Abstract
Nowadays, it is generally agreed that intensive investigation of biosynthetic pathways is a prerequisite for attaining industrial-scale production of secondary metabolites (e.g. quinones) by plant cell cultures. Literature data are presented to illustrate different aspects of today's quinone biosynthesis research.
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References
Thomson RH. Naturally occurring quinones. III. London: Chapman and Hall, 1987.
Van den Berg AJJ, Labadie RP. Quinones. In: Dey PM, Harborne JB, eds. Methods in plant biochemistry. Vol. 1. London: Academic Press, 1989:451–91.
Kitanaka S, Igarashi H, Takido M. Formation of pigments by the tissue culture ofCassia occidentalis. Chem Pharm Bull 1985;33:971–4.
Inouye H, Matsumura H, Kawasaki M, Inoue K, Tsukada M, Tabata M. Two quinones from callus cultures ofEchium lycopsis. Phytochemistry 1981;20:1701–5.
Yazaki K, Fukui H, Tabata M. Dihydroshikonofuran, an unusual metabolite of quinone biosynthesis inLithospermum cell cultures. Chem Pharm Bull 1987;35:898–901.
Curtin ME. Harvesting profitable products from plant tissue culture. Biotechnology 1983;1:649–57.
Stöckigt J, Schübel H. Naturstoffe aus pflanzlichen Zellkulturen. Dtsch Apoth Ztg 1989;129:1187–92.
Khouri HE, Ibrahim RK. Purification and some properties of five anthraquinone-specific glucosyl-transferases fromCinchona succirubra cell suspension culture. Phytochemistry 1987;26:2531–5.
Mann J. Secondary metabolism. Oxford: Oxford University Press, 1978:1–77.
Vickery ML, Vickery B. Secondary plant metabolism. London: MacMillan Press, 1981:56–111.
Van den Berg AJJ, Radema MH, Labadie RP. Effects of light on anthraquinone production inRhamnus purshiana suspension cultures. Phytochemistry 1988;27:415–7.
Häggblom P. Light effects on polyketide and lipid metabolism inAlternaria alternata. Int Bot Congr Abstr 1987;17:174.
Mosbach K, Bävertoft I. A comparative study on the biosynthesis of palmitic and orsellinic acids inPenicillium baarnense. Acta Chem Scand 1971;25:1931–6.
Orvehed M, Häggblom P, Söderhäll K. Activity of NADPH-generating pathways in relation to polyketide synthesis in the fungusAlternaria alternata. Exp Mycol 1987;11:187–96.
Gstraunthaler GJA. The effect of cerulenin on fatty acid and anthraquinone biosynthesis in vegetative mycelia ofCortinarius orichalceus Fr. Biochim Biophys Acta 1983;750:424–7.
Omura S. Philosophy of new drug discovery. Microbiol Rev 1986;50:259–79.
Dusek J, Sicha J, Duskova J. Influence on the production of anthracene derivatives in the tissue culture ofRheum palmatum by a modification of the cultivating medium, or potential precursors. Cesk Farm 1989;38:210–3.
Van den Berg AJJ, Radema MH, Labadie RP. Influence of acetate and malonate on the production of 1,8-dihydroxyanthracene derivatives in suspension cultures ofRhamnus purshiana. Planta 1988;174:417–21.
Yagi A, Shoyama Y, Nishioka I. Formation of tetrahydroanthracene glucosides by callus tissue ofAloe saponaria. Phytochemistry 1983;22:1483–4.
Grün M, Franz G.In vitro biosynthesis of the C-glycosidic bond in aloin. Planta 1981;152:562–4.
Grün M, Franz G. Untersuchungen zur Biosynthese der Aloine inAloe arborescens Mill. Arch Pharm 1982;315:231–41.
Simantiras M, Leistner E. Formation ofo-succinylbenzoic acid from iso-chorismic acid in protein extracts from anthraquinone-producing plant cell suspension cultures. Phytochemistry 1989;28:1381–2.
Inouye H, Ueda S, Inoue K, Shiobara Y. (2R)-Catalponone, a biosynthetic intermediate for prenylnaphthoquinone congeners of the wood ofCatalpa ovata. Phytochemistry 1981;20:1707–10.
Inoue K, Ueda S, Nayeshiro H, Inouye H. Quinones fromStreptocarpus dunnii. Phytochemistry 1983;22:737–41.
Inoue K, Ueda S, Nayeshiro H, Moritome N, Inouye H. Biosynthesis of naphthoquinones and anthraquinones inStreptocarpus dunnii cell cultures. Phytochemistry 1984;23:313–8.
Mulder-Krieger Th, Verpoorte R, De Water A, Van Gessel M, Van Oeveren BCJA, Baerheim Svendsen A. Identification of the alkaloids and anthraquinones inCinchona ledgeriana callus cultures. Planta Med 1982;46:19–24.
Wijnsma R, Van Weerden IN, Verpoorte R, et al. Anthraquinones inCinchona ledgeriana bark infected withPhytophthora cinnamomi. Planta Med 1986;52:211–2.
Wijnsma R, Go JTKA, Van Weerden IN, Harkes PAA, Verpoorte R, Baerheim Svendsen A. Anthraquinones as phytoalexins in cell and tissue cultures ofCinchona spec. Plant Cell Rep 1985;4:241–4.
Igbavboa U, Sieweke HJ, Leistner E, Röwer I, Hüsemann W, Barz W. Alternative formation of anthraquinones and lipoquinones in heterotrophic and photoautotrophic cell suspension cultures ofMorinda lucida Benth. Planta 1985;166:537–44.
El-Shagi H, Shulte U, Zenk MH. Specific inhibition of anthraquinone formation by amino compounds inMorinda cell cultures. Naturwissenschaften 1984;71:267.
Inouye H, Ueda S, Inoue K, Matsumura H. Biosynthesis of shikonin in callus cultures ofLithospermum erythrorhizon. Phytochemistry 1979;18:1301–8.
Fukui H, Tsukada M, Mizukami H, Tabata M. Formation of stereoisomeric mixtures of naphthoquinone derivatives inEchium lycopsis callus cultures. Phytochemistry 1983;22:453–6.
Fukui H, Yoshikawa N, Tabata M. Induction of benzoquinone formation by activated carbon inLithospermum erythrorhizon cell suspension cultures. Phytochemistry 1984;23:301–5.
Heide L, Nishioka N, Fukui H, Tabata M. Enzymatic regulation of shikonin biosynthesis inLithospermum erythrorhizon cell cultures. Phytochemistry 1989;28:1873–7.
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Based on a lecture given at the 16th LOF Symposium, 27 October 1989, Utrecht, the Netherlands.
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Van den Berg, A.J.J. Biotechnology and biosynthesis of quinones. Pharmaceutisch Weekblad Scientific Edition 13, 74–77 (1991). https://doi.org/10.1007/BF01974984
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DOI: https://doi.org/10.1007/BF01974984