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Determination of the stability of tetracycline suspensions by high performance liquid chromatography

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Abstract

High performance liquid chromatography was used to examine the stability of tetracycline suspensions, prepared according to the Formulary of the Dutch Pharmacists and the National Formulary v (Belgium). The influence of the nature of the buffer salt, of the pH, and of the temperature and time of storage are discussed. At slightly acid pH (4 to 5.5) and at room temperature suspensions are stable for at least three months.

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Authors and Affiliations

  1. Institute for Pharmaceutical Sciences, Laboratory for Pharmaceutical Chemistry, Catholic University of Leuven, Van Evenstraat 4, 3000, Leuven, Belgium

    A. Grobben-Verpoorten, Kabala Dihuidi, E. Roets, J. Hoogmartens & H. Vanderhaeghe

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  1. A. Grobben-Verpoorten
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  2. Kabala Dihuidi
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  3. E. Roets
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  4. J. Hoogmartens
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  5. H. Vanderhaeghe
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Grobben-Verpoorten, A., Dihuidi, K., Roets, E. et al. Determination of the stability of tetracycline suspensions by high performance liquid chromatography. Pharmaceutisch Weekblad Scientific Edition 7, 104–108 (1985). https://doi.org/10.1007/BF01968711

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  • DOI: https://doi.org/10.1007/BF01968711

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