biochem 12:585–594

    Article  CAS  Google Scholar 

  74. 74.

    Watras AC, Buchholz AC, Close RN, Zhang Z, Schoeller DA (2007) The role of conjugated linoleic acid in reducing body fat and preventing holiday weight gain. Int J Obes 31:481–487

    Article  CAS  Google Scholar 

  75. 75.

    Thom E, Wadstein J, Gudmundsen O (2001) Conjugated linoleic acid reduces body fat in healthy exercising humans. J Int Med Res 29:392–396

    CAS  Google Scholar 

  76. 76.

    Blankson H, Stakkestad JA, Fagertun H, Thom E, Wadstein J, Gudmundsen O (2000) Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr 130:2943–2948

    CAS  Google Scholar 

  77. 77.

    Whigham LD, Watras AC, Schoeller DA (2007) Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Am J Clin Nutr 85:1203–1211

    CAS  Google Scholar 

  78. 78.

    Tricon S, Burdge GC, Jones EL, Russell JJ, El-Khazen S, Moretti E, Hall WL, Gerry AB, Leake DS, Grimble RF, Williams CM, Calder PC, Yaqoob P (2006) Effects of dairy products naturally enriched with cis-9, trans-11 conjugated linoleic acid on the blood lipid profile in healthy middle-aged men. Am J Clin Nutr 83:744–753

    CAS  Google Scholar 

  79. 79.

    Moloney F, Yeow TP, Mullen A, Nolan JJ, Roche HM (2004) Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus. Am J Clin Nutr 80:887–895

    CAS  Google Scholar 

  80. 80.

    Riserus U, Arner P, Brismar K, Vessby B (2002) Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care 25:1516–1521

    Article  CAS  Google Scholar 

  81. 81.

    Riserus U, Vessby B, Arnlov J, Basu S (2004) Effects of cis-9, trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. Am J Clin Nutr 80:279–283

    CAS  Google Scholar 

  82. 82.

    Syvertsen C, Halse J, Hoivik HO, Gaullier JM, Nurminiemi M, Kristiansen K, Einerhand A, O’Shea M, Gudmundsen O (2007) The effect of 6 months supplementation with conjugated linoleic acid on insulin resistance in overweight and obese. Int J Obes 31:1148–1154

    Article  CAS  Google Scholar 

  83. 83.

    Whigham LD, O’Shea M, Mohede IC, Walaski HP, Atkinson RL (2004) Safety profile of conjugated linoleic acid in a 12-month trial in obese humans. Food Chem Toxicol 42:1701–1709

    Article  CAS  Google Scholar 

  84. 84.

    Smedman A, Basu S, Jovinge S, Fredrikson GN, Vessby B (2005) Conjugated linoleic acid increased C-reactive protein in human subjects. Br J Nutr 94:791–795

    Article  CAS  Google Scholar 

  85. 85.

    Riserus U, Basu S, Jovinge S, Fredrikson GN, Arnlov J, Vessby B (2002) Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein: a potential link to fatty acid-induced insulin resistance. Circulation 106:1925–1929

    Article  CAS  Google Scholar 

  86. 86.

    Sofi F, Buccioni A, Cesari F, Gori AM, Minieri S, Mannini L, Casini A, Gensini GF, Abbate R, Antongiovanni M (2010) Effects of a dairy product (pecorino cheese) naturally rich in cis-9, trans-11 conjugated linoleic acid on lipid, inflammatory and haemorheological variables: a dietary intervention study. Nutr Metab Cardiovasc Dis 20:117–124

    Article  CAS  Google Scholar 

  87. 87.

    Bach Knudsen KE, Serena A, Canibe N, Juntunen KS (2003) New insight into butyrate metabolism. Proc Nutr Soc 62:81–86

    Article  Google Scholar 

  88. 88.

    Segain JP, Raingeard de la Bletiere D, Bourreille A, Leray V, Gervois N, Rosales C, Ferrier L, Bonnet C, Blottiere HM, Galmiche JP (2000) Butyrate inhibits inflammatory responses through NFkappaB inhibition: implications for Crohn’s disease. Gut 47:397–403

    Article  CAS  Google Scholar 

  89. 89.

    Lewis K, Lutgendorff F, Phan V, Soderholm JD, Sherman PM, McKay DM (2010) Enhanced translocation of bacteria across metabolically stressed epithelia is reduced by butyrate. Inflammatory Bowel Dis 16:1138–1148

    Article  Google Scholar 

  90. 90.

    Di Sabatino A, Morera R, Ciccocioppo R, Cazzola P, Gotti S, Tinozzi FP, Tinozzi S, Corazza GR (2005) Oral butyrate for mildly to moderately active Crohn’s disease. Aliment Pharmacol Therapeu 22:789–794

    Article  Google Scholar 

  91. 91.

    Gao Z, Yin J, Zhang J, Ward RE, Martin RJ, Lefevre M, Cefalu WT, Ye J (2009) Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes 58:1509–1517

    Article  CAS  Google Scholar 

  92. 92.

    Xiong Y, Miyamoto N, Shibata K, Valasek MA, Motoike T, Kedzierski RM, Yanagisawa M (2004) Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. PNAS USA 101:1045–1050

    Article  CAS  Google Scholar 

  93. 93.

    Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GS (2005) Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab 1:107–119

    Article  CAS  Google Scholar 

  94. 94.

    Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS (2008) Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell 134:933–944

    Article  CAS  Google Scholar 

  95. 95.

    Dimopoulos N, Watson M, Sakamoto K, Hundal HS (2006) Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells. Biochem J 399:473–481

    Article  CAS  Google Scholar 

  96. 96.

    Stefan N, Kantartzis K, Celebi N, Staiger H, Machann J, Schick F, Cegan A, Elcnerova M, Schleicher E, Fritsche A, Haring HU (2010) Circulating palmitoleate strongly and independently predicts insulin sensitivity in humans. Diabetes Care 33:405–407

    Article  CAS  Google Scholar 

  97. 97.

    Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS (2010) Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes. Am J Clin Nutr 92:1350–1358

    Article  CAS  Google Scholar 

  98. 98.

    Verhoeven NM, Jakobs C (2001) Human metabolism of phytanic acid and pristanic acid. Prog Lipid Res 40:453–466

    Article  CAS  Google Scholar 

  99. 99.

    Hostetler HA, Kier AB, Schroeder F (2006) Very-long-chain and branched-chain fatty acyl-CoAs are high affinity ligands for the peroxisome proliferator-activated receptor alpha (PPARalpha). Biochemistry 45:7669–7681

    Article  CAS  Google Scholar 

  100. 100.

    Zomer AW, van Der Burg B, Jansen GA, Wanders RJ, Poll-The BT, van Der Saag PT (2000) Pristanic acid and phytanic acid: naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor alpha. J Lipid Res 41:1801–1807

    CAS  Google Scholar 

  101. 101.

    Lemotte PK, Keidel S, Apfel CM (1996) Phytanic acid is a retinoid X receptor ligand. Eur J Biochem 236:328–333

    Article  CAS  Google Scholar 

  102. 102.

    Hellgren LI (2010) Phytanic acid: an overlooked bioactive fatty acid in dairy fat? Ann NY Acad Sci 1190:42–49

    Article  CAS  Google Scholar 

  103. 103.

    Heim M, Johnson J, Boess F, Bendik I, Weber P, Hunziker W, Fluhmann B (2002) Phytanic acid, a natural peroxisome proliferator-activated receptor (PPAR) agonist, regulates glucose metabolism in rat primary hepatocytes. FASEB J 16:718–720

    CAS  Google Scholar 

  104. 104.

    Schluter A, Barbera MJ, Iglesias R, Giralt M, Villarroya F (2002) Phytanic acid, a novel activator of uncoupling protein-1 gene transcription and brown adipocyte differentiation. Biochem J 362:61–69

    Article  CAS  Google Scholar 

  105. 105.

    United States Department of Agriculture Economic Research Service (2011) http://www.ers.usda.gov. Accessed on November 25

  106. 106.

    Leiber F, Kreuzer M, Nigg D, Wettstein HR, Scheeder MR (2005) A study on the causes for the elevated n-3 fatty acids in cows’ milk of alpine origin. Lipids 40:191–202

    Article  CAS  Google Scholar 

  107. 107.

    Werner LB, Hellgren LI, Raff M, Jensen SK, Petersen RA, Drachmann T, Tholstrup T (2011) Effect of dairy fat on plasma phytanic acid in healthy volunteers: a randomized controlled study. Lipids Health Dis 10:95

    Article  CAS  Google Scholar 

  108. 108.

    Couvreur S, Hurtaud C, Marnet PG, Faverdin P, Peyraud JL (2007) Composition of milk fat from cows selected for milk fat globule size and offered either fresh pasture or a corn silage-based diet. J Dairy Res 90:392–403

    Article  CAS  Google Scholar 

  109. 109.

    Ferlay A, Agabriel C, Sibra C, Journal C, Martin B, Chilliard Y (2008) Tanker milk variability in fatty acids according to farm feeding and husbandry practices in a French semi-mountain area. Dairy Sci Technol 88:193–215

    Article  CAS  Google Scholar 

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All authors contributed to the writing of this manuscript.

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Correspondence to Mario Kratz.

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Kratz, M., Baars, T. & Guyenet, S. The relationship between high-fat dairy consumption and obesity, cardiovascular, and metabolic disease. Eur J Nutr 52, 1–24 (2013). https://doi.org/10.1007/s00394-012-0418-1

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Keywords

  • Milk fat
  • Dairy fat
  • Obesity
  • Adiposity
  • Diabetes
  • Cardiovascular disease