Skip to main content
Log in

Helicobacter pylori in gastroduodenal disease

  • Review Articles
  • Published:
Pharmaceutisch Weekblad Aims and scope Submit manuscript

Abstract

Helicobacter pylori is a recently described Gram-negative micro-organism, which plays an important role in the pathogenesis of peptic ulcer disease and gastritis. In this paper an outline is given of the history and the pathophysiology ofHelicobacter pylori, as well as the therapeutic studies aimed at eradication of the bacterium in various clinical entities.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Bizzozero G. Über die schlauchformigen Drusen des Magendarmkanals un die Beziehung ihres Epithels zu dem Oberflachen Epithel der Sleimhaut. Arch F Mikro Anayo 1893;42:82.

    Google Scholar 

  2. Krienitz W. Über das Auftreten von Mageninhalt bei Carcinoma ventriculi. Dtsch Med Wochenschr 1906;22:872.

    Google Scholar 

  3. Rosenow EC, Sandford AH. The bacteriology of ulcer of the stomach and duodenum in man. J Infect Dis 1915;17:219–26.

    Google Scholar 

  4. Doenges JL. Spirochetes in the gastric glands of Macacus rhesus and man without related disease. Arch Pathol 1939;27:469–77.

    Google Scholar 

  5. Freedburg AS, Barron LE. The presence of spirochetes in human gastric mucosa. Am J Dig Dis 1940;7:443–5.

    Google Scholar 

  6. Steer HW, Collin-Jones DG. Mucosal changes in gastric ulceration and their response to carbenoxolone sodium. Gut 1975;16:590–7.

    PubMed  Google Scholar 

  7. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984;1:1311–5.

    Article  PubMed  Google Scholar 

  8. Anonymous.Campylobacter pylori becomesHeliobacter pylori. Lancet 1989;2:1019–20.

  9. Marshall BJ, Royce H, Anneer DI, et al. Original isolation ofCampylobacter pyloridis from human gastric mucosa. Microbios Lett 1984;25:83–8.

    Google Scholar 

  10. Loffeld RJFL, Potters HVPJ, Arends JW, Stobberingh E, Flendrig JA, Van Spreeuwel JP.Campylobacter associated gastritis in patients with non-ulcer dyspepsia. J Clin Pathol 1988;41:84–8.

    Google Scholar 

  11. Potters HVPJ, Loffeld RJLF, Stobberingh E, Van Spreeuwel JP, Arends JW. Rapid staining ofCampylobacter pyloridis. Histopathology 1987;11:1223.

    Google Scholar 

  12. Montgomery EA, Martin DF, Peura DA. Rapid diagnosis ofCampylobacter pylori by Gram's stain. Am J Clin Pathol 1988;90:606–9.

    PubMed  Google Scholar 

  13. Walters LL, Budin RE, Paull G. Acridine orange to identifyCampylobacter pyloridis in formalin fixed paraffin-embedded gastric biopsies. Lancet 1986;1:42.

    Article  Google Scholar 

  14. Kaldor J, Tee W, McCarthy P, Watson J, Dwyer B. Immune respons toCampylobacter pyloridis in patients with peptic ulceration. Lancet 1985;1:921.

    Article  Google Scholar 

  15. Von Wulffen H, Heesemann J, Buetzow GH, Loening T, Laufs R. Detection ofCampylobacter pyloridis in patients with antrum gastritis and peptic ulcers by culture, complement fixation test, and immunoblot. J Clin Microbiol 1986;24:716–20.

    PubMed  Google Scholar 

  16. Loffeld RJLF, Stobberingh E, Flendrig JA, Van Spreeuwel JP, Arends JW. Diagnostic value of an immunoassay to detect antiCampylobacter pylori anti-bodies in non-ulcer dyspepsia. Lancet 1989;1:1182–5.

    Article  PubMed  Google Scholar 

  17. Marshall BJ, McGechie DB, Rogers PA, Glancy RJ.Pyloric Campylobacter infection in gastroduodenal disease. Med J Aust 1985;142:439–44.

    PubMed  Google Scholar 

  18. McNulty CAM, Dent J, Wise R. Susceptibility of clinical isolates ofCampylobacter pyloridis to 11 anti-microbial agents. Antimicrob Agents Chemother 1985;28:837–8.

    PubMed  Google Scholar 

  19. McNulty CAM, Gearty JC, Crump B, et al.Campylobacter pyloridis and associated gastritis: investigator blind placebo controlled trial of bismuth salicylate and erythromycin ethylsuccinate. Br Med J 1986;293:645–9.

    Google Scholar 

  20. Mertens JCC, Dekker W, Ligtvoet EEJ, Blok P. Treatment failure of norfloxacin againstCampylobacter pylori and chronic gastritis in patients with nonulcerative dyspepsia. Antimicrob Agents Chemother 1989;33:256–7.

    PubMed  Google Scholar 

  21. Jones DM, Lessels AM, Eldridge J.Campylobacter-like organisms on the gastric mucosa: culture, histological and serological studies. J Clin Pathol 1984;37:1002–6.

    PubMed  Google Scholar 

  22. Buck GE, Gourley WK, Lee WK, Subramanyam K, Latimer JM, DiNuzzo AR. The relation ofCampylobacter pyloridis to gastric and peptic ulcer. J Infect Dis 1986;153:664–9.

    PubMed  Google Scholar 

  23. Marshall BJ, Armstrong JA, McGechie DB, Glancy J. Attempts to fulfill Koch's postulates for pyloricCampylobacter. Med J Aust 1985;142:436–9.

    PubMed  Google Scholar 

  24. Morris A, Nicholson G. Ingestion ofCampylobacter pyloridis causes gastritis and raised fasting pH. Am J Gastroenterol 1987;82:192–9.

    PubMed  Google Scholar 

  25. Goodwin CS, McCulloch RK, Armstrong JA, Wee SH. Unusual cellular fatty acids and distinctive ultrastructure in a new spiral bacterium (Campylobacter pyloridis) from the human gastric mucosa. J Med Microbiol 1985;19:257–67.

    PubMed  Google Scholar 

  26. Hazell SL, Lee A.Campylobacter pyloridis, urease, hydrogen ion back diffusion and gastric ulcers. Lancet 1986;2:15–7.

    Article  PubMed  Google Scholar 

  27. Slomiany BL, Bilski J, Munty UL, et al.Campylobacter pyloridis degrades mucin and undermines gastric mucosal integrity. Gastroenterology 1987;92:1645.

    Google Scholar 

  28. Leunk RD, Johnson PT, David BL, Kraft WG, Morgan DR. Identification off cytotoxic activity produced byCampylobacter pyloridis. In:Campylobacter IV. Proceedings of the 4th International Workshop onCampylobacter Infections. Kopenhagen (in press).

  29. Baskerville A, Newell DG. Natural occurring chronic gastritis andCampylobacter pylori infection in the rhesus monkey: a potential model for gastritis in man. Gut 1988;29:465–72.

    PubMed  Google Scholar 

  30. Jones DM, Curry A. Ultrastructural study of gastricCampylobacter-like organisms (GCLO) from man, baboon, pig, and ferret. In:Campylobacter IV. Proceedings of the 4th International Workshop onCampylobacter Infections. Kopenhagen (in press).

  31. Talley NJ, Piper DW. The association between nonulcer dyspepsia and other gastrointestinal disorders. Scand J Gastroenterol 1985;20:896–900.

    PubMed  Google Scholar 

  32. Heatley RV, Rathbone BJ. Dyspepsia: a dilemma for doctors? Lancet 1987;1:779–81.

    Article  Google Scholar 

  33. Jones DM, Lessels AM, Eldridge J.Campylobacter-like organisms on gastric mucosa: culture, histological, and serological studies. J Clin Pathol 1984;37:1002–6.

    PubMed  Google Scholar 

  34. Barthel JS, Westblom TW, Heavy AD, Gonsalez F, Everet ED. Gastritis andCampylobacter pylori in healthy asymptomatic volunteers. Arch Intern Med 1988;148:1149–51.

    Article  PubMed  Google Scholar 

  35. Rokkas T, Pursey C, Uzoechina E, et al. Non-ulcer dyspepsia and short term De Nol therapy: a placebo controlled trial with particular reference to the roleCampylobacter pylori. Gut 1988;29:1386–91.

    PubMed  Google Scholar 

  36. Loffeld RJLF, Potters HVPJ, Stobberingh E, Van Spreeuwel JP, Flendrig JA, Arends JW.Campylobacter associated gastrits in patients with non-ulcer dyspepsia: a placebo controlled double blind trial with colloidal bismuth subcitrate. Gut 1989;30:1206–12.

    PubMed  Google Scholar 

  37. Glupczynski Y, Burette A, Labbe M, Deprez C, Reuck M, Deltenre M.Campylobacter pylori associated gastritis: a double blind placebo controlled trial with amoxycillin. Am J Gastroenterol 1988;83:365–72.

    PubMed  Google Scholar 

  38. Humphreys H, Bourke S, Dooley C, et al. Effect of treatment onCampylobacter pylori in peptic disease: a randomised prospective trial. Gut 1988;29:279–83.

    PubMed  Google Scholar 

  39. Morgan D, Kraft W, Bender M, Pearson A. Nitrofurans in the treatment of gastritis associated withCampylobacter pylori. Gastroenterology 1988;95:1178–84.

    PubMed  Google Scholar 

  40. Oderda G, Holton J, Altare F, Vaira D, Ainley C, Ansaldi N. Amoxycillin plus tinidazole forCampylobacter pylori gastritis in children: assessment by serum IgG antibody, pepsinogen I and gastrin. Lancet 1989;1:690–2.

    Article  PubMed  Google Scholar 

  41. Goodwin CS. Duodenal ulcer,Campylobacter pylori, and the “leaking roof” concept. Lancet 1988;2:1467–9.

    Article  PubMed  Google Scholar 

  42. Lane MR, Lee SP. Recurrence of duodenal ulcer after medical treatment. Lancet 1988;1:1147–9.

    Article  PubMed  Google Scholar 

  43. Brogden RN, Pinder RM, Sawyer PR, Speight TM, Avery GS. Tri-potassium di-citrato bismuthate: a report of its pharmacological properties and therapeutic efficacy in peptic ulcer. Drugs 1976;12:401–11.

    PubMed  Google Scholar 

  44. Coghlan JG, Humphreys H, Dooley C, et al.Campylobacter pylori and recurrence of duodenal ulcer a 12-month follow-up study. Lancet 1987;1:1109–11.

    Article  Google Scholar 

  45. Marshall BJ, Warren JR, Blincow ED, et al. Prospective double blind trial of duodenal ulcer relapse after eradication ofCampylobacter pylori. Lancet 1988;2:1437–42.

    Article  PubMed  Google Scholar 

  46. Zheng ZT, Wong ZY, Chu YX, et al. Double-blind short-term trial of furazolidone in peptic ulcer. Lancet 1985;1:1048–9.

    Google Scholar 

  47. Hui WM, Lam SK, Chau PY, et al. Persistence ofCampylobacter pyloridis despite healing of duodenal ulcer and improvement of accompanying duodenitis and gastritis. Dig Dis Sci 1987;32:1255–60.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Loffeld, R.J.L.F. Helicobacter pylori in gastroduodenal disease. Pharmaceutisch Weekblad Scientific Edition 12, 46–50 (1990). https://doi.org/10.1007/BF01970145

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01970145

Keywords

Navigation