Abstract
A simple, selective and quantitative estimation of tranylcypromine using liquid chromatography and electrochemical detection with apomorphine as internal standard in human plasma is described. Sample preparation is done by liquid-liquid extraction. The absolute mean recovery of apomorphine is 95%, the recovery of tranylcypromine is 81%. This method gives a simple estimation method to assay plasma concentrations of tranylcypromine in the therapeutic range (5–200 ng/ml) with good reproducibility and linearity.
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Krugers Dagneaux, P.G.L.C., Loohuis, C.P.G.G., Klein Elhorst, J.T. et al. Liquid chromatographic estimation of tranylcypromine in human plasma. Pharmaceutisch Weekblad Scientific Edition 14, 46–49 (1992). https://doi.org/10.1007/BF01980481
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DOI: https://doi.org/10.1007/BF01980481