Indian Journal of Clinical Biochemistry

, Volume 16, Issue 1, pp 1–8 | Cite as

An overview of monoclonal gammapathies

  • T. Malati


The neoplastic proliferation of single clones of plasma cells causes synthesis of very large amount of monoclonal immunoglobulins consisting of only one type of heavy either the gamma, alpha, mu, delta or epsilon chain or only kappa or lambda light chains. Each monoclonal immunolobulin differs idiotypically from each other. These monoclonal immunoglobulins are also called paraproteins and are frequently associated with a broad heterogeneous group of plasma cell dyscrasias. Occasionally their presence is observed in a few benign conditions and in old age. In the present review a detailed account of different types of monoclonal gammapathies are described.

Key words

Monoclonal gammapathies monoclonal immunoglobulins paraproteins myeloma proteins cancer M proteins 


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Copyright information

© Association of Clinical Biochemists of India 2001

Authors and Affiliations

  • T. Malati
    • 1
  1. 1.Department of BiochemistryNizam's Institute of Medical SciencesHyderabad

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