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Racial and ethnic variation of PSA in global population: Age specific reference intervals for serum prostate specific antigen in healthy South Indian males

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Abstract

The serum PSA is universally accepted as the useful and clinically relevant tumor marker for monitoring therapy and identifying early recurrence in patients of carcinoma prostate throughout the world. However, application of serum PSA is limited to screening for early adenocarcinoma prostate among males above fifty years of age.

Serum PSA concentration varies from one population to another in different parts of the world. Many groups of workers have selected 4 ng/ml of serum PSA as upper limit of normal range without giving due consideration for age specific increase in serum PSA. There is no single report available on normal decade wise age specific reference intervals for serum PSA in Indian males.

The present study is undertaken to establish age specific reference intervals in healthy Indian males from 20–89 years belonging to subpopulation of Andhra Pradesh from South India. Our results revealed lowest concentration of 95 percentile serum PSA in Indian males compared to other populations globally. Contrary to this, healthy Afro Americans were found to have highest concentration of serum PSA compared to all other populations.

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References

  1. Rock, R.C., Chan, D.W., Bruzek, D., Waldron, C., Oesterling, J.E. and Walsh, P. (1987) Evaluation of a monoclonal immuno-radiometric assay for prostate-specific antigen. Clin. Chem. 33, 2257–2261.

    PubMed  CAS  Google Scholar 

  2. Ercole, C.J., Lange, P.H., Mathisen, M., Chiou, R.K., Reddy, P.K. and Vessella, R.L. (1987) Prostate specific antigen and prostatic acid phosphatase in the monitoring and staging of patients with prostatic cancer. Am. J. Urol. 138, 1181–1184.

    CAS  Google Scholar 

  3. Myrtle, J.F. (1989) Normal levels of prostate specific antigen (PSA) In: Clinical Aspects of Prostate/cancer. Elsevier Science Publishing Company. New York, 183–189.

    Google Scholar 

  4. Oesterling, J.E., Jacobson, S.J., Chute, C.G., Guess, HA., Girman, C.J., Panser, L.A. and Lieber, M.M. (1993) Serum prostate-specific antigen in a community-based population of healthy men: Establishment of age-specific reference ranges. JAMA. 270, 860.

    Article  PubMed  CAS  Google Scholar 

  5. Dalkin, B.L., Ahmann, F. and Southwick, P. (1993) Derivation of normal prostate-specific antigen (PSA) level by age. J. Urol. 149, 413A.

    Google Scholar 

  6. Crawford, E.D. (1993) Report on the 1992 Prostate Cancer Awareness week. J. Urol. 149, 55A.

    Google Scholar 

  7. Chan, D.W., Bruzek, D.J., Osterling, J.E., Rock, R.C. and Walsh, P.C. (1987) Prostate-specific antigen as a marker for prostatic cancer: a monoclonal and polyclonal immunoassay compared. Clin. Chem. 33, 1916.

    PubMed  CAS  Google Scholar 

  8. Stamey, T.A., Yang, N., Hay, A.R., McNeal, J.E., Freiha, F.S. and Redwine, E. (1987) Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. New Engl. J. Med. 317, 909–916.

    PubMed  CAS  Google Scholar 

  9. Yang, N. (1989) Pros-Check PSA: a double antibody radioimmunoassay for prostate-specific antigen. In: Clinical Aspects of Prostate Cancer. Edited by W.J. Catalona, D.S. Coffey and J.P. Karr. Elsevier Science Publishing Company, New York. 172–178.

    Google Scholar 

  10. BM Multicentre International study PSA free (1996). Boerhringer Mannheim Lab Diagnostics, Mannheim, Germany.

  11. Curtis Mettlin., Peter, J. Littrup., Robert, A. Kane., Gerald, P. Murphy., Fred Lee., Arthur Chesley., Robert Badalament and Fatollah, K. Mostofi. (1994) Relative Sensitivity and Specificity of Serum Prostate Specific Antigen (PSA) Level compared with Age-Referenced PSA, PSA Density, and PSA Change- Data from the American Cancer Society National Prostate Cancer Detection Project. Cancer 74, 1615–1619.

    Article  PubMed  CAS  Google Scholar 

  12. Oesterling, J.E., Kumamoto, Y., Tsukamoto, T., Girman, C.J., Guess, H.A., Masumori, N., Jacobsen, S.J. and Lieber, M.M. (1995) Serum protstate-specific antigen in a community-based population of healthy Japanese men: lower values than for similarly aged white men. Br. J. Urol. 75, 347–353.

    Article  PubMed  CAS  Google Scholar 

  13. Thomas, D. Richardson and Oesterling, J.E. (1997) Age-specific reference ranges for serum prostate-specific antigen. Urol. Clin. N. Am. 24, 2, 339–364.

    Article  Google Scholar 

  14. Catalona, W.J., Hudson, M.A., Scardino, P.T., Richie, J.P., Ahmann, F.R., Flanigan, R.C., deKernion, J.B., Ratliff, T.L., Kavoussi, L.R. and Dalkin, B.L. (1994) Selection of optimal prostate specific antigen cutoffs for early detection of prostate cancer: receiver operating characteristic curves. J. Urol. 152, 2037–2042.

    PubMed  CAS  Google Scholar 

  15. Weinrich, M.C., Jacobsen, S.J., Weinrich, S.P., Moul, J.W., Oesterling, J.E., Jacobson, D. and Wise, R. (1998) Reference ranges for serum prostate-specific antigen in black and white men without cancer. Urology 52, 967–973.

    Article  PubMed  CAS  Google Scholar 

  16. Ted Morgan, O., Steven, J., Jacobsen., W.F., McCarthy, D.J., Jacobson, D.G., McLeod and Judd, W.M. (1996) Age Specific reference ranges for serum prostate specific Antigen in Black Men. New Engl. J. Med. 335, 304–310.

    Article  Google Scholar 

  17. Lin, W.Y., Gu, C.J., Kao, C.H., Changlai, S.P. and Wang, S.J. (1996) Serum prostate-specific anntigen in healthy Chinese men: establishment of age-specific reference ranges. Neoplasma 43, 103–105.

    PubMed  CAS  Google Scholar 

  18. Kao, C.H. (1997) Age-related free PSA, total PSA and free PSA/total PSA ratios: establishment of reference ranges in Chinese males. Anticancer Res. 17, 1361–1365.

    PubMed  CAS  Google Scholar 

  19. Saw, S. and Aw, T.C. (2000) Age-related reference intervals for free and total prostate-specific antigen in a Singaporean population. Pathology 32, 245–249.

    Article  PubMed  CAS  Google Scholar 

  20. Lee, S.E., Kwak, C., Park, M.S., Lee, C.H., Kang, W. and Oh, S.J. (2000) Ethnic differences in the age-related distribution of serum prostate-specific antigen values: a study in healthy Korean population. Urology 56, 1007–1010.

    Article  PubMed  CAS  Google Scholar 

  21. Atalay, A.C., Karaman, M.J., Guney, S., Dalkilic, A. Muslumanoglu, A.Y. and Ergenekon, E. (1998) Age-specific PSA reference ranges in a group of non-urologic patients. Int. Urol. Nephrol. 30, 587–591.

    Article  PubMed  CAS  Google Scholar 

  22. Anderson, J.R., Strickland, D., Corbin, D., Byrnes, J.A. and Zweiback, E. (1995) Age specific reference ranges for serum prostate-specific antigen. Urology 46, 54–57.

    Article  PubMed  CAS  Google Scholar 

  23. DeAntoni, E.P., Crawford, E.D., Oesterling, J.E., Ross, C.A., Berger, E.R., McLeod, D.G., Staggers, F. and Stone, N.N. (1996) Age-and race-specific reference ranges for prostate-specific antigen from a large community-based study. Urology 48, 234–239.

    Article  PubMed  CAS  Google Scholar 

  24. Cooney, K.A., Strawderman, M.S., Wojno, K.J., Doerr, K.M., Taylor, A., Alcser, K.H., Heeringa, S.G., Taylor, J.M., Wei, J.T., Montie, J.E. and Schottenfeld, D. (2001) Age-specific distribution of serum prostate-specific antigen in a community- based study of African-American men. Urology 57, 91–96.

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Biochemistry, Nizam’s Institute of Medical Sciences, Punjagutta, Hyderabad

    T. Malati & G. Rajani Kumari

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  1. T. Malati
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  2. G. Rajani Kumari
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Malati, T., Kumari, G.R. Racial and ethnic variation of PSA in global population: Age specific reference intervals for serum prostate specific antigen in healthy South Indian males. Indian J Clin Biochem 19, 132–137 (2004). https://doi.org/10.1007/BF02872408

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