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Mucosal lesions may be a minor complication of SAPHO syndrome: a study of 11 Japanese patients with SAPHO syndrome

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Abstract

Since the term synovitis–acne–pustulosis–hyperostosis–osteitis (SAPHO) syndrome was proposed by Chamot et al. (Rev Rhum Mal Osteoartic 54:187–196, 1987), clinical reviews concerning this syndrome have been mainly reported from Europe. We carried out a retrospective analysis of 11 Japanese patients with SAPHO syndrome, and reviewed the clinical features of our series in comparison with those in a European large case study. In this study the major features of SAPHO syndrome were chronic osteitis of the anterior chest wall and pustulotic arthro-ostitis with middle age onset, and mucosal lesions seemed to be a minor complication of SAPHO syndrome. The non-erosive peripheral large joints arthritis and the particular HLA types (HLA-B51, B52, or A26), which had been reported to be increased in Behcet’s disease, were frequently seen in SAPHO syndrome with mucosal lesions. This study also suggests that SAPHO syndrome with mucosal lesions may be part of a broader disease spectrum including Behcet’s disease.

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Acknowledgments

The authors thank Dr. Kenichiro Matsuzaki, Dr. Masaaki Takahashi, Dr. Akio Yokoi (Department of Orthopaedic Surgery, National Hospital Organization Tokyo Medical Center), and Dr. Eiki Nomura (Department of Orthopaedic Surgery, Saitama Municipal Hospital) for their helpful discussion.

Conflict of interest statement

All authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Kawasaki Municipal Ida Hospital, Ida 2-27-1, Nakahara-ku, Kawasaki City, 211-0035, Japan

    Hiroki Yabe & Takahiro Koyanagi

  2. Department of Internal Medicine, National Hospital Organization Tokyo Medical Center, Tokyo, Japan

    Hisaji Ohshima

  3. Department of Ophthalmology, International University of Health and Welfare Mita Hospital, Tokyo, Japan

    Yoji Takano

  4. Department of Orthopaedic Surgery, National Hospital Organization Tokyo Medical Center, Tokyo, Japan

    Hiroshi Usui

  5. Department of Orthopaedic Surgery, Kawasaki Municipal Kawasaki Hospital, Kawasaki, Japan

    Kenya Nojiri, Kensuke Ochi, Michiya Kihara & Yukio Horiuchi

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  1. Hiroki Yabe
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  2. Hisaji Ohshima
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  4. Takahiro Koyanagi
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  9. Yukio Horiuchi
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Correspondence to Hiroki Yabe.

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Yabe, H., Ohshima, H., Takano, Y. et al. Mucosal lesions may be a minor complication of SAPHO syndrome: a study of 11 Japanese patients with SAPHO syndrome. Rheumatol Int 30, 1277–1283 (2010). https://doi.org/10.1007/s00296-009-1138-6

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  • DOI: https://doi.org/10.1007/s00296-009-1138-6

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