Abstract
Because of the relatively poor intestinal absorption of ampicillin sodium, efforts have been made to enhance ampicillin absorption by co-administration of absorption promoters. In the present study the enhancing effect of sodium decanoate on rate and extent of rectal ampicillin absorption in rats has been evaluated after rate-controlled and site-controlled delivery of aqueous solutions. Rectal absorption without enhancer was extremely low (8±7%), and the addition of 0.032M sodium decanoate gave comparable values. However, administration in 0.16M decanoate considerably increased ampicillin bioavailability, to 79±30%, whereas the absorption rate was not significantly affected.
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Van Hoogdalem, E.J., De Boer, A.G. & Breimer, D.D. Rectal absorption enhancement of rate-controlled delivered ampicillin sodium by sodium decanoate in conscious rats. Pharmaceutisch Weekblad Scientific Edition 10, 76–79 (1988). https://doi.org/10.1007/BF01962682
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DOI: https://doi.org/10.1007/BF01962682