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An overview of monoclonal gammapathies

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Abstract

The neoplastic proliferation of single clones of plasma cells causes synthesis of very large amount of monoclonal immunoglobulins consisting of only one type of heavy either the gamma, alpha, mu, delta or epsilon chain or only kappa or lambda light chains. Each monoclonal immunolobulin differs idiotypically from each other. These monoclonal immunoglobulins are also called paraproteins and are frequently associated with a broad heterogeneous group of plasma cell dyscrasias. Occasionally their presence is observed in a few benign conditions and in old age. In the present review a detailed account of different types of monoclonal gammapathies are described.

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References

  1. Zawadzki, Z.A. and Edward, G.A. (1967) M component in immunoproliferative disorders: Electrophoretic and immunologic analysis of 200 cases. Amer. J. Clin. Path. 48, 418–430.

    CAS  Google Scholar 

  2. Cooke, J.B. (1969) Essential paraproteinemia. Proc. Roy. Soc. Med. 62, 777–778.

    PubMed  CAS  Google Scholar 

  3. Salmon, S.E. (1988) Plasma cell disorders. In: Cell Text book of Medicine. Eds. Wingarden, J.B. and Smith, L.H.Jr. 18th edn. p. 1026–1036.

  4. Aguzzi, F., Bergami, M.R., Gasparro, C. Bellotti, V. and Merlini, G. (1992) Occurrence of monoclonal components in general practice: clinical implications. Eur. J. Haematol. 48, 192–195.

    Article  PubMed  CAS  Google Scholar 

  5. Saimon, S.E. and Cassady, J.R. (1993) Plasma cell Neoplasm In: Cancer: Principles and Practice of Oncology Eds. Vincent, T. Devitta, Jr. Hellman, S. and Rosenberg, S.A. J.B. Lipp co., Philadelphia p. 1984–2025.

    Google Scholar 

  6. Karen, D.F. (1998) Detection and Characterization of Monoclonal components in serum and urine. Clin. Chem. 44, 1143–1145.

    Google Scholar 

  7. Patriarca, F., Fanin, R., Silvestri, F., Cardoni, A. and Zoya, F. (1999) Clinical features and outcome of multiple Myeloma arising from the transformation of a monoclonal gammapathy of undetermined significance. 34, 591–596.

    CAS  Google Scholar 

  8. Hobbs, J.R. (1971) Immunocytoma O'mice on men. Brit. Med. J. 2, 67.

    Article  PubMed  CAS  Google Scholar 

  9. Apitz, K. (1940) Die Paraproteinosen: Uber die Starung des Eiweisstoffwech sel bei Plasmocytom. Arch. Path. Anat. 306, 631–633.

    Article  Google Scholar 

  10. Waldenstrom, J. (1961) Studies on conditions associated with disturbed gammaglobulin formation: (gammapathies) Harvey Lectures. 56, 211–219.

    CAS  Google Scholar 

  11. Edelman, G.M. and Gall, W.E. (1969) Antibody problem. Ann. Rev. Biochem. 38, 415–466.

    Article  PubMed  CAS  Google Scholar 

  12. Jeme, N.K. (1985) The generative grammer of the immune system. The EMBO journal. 4, 847–852.

    Google Scholar 

  13. Martin, N.H. (1961) The incidence of myelomatasis. Lancet 1, 237–239.

    Article  PubMed  CAS  Google Scholar 

  14. Kyle, R.A. (1975) Multiple Myeloma. Review of 869 cases. Mayo Clinic. Proc. 50, 29–40.

    CAS  Google Scholar 

  15. Ameis, A., Ko, H.S. and Pruzanski, W. (1976) M-component—A review of 1242 cases. Can. Med. Asso. J., 114, 889–895.

    CAS  Google Scholar 

  16. Sehgal, S., Datta, U., Gulati, D.R., Grover, A. and Gupta, B.D. (1984) Spectrum of Lymphoid Malignancies with particular reference to Plasma cell Dyscrasias in Chandigarh, India In: Pathogenesis of Leukemias and Lymphomas: Environmental Influences Eds. Magrath I.T., O'Conor, G.T. and Ramot B. Raven Press, New York, p. 47–59.

    Google Scholar 

  17. Kyle, R.A., Finkeistein, S., Elveback, L.R., and Kuland T. (1972) Incidence of monocional proteins in a Minnesota community with a cluster of multiple myeloma. Blood. 40, 719–724.

    PubMed  CAS  Google Scholar 

  18. Kyle, R.A., Nobrega, F.T. and Kurland L.T. (1969) Multiple Myeloma in Olmsted county, Minnesota. 1945–1964 Blood. 33, 739–745.

    CAS  Google Scholar 

  19. Hobbs, J.R. and Jacobs, A. (1969) A half molecule GK plasmacytoma. Clin. Exper. Immunol. 5, 199–207.

    CAS  Google Scholar 

  20. Malati, T. and Gupta, R.M. (1981) Presence of structurally abnormal molecules in monoclonal Immunoglobulins in human myelomas. Ind. J. Med. Res. 73, 930–937.

    Google Scholar 

  21. Kyle, R.A., Robert, M.D. and Pien, R.V.C. (1970): Multiple myeloma and acute myelomonocytic leukemia. New Eng. J. Med. 283, 1121–1125.

    Article  PubMed  CAS  Google Scholar 

  22. Ko, H.S. and Pruzanskai, W. (1976) M components associated with lymphoma: a review of 62 cases. 272, 175–183.

    CAS  Google Scholar 

  23. Ward, A.M., Shortland, J.R. and Draka, C.S. (1971) Lymphosarcoma of the lung with monocional (IgM) gammapathy. A clinicopathologic, histochemical, immunologic and ultrastructural study. Cancer. 27, 1009.

    Article  PubMed  CAS  Google Scholar 

  24. Gupta, R.M., Malati, T. and Chakravorty, M. (1978) A noncryomonoclonal IgM with auto anti IgG activity in a case of lymphosarcoma. Ind. J. Med. Res. 67, 821–826.

    CAS  Google Scholar 

  25. Zawadzki, Z.A. and Edwards, G.A. (1972) Non myelomatous monocional immunoglobulinemia. Prog. Clin. Immunol. 1, 105–156.

    PubMed  CAS  Google Scholar 

  26. Young, V.H. (1969) Transient paraproteins. Proc. Roy. Soc. Med. 62, 778–786.

    PubMed  CAS  Google Scholar 

  27. Axelsson, U., Bachmann, R. and Hallen, J. (1966) Frequency of pathological proteins (M-component) in 6995 sera from an adult population. Acta. Med. Scandinav. 179, 235–247.

    CAS  Google Scholar 

  28. Yagi, Y. and Pressman, D. (1978) Monoclonal IgA and IgM in the serum of a single patient (SC). Sharing of individually specific determinants between IgA and IgM. J. Immunol. 110, 335–344.

    Google Scholar 

  29. Guamer, J., Austin, G.E., Nassar, W.H., Sarma, P.R. and Boedecker, E. (1986) Biclonal gammapathy (IgG kappa and IgA lambda) in a patient with non-Hodgkin's lymphoma. Arch. Path. Lab. Med. 110, 445–448.

    Google Scholar 

  30. Alami, S.Y., Reese, M.H. and Bowman, R.O. (1969) Lymphosarcoma with two serum IgG ‘M’ components of different L chain types. Amer. J. Clin. Path. 51, 185–193.

    CAS  Google Scholar 

  31. Ray, R.A., Schotters, S.B. and Jacobs, A. (1986) Triclonal gammapathy in a patient with plasma cell dyscrasias. Clin. Chem. 32, 205–206.

    PubMed  CAS  Google Scholar 

  32. Blatner, W.A., Blair, A. and Mason, T.J. (1981) Multiple myeloma in the USA 1952–1975. Cancer, 48, 2547–2552.

    Article  Google Scholar 

  33. Osserman, E.F., Merlini, G. and Butler, P.V. (1989) Multiple Myeloma and related plasma cell dyscrasias. J. Amer. Med. Assoc. 4, 354–361.

    Google Scholar 

  34. Takahashi, K., Yamamura, F. and Motoyama, H. (1986) IgM myeloma. Its distinction from Waldenstrom's macroglobulinemia. Acta. Path. Jap. 36, 1553–1563.

    PubMed  CAS  Google Scholar 

  35. Lindstrom, F.D. and Dahistrom, U. (1978) Multiple myeloma or benign monoclonal gammapathy? A study of differential diagnostic criteria in 44 cases. Clin. Immunol. Immunopathol. 10, 168–174.

    Article  PubMed  CAS  Google Scholar 

  36. Fishkin, B.G. Natalie, O. and Louis, E.S. (1972) IgE multiple myeloma. A report of the third case Blood. 39, 361–367.

    PubMed  CAS  Google Scholar 

  37. Rowe, D.S. and Fahey, J.L. (1985) A new class of human immunoglobulins. 1. A unique myeloma protein. J. Exp. Med. 121, 171–184.

    Article  Google Scholar 

  38. Hobbs, J.R. (1966) Six cases of gamma-D myelometosis. Lancet. 2, 614–618.

    Article  PubMed  CAS  Google Scholar 

  39. Hurez, D., Flandrin, G., Preud'homme, J.L. and Seligmann, M. (1972) Unreleased intracellular monoclonal macroglobulin in chronic lymphocytic leukemia. Clin. Exp. Immunol. 10, 223–234.

    PubMed  CAS  Google Scholar 

  40. Gupta, Malati, T., Gupta, R.M. and Khanna, N. (1974) Monoclonal IgG cryoglobulin in multiple myeloma. A case report brief review of literature. J. Ass. Phy. Ind. 22, 51–57.

    CAS  Google Scholar 

  41. Virella, G. and Hobbs, J.R. (1971) Heavy chain typing in IgG Monoclonal gammapathies with special reference to cases of serum hyperviscosity and cryoglobulinemia. Clin. Exp. Immunol. 9, 973–980.

    Google Scholar 

  42. Liss, M., Fudenberg, H.H. and Kritzman, J. (1967) A Bence Jones cryoglobulin. Clinical, physical and immunological properities. Clin. Exp. Immunol. 2, 467–475.

    PubMed  CAS  Google Scholar 

  43. Meltzer, M. and Franklin, E.C. (1966) Cryoglobulinermia. A study of 29 patients. 1. IgG and IgM cryoglobulins and factors affecting cryoprecipitability. Amer. J. Med. 40, 828–836.

    Article  PubMed  CAS  Google Scholar 

  44. Waldenstrom, J. (1944) Incipient myelometosis or essential hyperglobulinemia with fibrinogenopenia—a new syndrome? Acta. Med. Scand. 117, 216–218.

    Article  Google Scholar 

  45. Krajny, M. and Pruzanski, W. (1976) Waldenstrom's macroglobulinemia: Review of 45 cases. Can. Med. Assoc. J. 114, 899–905.

    PubMed  CAS  Google Scholar 

  46. Waldenstrom, J. (1965) Macroglobulinemia. Adv. Metab. Dis. 2, 115

    CAS  Google Scholar 

  47. Kyle, R.A., Maldonado, J. and Bayrd, E.D. (1974) Plasma cell leukemia report on seventeen cases. Arch. Int. Med. 133, 813–815.

    Article  CAS  Google Scholar 

  48. Rasillo, A. and Miguel, J.F.S. (1999) Primary plasma cell leukemia. Clinical, immunophenotypic, DNA ploidy and cytogenetic characteristics. Blood. 93, 1032–1037.

    PubMed  Google Scholar 

  49. Corwin, J. and Lindberg, R.D. (1979) Solitary plasmacytoma of bone vs extramedullary plasma cytoma and their relationship to multiple myeloma. Cancer. 43, 1007–1013.

    Article  PubMed  CAS  Google Scholar 

  50. Gupta, R.M., Roy, D.C., Gupta, I.M. and Khanna, S. (1974) Extramedullary plasmacytoma IgG type 1 presenting as mediastinal syndrome. Brit. J. Dis. Chest 68, 65–70.

    Article  PubMed  CAS  Google Scholar 

  51. Cousineau, S., Beauchamp, G. and Boileau, Jacques. (1986) Extramedullary Plasmacytoma associated with angiofollicular lymph node hyperplasia. Arch. Pathol. Lab. Med. 110, 157–158.

    PubMed  CAS  Google Scholar 

  52. Bloch, K.J., Lee, L., Mills, J.A. and Haber, E. (1973) Gamma heavy chain disease—an expanding clinical and laboratory spectrum. Amer. J. Med. 55, 61–70.

    Article  PubMed  CAS  Google Scholar 

  53. Kyle, R.A., Greipp, P.R. and Banks, P.M. (1981) The diverse picture of gamma heavy chain disease: Report of 7 cases and review of literature. Mayo. Clin. Proc. 56, 439–451.

    PubMed  CAS  Google Scholar 

  54. Seligmann, M. and Rambaud, J.C. (1983) Alpha chain disease: An immunoproliferative disease of the secretory immune system. Ann. N.Y. Acad. Sci. 409, 478–484.

    Article  PubMed  CAS  Google Scholar 

  55. Bonhomme, J., Seligman, M., Mihaesco, C., Clauvel, J.P. and Danon, F. (1974) Mu-chain disease in an African patient. Blood, 43, 485–492.

    PubMed  CAS  Google Scholar 

  56. Bence Jones, H (1847) Papers on chemical pathology; prefaced by the galstonean lecture read at the Royal college of Physicians. Lecture 3, Lancet. 2, 88–92.

    Article  Google Scholar 

  57. Solomon, A., Waldmann, T.A. and Fahey, J.L. (1964) Metabolism of Bence Jones proteins. J. Clin. Invest. 43, 103–117.

    Article  PubMed  CAS  Google Scholar 

  58. Subba Rao, K. and Jacobson, H.G. (1986) Amyloidosis and plasma cell dyscrasias of the musculoskeletal system. Seminars in Roentgenology 21, 139–149.

    Article  CAS  Google Scholar 

  59. Glenner, G.G. (1980) Arnyloid deposits and amyloidosis: The B fibrilloses. New Eng. J. Med. 302, 1283–1291.

    Article  PubMed  CAS  Google Scholar 

  60. Anthony, N., Michael, N.K. and Liselotte, H. (1986) Amyloidosis presenting in the lower respiratory tract. Arch. Path. Lab Med. 110, 212–218.

    Google Scholar 

  61. Hallen, J. (1963) Frequency of abnormal serum globulins (M components) in the aged. Acta. Med. Scand. 173: 737–744, 1963.

    Article  PubMed  CAS  Google Scholar 

  62. Englisova, M., Englis, M. and Kyral, V. (1968) Changes of immunoglobulin synthesis in old people. Exp. Geront. 3, 125–127.

    Article  CAS  Google Scholar 

  63. Osby, E., Norning, L. and Hast, R. (1982) Benign monoclonal gammapathy and peripheral neuropathy. Brit. J. Haematol. 51, 531–539.

    Article  CAS  Google Scholar 

  64. Kyle, R.A. (1993) Benign monoclonal gammapathy after 30 to 35 years of follow up. Mayo. Clin. Proc. 68, 26–36.

    PubMed  CAS  Google Scholar 

  65. Zawadzki, Z.A., and Edwards, G.A. (1970) Pseudoparaproteinemia due to hypertransferrinemia. Amer. J. Clin. Path. 54, 802–809.

    CAS  Google Scholar 

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  1. Department of Biochemistry, Nizam's Institute of Medical Sciences, Panjagutta, 500082, Hyderabad, Andhra Pradesh

    T. Malati

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Malati, T. An overview of monoclonal gammapathies. Indian J Clin Biochem 16, 1–8 (2001). https://doi.org/10.1007/BF02867561

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